Methotrexate and Plaquenil drug interactions - from FDA reports


Drug interactions are reported among people who take Methotrexate and Plaquenil together. This study is created by eHealthMe based on reports of 17,735 people who take Methotrexate and Plaquenil from FDA, and is updated regularly.

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On Dec, 26, 2018

17,735 people who take Methotrexate, Plaquenil are studied.


Number of reports submitted per year:

Methotrexate and Plaquenil drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Fatigue (feeling of tiredness)
  2. Arthralgia (joint pain)
  3. Joint swelling
  4. Nausea (feeling of having an urge to vomit)
  5. Drug ineffective
  6. Headache (pain in head)
  7. Treatment failure
  8. Pain
  9. Drug intolerance (drug sensitivity)
  10. Sleep disorder
1 - 6 months:
  1. Drug ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Abdominal discomfort
  4. Fatigue (feeling of tiredness)
  5. Drug intolerance (drug sensitivity)
  6. Headache (pain in head)
  7. Pain
  8. Vomiting
  9. Alopecia (absence of hair from areas of the body)
  10. Rash
6 - 12 months:
  1. Drug ineffective
  2. Fatigue (feeling of tiredness)
  3. Arthralgia (joint pain)
  4. Nausea (feeling of having an urge to vomit)
  5. Drug intolerance (drug sensitivity)
  6. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  7. Peripheral swelling
  8. Joint swelling
  9. Pain in extremity
  10. Pain
1 - 2 years:
  1. Drug ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Joint swelling
  4. Drug intolerance (drug sensitivity)
  5. Drug effect decreased
  6. Pain
  7. Peripheral swelling
  8. Treatment failure
  9. Arthralgia (joint pain)
  10. Dyspnoea (difficult or laboured respiration)
2 - 5 years:
  1. Drug ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Pain
  4. Treatment failure
  5. Drug intolerance (drug sensitivity)
  6. Fatigue (feeling of tiredness)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Arthralgia (joint pain)
  9. Joint swelling
  10. Migraine (headache)
5 - 10 years:
  1. Drug intolerance (drug sensitivity)
  2. Pain in extremity
  3. Peripheral swelling
  4. Headache (pain in head)
  5. Drug hypersensitivity
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Bone erosion
  8. Pain
  9. Asthenia (weakness)
  10. Hepatotoxicity (chemical-driven liver damage)
not specified:
  1. Drug ineffective
  2. Pain
  3. Arthralgia (joint pain)
  4. Nausea (feeling of having an urge to vomit)
  5. Joint swelling
  6. Fatigue (feeling of tiredness)
  7. Drug intolerance (drug sensitivity)
  8. Headache (pain in head)
  9. Pain in extremity
  10. Treatment failure

Most common drug interactions by gender *:

male:
  1. Drug ineffective
  2. Joint swelling
  3. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  4. Treatment failure
  5. Pulmonary embolism (blockage of the main artery of the lung)
  6. Pneumonia
  7. Drug effect decreased
  8. Diarrhoea
  9. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  10. Dyspnoea (difficult or laboured respiration)

Most common drug interactions by age *:

0-1:
  1. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  2. Pyrexia (fever)
  3. Congenital pyelocaliectasis (birth defect of upper urinary tract obstruction)
  4. Congenital spinal cord anomaly (abnormal spinal cord by birth)
  5. Viral upper respiratory tract infection
  6. Asthenia (weakness)
  7. Atrial septal defect (an abnormal opening between the left and right atria of the heart)
  8. Bladder diverticulum (pouch like projection in the bladder, by birth or acquired)
  9. Cardiac murmur (an heart sound in valve abnormality)
  10. Cardiac septal defect (heart valve defect by birth)
2-9:
  1. Renal failure acute (rapid kidney dysfunction)
  2. Back pain
  3. Dyspnoea (difficult or laboured respiration)
  4. Hypertension (high blood pressure)
  5. Pruritus (severe itching of the skin)
  6. Renal failure chronic (long lasting kidney dysfunction)
  7. Colonic pseudo-obstruction (severe impairment in the ability of the intestines to push food through)
  8. Constipation
  9. Pneumatosis intestinalis (air or gas in an intestine)
  10. Abdominal distension
10-19:
  1. Drug ineffective
  2. Gait disturbance
  3. Arthropathy
  4. Pain
  5. Crohn's disease (condition that causes inflammation of the gastrointestinal tract)
  6. Drug hypersensitivity
  7. Joint swelling
  8. Nausea (feeling of having an urge to vomit)
  9. Injection site pain
  10. Abdominal discomfort
20-29:
  1. Drug ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Arthralgia (joint pain)
  4. Cough
  5. Pain
  6. Vomiting
  7. Drug intolerance (drug sensitivity)
  8. Headache (pain in head)
  9. Nasopharyngitis (inflammation of the nasopharynx)
  10. Weight increased
30-39:
  1. Drug ineffective
  2. Fatigue (feeling of tiredness)
  3. Headache (pain in head)
  4. Nausea (feeling of having an urge to vomit)
  5. Arthralgia (joint pain)
  6. Pain
  7. Nasopharyngitis (inflammation of the nasopharynx)
  8. Joint swelling
  9. Cough
  10. Drug intolerance (drug sensitivity)
40-49:
  1. Drug ineffective
  2. Pain
  3. Arthralgia (joint pain)
  4. Fatigue (feeling of tiredness)
  5. Joint swelling
  6. Nausea (feeling of having an urge to vomit)
  7. Rash
  8. Pain in extremity
  9. Headache (pain in head)
  10. Abdominal discomfort
50-59:
  1. Drug ineffective
  2. Pain
  3. Arthralgia (joint pain)
  4. Joint swelling
  5. Nausea (feeling of having an urge to vomit)
  6. Drug intolerance (drug sensitivity)
  7. Fatigue (feeling of tiredness)
  8. Pain in extremity
  9. Headache (pain in head)
  10. Diarrhoea
60+:
  1. Pain in extremity
  2. Drug hypersensitivity
  3. Pneumonia
  4. Fall
  5. Headache (pain in head)
  6. Peripheral swelling
  7. Rash
  8. Arthropathy
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Synovitis (inflammation of the synovial membrane)

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



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Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Methotrexate and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Plaquenil and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Methotrexate and Plaquenil
a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

What would happen?

Predict new side effects and undetected conditions when you take Methotrexate and Plaquenil

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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