Morphine and Lyrica drug interactions - from FDA reports


Drug interactions are reported among people who take Morphine and Lyrica together. This study is created by eHealthMe based on reports of 3,920 people who take Morphine and Lyrica from FDA, and is updated regularly.

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On Jan, 04, 2019

3,920 people who take Morphine, Lyrica are studied.


Number of reports submitted per year:

Morphine and Lyrica drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Somnolence (a state of near-sleep, a strong desire for sleep)
  2. Nausea (feeling of having an urge to vomit)
  3. Pyrexia (fever)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Drug ineffective
  6. Pneumonia
  7. Confusional state
  8. Dizziness
  9. Constipation
  10. Insomnia (sleeplessness)
1 - 6 months:
  1. Drug ineffective
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Oedema peripheral (superficial swelling)
  4. Confusional state
  5. Insomnia (sleeplessness)
  6. Nausea (feeling of having an urge to vomit)
  7. Dizziness
  8. Weight increased
  9. Dry mouth
  10. Fatigue (feeling of tiredness)
6 - 12 months:
  1. Sepsis (a severe blood infection that can lead to organ failure and death)
  2. Drug ineffective
  3. Fall
  4. Pneumonia
  5. Pyrexia (fever)
  6. Renal failure acute (rapid kidney dysfunction)
  7. Confusional state
  8. Dyspnoea (difficult or laboured respiration)
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Weight increased
1 - 2 years:
  1. Drug ineffective
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Suicide attempt
  4. Dyspnoea (difficult or laboured respiration)
  5. Gait disturbance
  6. Pneumonia
  7. Respiratory failure (inadequate gas exchange by the respiratory system)
  8. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  9. Chest pain
  10. Depression
2 - 5 years:
  1. Fatigue (feeling of tiredness)
  2. Anaemia (lack of blood)
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Arthralgia (joint pain)
  5. Diarrhoea
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Abdominal pain
  8. Anxiety
  9. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  10. Depression
5 - 10 years:
  1. Hypoacusis (loss of hearing)
  2. Hypoaesthesia (reduced sense of touch or sensation)
  3. Influenza like illness
  4. Intervertebral disc disorder (spinal disc disorder)
  5. Joint instability (a condition in which the joints aren't sufficiently supported)
  6. Joint swelling
  7. Kidney infection
  8. Lethargy (tiredness)
  9. Ligament rupture (tear in ligament)
  10. Lower limb fracture
10+ years:
  1. Adverse drug reaction
  2. Drug effect decreased
  3. Drug ineffective
  4. Gastric disorder (disease of stomach)
  5. Gastric ulcer (stomach ulcer)
  6. Gastric ulcer haemorrhage (bleeding ulcer of stomach)
  7. Hyperhidrosis (abnormally increased sweating)
  8. Hypokinesia (decreased bodily movement)
  9. Limb injury
  10. Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
not specified:
  1. Drug ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Anxiety
  4. Pain in extremity
  5. Fall
  6. Fatigue (feeling of tiredness)
  7. Dizziness
  8. Dyspnoea (difficult or laboured respiration)
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Arthralgia (joint pain)

Most common drug interactions by gender *:

female:
  1. Dyspnoea (difficult or laboured respiration)
  2. Fatigue (feeling of tiredness)
  3. Arthralgia (joint pain)
  4. Pyrexia (fever)
  5. Insomnia (sleeplessness)
  6. Hypoaesthesia (reduced sense of touch or sensation)
  7. Weight decreased
  8. Vomiting
  9. Headache (pain in head)
  10. Malaise (a feeling of general discomfort or uneasiness)
male:
  1. Drug ineffective
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Diarrhoea
  4. Constipation
  5. Depression
  6. Fall
  7. Weight decreased
  8. Oedema peripheral (superficial swelling)
  9. Dyspnoea (difficult or laboured respiration)
  10. Malaise (a feeling of general discomfort or uneasiness)

Most common drug interactions by age *:

0-1:
  1. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  2. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
2-9:
  1. Blood pressure decreased
  2. Eosinophilic myocarditis (acute and fulminate congestive heart failure)
  3. Headache (pain in head)
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Swelling face
  6. Urticaria (rash of round, red welts on the skin that itch intensely)
  7. Vomiting
  8. Alanine aminotransferase increased
  9. Aspartate aminotransferase increased
  10. Atrioventricular block second degree (heart block second degree)
10-19:
  1. Pyrexia (fever)
  2. Hot flush (sudden feelings of heat)
  3. Diarrhoea
  4. Abdominal pain upper
  5. Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
  6. Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
  7. Cytomegalovirus viraemia (cytomegalo virus in blood stream)
  8. Fatigue (feeling of tiredness)
  9. Febrile neutropenia (fever with reduced white blood cells)
  10. Hyperhidrosis (abnormally increased sweating)
20-29:
  1. Nausea (feeling of having an urge to vomit)
  2. Pain in extremity
  3. Dyspnoea (difficult or laboured respiration)
  4. Abdominal pain
  5. Abdominal pain upper
  6. Fatigue (feeling of tiredness)
  7. Oedema peripheral (superficial swelling)
  8. Chest pain
  9. Vomiting
  10. Anxiety
30-39:
  1. Fatigue (feeling of tiredness)
  2. Oedema peripheral (superficial swelling)
  3. Somnolence (a state of near-sleep, a strong desire for sleep)
  4. Weight decreased
  5. Arthralgia (joint pain)
  6. Drug ineffective
  7. Nausea (feeling of having an urge to vomit)
  8. Headache (pain in head)
  9. Fall
  10. Abdominal pain
40-49:
  1. Pyrexia (fever)
  2. Fatigue (feeling of tiredness)
  3. Nausea (feeling of having an urge to vomit)
  4. Pain in extremity
  5. Muscle spasms (muscle contraction)
  6. Drug ineffective
  7. Anxiety
  8. Depression
  9. Fall
  10. Somnolence (a state of near-sleep, a strong desire for sleep)
50-59:
  1. Drug ineffective
  2. Anxiety
  3. Dizziness
  4. Pain in extremity
  5. Hypoaesthesia (reduced sense of touch or sensation)
  6. Arthralgia (joint pain)
  7. Insomnia (sleeplessness)
  8. Dyspnoea (difficult or laboured respiration)
  9. Fall
  10. Pyrexia (fever)
60+:
  1. Dizziness
  2. Insomnia (sleeplessness)
  3. Dyspnoea (difficult or laboured respiration)
  4. Constipation
  5. Headache (pain in head)
  6. Asthenia (weakness)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Confusional state
  9. Oedema peripheral (superficial swelling)
  10. Fatigue (feeling of tiredness)

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



Do you take Morphine and Lyrica?


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Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Morphine and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Lyrica and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Morphine and Lyrica
a b c d e f g h i j k l m n o p q r s t u v w x y z

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What would happen?

Predict new side effects and undetected conditions when you take Morphine and Lyrica

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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