Naprelan and Humira drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Naprelan and Humira. Common interactions include drug ineffective among females and dyspnoea among males.
The phase IV clinical study analyzes what interactions people who take Naprelan and Humira have. It is created by eHealthMe based on reports of 23 people who take Naprelan and Humira from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
23 people who take Naprelan and Humira together, and have interactions are studied.
What is Naprelan?
Naprelan has active ingredients of naproxen sodium. eHealthMe is studying from 716 Naprelan users for its effectiveness, alternative drugs and more.
What is Humira?
Humira has active ingredients of adalimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 650,636 Humira users for its effectiveness, alternative drugs and more.
Number of Naprelan and Humira reports submitted per year:

Common Naprelan and Humira drug interactions by gender *:
female:
- Drug ineffective
- Drug intolerance
- Memory impairment
- Injection site erythema
- Injection site pain
- Injection site pruritus
- Injection site reaction
- Injection site swelling
- Injection site urticaria
- Drug hypersensitivity
male:
- Dyspnoea
- Blood pressure increased
- Dizziness
- Fatigue
- Lymphoma
- Pleural effusion
- Weight increased
- Chest pain
- Coronary artery disease
- Drug ineffective
Common Naprelan and Humira drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Arthritis
- Hepatic enzyme increased
- Influenza
- Sinusitis
- Abdominal pain lower
- Amenorrhoea
- Arthralgia
- Back pain
- Breast tenderness
- Constipation
40-49:
- Drug ineffective
- Nasopharyngitis
50-59:
- Drug ineffective
- Drug intolerance
- Memory impairment
- Injection site erythema
- Injection site pain
- Injection site pruritus
- Injection site reaction
- Injection site swelling
- Injection site urticaria
- Drug hypersensitivity
60+:
- Dyspnoea
- Ascites
- Weight increased
- Asthenia
- Atrioventricular block
- Dizziness
- Fatigue
- Irritable bowel syndrome
- Lymphoma
- Pleural effusion
Common conditions people have *:
- Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 21.74%
- Pain: 4 people, 17.39%
- Psoriasis (immune-mediated disease that affects the skin): 3 people, 13.04%
- Joint Pain: 2 people, 8.70%
- Insomnia (sleeplessness): 2 people, 8.70%
- Injection Site Urticaria (rash of round, red welts on the skin at injection site): 2 people, 8.70%
- Inflammation: 2 people, 8.70%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.70%
- High Blood Pressure: 2 people, 8.70%
- High Blood Cholesterol: 2 people, 8.70%
* Approximation only. Some reports may have incomplete information.
Do you take Naprelan and Humira?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Chiriac A, Brzezinski P, Stolnicu S, Podoleanu C, Moldovan C, Molnar C, Taranu T, "Eosinophilia–A rare possible adverse reaction during anti-tumor necrosis factor-alpha therapy for psoriasis", Journal of Dermatological Treatment, 2016 Mar .
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
Browse all drug interactions of Naprelan and Humira:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Humira side effects:
- Drug ineffective: 93,489 reports
- Joint pain: 47,464 reports
- Pain: 47,288 reports
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 39,149 reports
- Fatigue (feeling of tiredness): 38,407 reports
- Rashes (redness): 32,791 reports
- Diarrhea: 27,396 reports
Browse all side effects of Humira:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Humira interactions:
- Humira and Methotrexate: 129,969 reports
- Humira and Prednisone: 69,333 reports
- Humira and Enbrel: 65,630 reports
- Humira and Orencia: 38,273 reports
- Humira and Remicade: 35,200 reports
- Humira and Sulfasalazine: 34,633 reports
- Humira and Actemra: 32,696 reports
- Humira and Leflunomide: 29,914 reports
- Humira and Arava: 29,038 reports
- Humira and Xeljanz: 28,451 reports
Browse all interactions between Humira and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on naproxen sodium and adalimumab (the active ingredients of Naprelan and Humira, respectively), and Naprelan and Humira (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Naprelan and Humira.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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