Naprosyn and Indocin drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among 74 people who take Naprosyn and Indocin. Common interactions include abdominal pain upper among females, and acute myocardial infarction among males.

The phase IV clinical study analyzes what interactions people who take Naprosyn and Indocin have. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

On Sep, 25, 2023

74 people who take Naprosyn and Indocin together, and have interactions are studied.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is used in pain. Currently, eHealthMe is studying from 16,478 Naprosyn users.

What is Indocin?

Indocin has active ingredients of indomethacin. It is used in gout. Currently, eHealthMe is studying from 4,535 Indocin users.

Number of Naprosyn and Indocin reports submitted per year:

Naprosyn and Indocin drug interactions.

Common Naprosyn and Indocin drug interactions by gender *:


  1. Abdominal pain upper
  2. Chronic kidney disease
  3. Contusion
  4. Fall
  5. Fatigue
  6. Hyponatraemia
  7. Injury
  8. Metrorrhagia
  9. Nausea
  10. Rhinitis allergic


  1. Acute myocardial infarction
  2. Intervertebral disc degeneration
  3. Anxiety
  4. Coronary artery bypass
  5. Gastric ulcer
  6. Gastrooesophageal reflux disease
  7. Hypercholesterolaemia
  8. Hypotension
  9. Injury
  10. Memory impairment

Common Naprosyn and Indocin drug interactions by age *:


  1. Amnesia




  1. Arthralgia
  2. Insomnia
  3. Acne
  4. Allergen nos skin test positive
  5. Antinuclear factor positive
  6. Blood immunoglobulin e increased
  7. Bronchitis
  8. Bronchospasm
  9. Cardiomegaly
  10. Chest pain


  1. Urinary tract infection
  2. Abdominal pain upper
  3. Fall
  4. Rhinitis allergic
  5. Contusion
  6. Cyst
  7. Drug dependence
  8. Dysmenorrhoea
  9. Dyspepsia
  10. Flatulence


  1. Chronic kidney disease
  2. Renal failure
  3. Dizziness
  4. Nephropathy


  1. Anaemia
  2. Renal disorder
  3. Acute myocardial infarction
  4. Angina unstable
  5. Arteriosclerosis coronary artery
  6. Bone disorder
  7. Coronary artery disease
  8. Depression
  9. Drug hypersensitivity
  10. Essential hypertension


  1. Gait disturbance
  2. Glycosylated haemoglobin increased
  3. Gouty arthritis
  4. Hypercalcaemia
  5. Hypercholesterolaemia
  6. Hypertension
  7. Hyperthyroidism
  8. Hypoaesthesia
  9. Memory impairment
  10. Multiple injuries


  1. Acute myocardial infarction
  2. Anhedonia
  3. Injury
  4. Memory impairment
  5. Nausea
  6. Nephrolithiasis
  7. Peptic ulcer
  8. Rotator cuff syndrome
  9. Tooth fracture
  10. Abdominal pain lower

Common conditions people have *:

  1. High Blood Cholesterol: 5 people, 6.76%
  2. Back Pain: 5 people, 6.76%
  3. Osteoporosis (bones weak and more likely to break): 4 people, 5.41%
  4. High Blood Pressure: 4 people, 5.41%
  5. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Naprosyn and Indocin?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Common Naprosyn side effects:

Browse all side effects of Naprosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Indocin side effects:

Browse all side effects of Indocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Naprosyn interactions:

Browse all interactions between Naprosyn and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Indocin interactions:

Browse all interactions between Indocin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on naproxen and indomethacin (the active ingredients of Naprosyn and Indocin, respectively), and Naprosyn and Indocin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Naprosyn and Indocin.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: