Paracetamol and Mercaptopurine drug interactions - from FDA reports
Drug interactions are reported among people who take Paracetamol and Mercaptopurine together. This study is created by eHealthMe based on reports of 179 people who take Paracetamol and Mercaptopurine from FDA, and is updated regularly.
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179 people who take Paracetamol, Mercaptopurine are studied.
Number of reports submitted per year:

Most common drug interactions over time *:
< 1 month:
- Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)
- Skin toxicity (skin damage due to toxin/poison)
- Staphylococcal infection (an infection with staphylococcus bacteria)
- Thrombocytopenia (decrease of platelets in blood)
- Vomiting
- Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
- Anal fistula
- C-reactive protein increased
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
1 - 6 months:
- Bone marrow failure
- Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
- Cellulitis (infection under the skin)
- Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
- Blood albumin decreased
- C-reactive protein increased
- Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
- Escherichia test positive
- Haematocrit decreased
6 - 12 months:
n/a
1 - 2 years:
- Acute hepatic failure
- Drug level increased
- Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
- Hepatotoxicity (chemical-driven liver damage)
- Sinusitis (inflammation of sinus)
2 - 5 years:
- Abnormal behaviour
- Aphasia (damage to the parts of the brain that control language)
- Hemianopia homonymous (visual field defect involving either the two right or the two left halves of the visual fields of both eyes)
- Hemisensory neglect (loss of sensation on one side of the body-neglect)
- Herpes zoster
- Motor dysfunction (dysfunction of a muscle, nerve, or centre that effects or produces motion)
- Muscular weakness (muscle weakness)
- Optic atrophy (the loss of a proportion of optic disc nerve fibres)
- Osmotic demyelination syndrome (increased serum sodium level leads to hyponatremic encephalopathy)
- Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
5 - 10 years:
n/a
10+ years:
n/a
not specified:
- Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
- Febrile neutropenia (fever with reduced white blood cells)
- Hyperbilirubinaemia (excess of bilirubin in the blood)
- Cellulitis (infection under the skin)
- Drug hypersensitivity
- Bone marrow failure
- Gamma-glutamyltransferase increased
- Hepatic enzyme increased
- Hypertriglyceridaemia (excess of triglycerides in the blood)
Most common drug interactions by gender *:
female:
- Dystonia (abnormal muscle tone)
- Fatigue (feeling of tiredness)
- Hypocalcaemia (levels of calcium in blood serum are abnormally low)
- Lip swelling
- Nausea (feeling of having an urge to vomit)
- Swollen tongue (swelling of tongue)
- Anal fistula
- Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
- Blood immunoglobulin a decreased
- Blood immunoglobulin g decreased
male:
- Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
- Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)
- Influenza like illness
- Lethargy (tiredness)
- Leukopenia (less number of white blood cells in blood)
- Pelvic pain
- Platelet count decreased
- Rectal abscess (pus in rectum)
- Rectal discharge (discharge from rectum)
Most common drug interactions by age *:
0-1:
- Hepatocellular injury (liver injury)
- Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
2-9:
- Gastroenteritis (inflammation of stomach and intestine)
- Hypophagia (reduced food intake)
- Hypotension (abnormally low blood pressure)
- Injection site pain
- Irritability
- Mucosal inflammation (infection of mucous membrane)
- Urticaria (rash of round, red welts on the skin that itch intensely)
- Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
- Cellulitis (infection under the skin)
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
10-19:
- Febrile neutropenia (fever with reduced white blood cells)
- Fatigue (feeling of tiredness)
- Febrile bone marrow aplasia (bone marrow greatly decreases or stops production of blood cells)
- Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
- Dehydration (dryness resulting from the removal of water)
- Drug ineffective
- Dystonia (abnormal muscle tone)
- Lacrimation increased
- Lip swelling
- Swollen tongue (swelling of tongue)
20-29:
- Febrile neutropenia (fever with reduced white blood cells)
- Anal fistula
- Erythema (redness of the skin)
- Hyperhidrosis (abnormally increased sweating)
- Hypertension (high blood pressure)
- Infusion related reaction
- Palpitations (feelings or sensations that your heart is pounding or racing)
- Swelling face
- Abdominal pain
- Anorectal infection
30-39:
- Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
- Anal fistula
- C-reactive protein increased
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
- Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)
- Influenza like illness
- Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
- Lethargy (tiredness)
- Leukopenia (less number of white blood cells in blood)
- Neutropenia (an abnormally low number of neutrophils)
50-59:
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Chills (felling of cold)
- Disorientation (disability in which the senses of time, direction, and recognition of people and places)
- Dizziness
- Dysarthria (speech disorder)
- Facial paresis (weakness in facial muscle movement)
- Fall
- Femoral neck fracture (neck of femur bone fracture)
- General physical health deterioration (weak health status)
- Hemianopia homonymous (visual field defect involving either the two right or the two left halves of the visual fields of both eyes)
60+:
- Hypocalcaemia (levels of calcium in blood serum are abnormally low)
- Hypokalaemia (low potassium)
- Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
- Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
* Approximation only. Some reports may have incomplete information.
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Related studies
Paracetamol
Paracetamol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Paracetamol 58,825 users)
Mercaptopurine
Mercaptopurine has active ingredients of mercaptopurine. It is often used in crohn's disease. (latest outcomes from Mercaptopurine 12,929 users)
Browse by gender and age
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Interactions between Paracetamol and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y zInteractions between Mercaptopurine and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all drug interactions of Paracetamol and Mercaptopurine
a b c d e f g h i j k l m n o p q r s t u v w x y zWhat would happen?
Predict new side effects and undetected conditions when you take Paracetamol and Mercaptopurine (29,063 reports studied)
FDA reports used in this study
- Want to find out more about the FDA reports used in the study? You can request them from FDA.
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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.
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