Paxil and Zide drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Paxil and Zide. Common interactions include dyspnoea among females and dizziness among males.
The phase IV clinical study analyzes what interactions people who take Paxil and Zide have. It is created by eHealthMe based on reports of 1,918 people who take Paxil and Zide from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
1,918 people who take Paxil and Zide together, and have interactions are studied.
What is Paxil?
Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 91,161 Paxil users for its effectiveness, alternative drugs and more.
What is Zide?
Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 161,955 Zide users for its effectiveness, alternative drugs and more.
Number of Paxil and Zide reports submitted per year:

Paxil and Zide drug interactions by gender *:
Paxil and Zide drug interactions by age *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Paxil and Zide?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
Common Paxil and Zide interactions:
- Weakness: 197 reports
- Pain: 190 reports
- Breathing difficulty: 169 reports
- Joint pain: 151 reports
- Cough: 109 reports
- Oedema peripheral (superficial swelling): 80 reports
- Osteoarthritis (a joint disease caused by cartilage loss in a joint): 59 reports
Browse all drug interactions of Paxil and Zide:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Paxil side effects:
- Stress and anxiety: 7,508 reports
- Dizziness: 6,673 reports
- Fatigue (feeling of tiredness): 6,664 reports
- Depression: 5,936 reports
- Headache (pain in head): 5,796 reports
Browse all side effects of Paxil:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Zide side effects:
- Fatigue (feeling of tiredness): 11,812 reports
- High blood pressure: 10,348 reports
- Drug ineffective: 10,153 reports
- Pain: 9,179 reports
- Diarrhea: 9,036 reports
- Dizziness: 8,717 reports
- Weakness: 8,692 reports
Browse all side effects of Zide:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Paxil interactions:
- Paxil and Xanax: 5,066 reports
- Paxil and Aspirin: 4,628 reports
- Paxil and Synthroid: 4,003 reports
- Paxil and Wellbutrin: 3,944 reports
- Paxil and Lipitor: 3,901 reports
- Paxil and Seroquel: 3,706 reports
- Paxil and Ambien: 3,295 reports
- Paxil and Prilosec: 3,271 reports
- Paxil and Lasix: 3,270 reports
- Paxil and Prednisone: 3,262 reports
Browse all interactions between Paxil and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Zide interactions:
- Zide and Lisinopril: 25,892 reports
- Zide and Aspirin: 25,735 reports
- Zide and Amlodipine: 19,118 reports
- Zide and Metformin: 19,069 reports
- Zide and Prednisone: 14,942 reports
- Zide and Omeprazole: 14,803 reports
- Zide and Losartan: 12,955 reports
- Zide and Simvastatin: 12,954 reports
- Zide and Atenolol: 12,951 reports
- Zide and Gabapentin: 10,772 reports
Browse all interactions between Zide and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on paroxetine hydrochloride and hydrochlorothiazide (the active ingredients of Paxil and Zide, respectively), and Paxil and Zide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Paxil and Zide.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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