Phenytoin sodium and Plavix drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Phenytoin sodium and Plavix together. This study is created by eHealthMe based on reports of 86 people who take Phenytoin sodium and Plavix from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on phenytoin sodium and clopidogrel bisulfate (the active ingredients of Phenytoin sodium and Plavix, respectively), and Phenytoin sodium and Plavix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Phenytoin sodium?

Phenytoin sodium has active ingredients of phenytoin sodium. It is often used in epilepsy. (latest outcomes from Phenytoin sodium 4,659 users)

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in blood clots. (latest outcomes from Plavix 121,658 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Mar, 15, 2019

86 people who take Phenytoin sodium, Plavix are studied.


Number of reports submitted per year:

Phenytoin sodium and Plavix drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Cerebral haemorrhage (bleeding within the brain)
  2. Death
  3. Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
  4. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  5. Altered state of consciousness (altered state of mind)
  6. Appetite disorder (abnormal eating habits)
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  8. Asthenia (weakness)
  9. Back disorder
  10. Back pain
1 - 6 months:
  1. Cerebral haemorrhage (bleeding within the brain)
  2. Epistaxis (bleed from the nose)
  3. Mouth haemorrhage (bleeding from mouth)
  4. Blindness transient (sudden loss of vision)
  5. Disseminated intravascular coagulation (systemic activation of blood coagulation)
  6. Hemiplegia (paralysis of one side of the body)
  7. International normalised ratio increased
  8. Mediastinitis (inflammation of the tissues in the mid-chest)
  9. Postoperative infection
  10. Renal failure (kidney dysfunction)
6 - 12 months:
  1. Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
  2. Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
  3. Tongue haemorrhage (bleeding from tongue)
  4. Anaemia (lack of blood)
  5. Multiple injuries
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Asthenia (weakness)
  9. Bone density decreased
  10. Emotional distress
1 - 2 years:
  1. Subdural haemorrhage (bleeding between the skull and the surface of the brain)
  2. Swollen tongue (swelling of tongue)
2 - 5 years:
  1. Coma (state of unconsciousness lasting more than six hours)
  2. Intracranial haematoma (intracranial localized swelling filled with blood)
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
5 - 10 years:
  1. Cerebral haemorrhage (bleeding within the brain)
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Platelet count decreased
  4. Thrombocythaemia (an increased number of platelets in the circulating blood)
10+ years:

n/a

not specified:
  1. Asthenia (weakness)
  2. Urine abnormality
  3. Balance disorder
  4. Cardiac failure congestive
  5. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  6. Arthralgia (joint pain)
  7. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  8. Pain
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

Most common drug interactions by gender *:

female:
  1. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Injury
  4. Syncope (loss of consciousness with an inability to maintain postural tone)
  5. Gait disturbance
  6. Bradycardia (abnormally slow heart action)
  7. Cardiac arrest
  8. Dyspnoea (difficult or laboured respiration)
  9. Hypotension (abnormally low blood pressure)
  10. Pneumonia
male:
  1. Cerebral haemorrhage (bleeding within the brain)
  2. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. Mouth haemorrhage (bleeding from mouth)
  5. Pain
  6. Arthralgia (joint pain)
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  8. Calcium deficiency (lack of calcium)
  9. Osteoporosis (bones weak and more likely to break)
  10. Acetabulum fracture (socket of the hip joint- fracture)

Most common drug interactions by age *:

0-1:
  1. Balance disorder
  2. Bradycardia (abnormally slow heart action)
  3. Cholecystitis chronic (long lasting infection of gallbladder)
  4. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  5. Diabetic complication
  6. Dyspnoea (difficult or laboured respiration)
  7. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  8. Hypotension (abnormally low blood pressure)
  9. Nervous system disorder (a general class of medical conditions affecting the nervous system)
  10. Orthopnoea (shortness of breath (dyspnea) when lying down)
2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:
  1. Coma (state of unconsciousness lasting more than six hours)
  2. Intracranial haematoma (intracranial localized swelling filled with blood)
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
40-49:
  1. Epistaxis (bleed from the nose)
  2. Blindness transient (sudden loss of vision)
  3. Cerebral haemorrhage (bleeding within the brain)
  4. Hemiplegia (paralysis of one side of the body)
  5. International normalised ratio increased
  6. Mouth haemorrhage (bleeding from mouth)
  7. Dyspnoea (difficult or laboured respiration)
  8. Memory impairment
  9. Postoperative infection
  10. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
50-59:
  1. Mediastinitis (inflammation of the tissues in the mid-chest)
  2. Multiple injuries
  3. Sepsis (a severe blood infection that can lead to organ failure and death)
  4. Thrombocytopenia (decrease of platelets in blood)
  5. Wound haemorrhage (bleeding wound)
  6. Bacteraemia (presence of bacteria in the blood)
  7. Blood pressure increased
  8. Cardiac arrest
  9. Cardiac failure
  10. Chest pain
60+:
  1. Asthenia (weakness)
  2. Urine abnormality
  3. Emotional distress
  4. Injury
  5. Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
  6. Pain
  7. Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
  8. Syncope (loss of consciousness with an inability to maintain postural tone)
  9. Tongue haemorrhage (bleeding from tongue)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

* Approximation only. Some reports may have incomplete information.


Do you take Phenytoin sodium and Plavix?

You are not alone:




Related publications that referenced our studies


Results from eHealthMe (non-FDA) reports of taking Phenytoin sodium and Plavix together

Drug effectiveness (drug is found to be effective) over time *:
Phenytoin sodium:
  • < 1 month: 0.0% (0 of 0 people)
  • 1 - 6 months: 0.0% (0 of 0 people)
  • 6 - 12 months: 0.0% (0 of 1 people)
  • 1 - 2 years: 0.0% (0 of 0 people)
  • 2 - 5 years: 0.0% (0 of 0 people)
  • 5 - 10 years: 0.0% (0 of 0 people)
  • 10+ years: 0.0% (0 of 0 people)
  • not specified: 0.0% (0 of 0 people)
Plavix:
  • < 1 month: 0.0% (0 of 0 people)
  • 1 - 6 months: 0.0% (0 of 0 people)
  • 6 - 12 months: 0.0% (0 of 0 people)
  • 1 - 2 years: 100% (1 of 1 people)
  • 2 - 5 years: 0.0% (0 of 0 people)
  • 5 - 10 years: 0.0% (0 of 0 people)
  • 10+ years: 0.0% (0 of 0 people)
  • not specified: 0.0% (0 of 0 people)
Drug effectiveness (drug is found to be effective) by gender *:
Phenytoin sodium:
  • female: 0.0% (0 of 0 people)
  • male: 0.0% (0 of 1 people)
Plavix:
  • female: 0.0% (0 of 0 people)
  • male: 100% (1 of 1 people)
Drug effectiveness (drug is found to be effective) by age *:
Phenytoin sodium:
  • 0-1: 0.0% (0 of 0 people)
  • 2-9: 0.0% (0 of 0 people)
  • 10-19: 0.0% (0 of 0 people)
  • 20-29: 0.0% (0 of 0 people)
  • 30-39: 0.0% (0 of 0 people)
  • 40-49: 0.0% (0 of 0 people)
  • 50-59: 0.0% (0 of 0 people)
  • 60+: 0.0% (0 of 1 people)
Plavix:
  • 0-1: 0.0% (0 of 0 people)
  • 2-9: 0.0% (0 of 0 people)
  • 10-19: 0.0% (0 of 0 people)
  • 20-29: 0.0% (0 of 0 people)
  • 30-39: 0.0% (0 of 0 people)
  • 40-49: 0.0% (0 of 0 people)
  • 50-59: 0.0% (0 of 0 people)
  • 60+: 100.0% (1 of 1 people)
Race of the people *:
  • African American, Non-Hispanic: 0.0 %
  • American Indian/Alaska Native: 0.0 %
  • Asian: 12.5 %
  • Hispanic: 0.0 %
  • Native Hawaiians/Pacific Islanders: 0.0 %
  • Two or more races: 0.0 %
  • White, Non-Hispanic: 87.5 %

* Approximation only.


Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Phenytoin sodium and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Plavix and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Phenytoin sodium and Plavix
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Phenytoin sodium and Plavix



FDA reports used in this study


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