Phenytoin and Dilaudid drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among people who take Phenytoin and Dilaudid. Common interactions include convulsion among females and mucosal inflammation among males.

The phase IV clinical study analyzes what interactions people who take Phenytoin and Dilaudid have. It is created by eHealthMe based on reports of 41 people who take Phenytoin and Dilaudid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

41 people who take Phenytoin and Dilaudid together, and have interactions are studied.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 13,397 Phenytoin users for its effectiveness, alternative drugs and more.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 87,684 Dilaudid users for its effectiveness, alternative drugs and more.

Number of Phenytoin and Dilaudid reports submitted per year:

Phenytoin and Dilaudid drug interactions.

Common Phenytoin and Dilaudid drug interactions by gender *:


  1. Convulsion
  2. Anaemia
  3. Hypertension
  4. Asthenia
  5. Back pain
  6. Pain in extremity
  7. Vomiting
  8. Contusion
  9. Lumbar spinal stenosis
  10. Nausea


  1. Mucosal inflammation
  2. Sepsis
  3. Convulsion
  4. Cystitis haemorrhagic
  5. Cytomegalovirus infection
  6. Device related infection
  7. Dyspnoea
  8. Hyperbilirubinaemia
  9. Hyponatraemia
  10. Impaired gastric emptying

Common Phenytoin and Dilaudid drug interactions by age *:






  1. Superior sagittal sinus thrombosis
  2. Convulsion
  3. Haemorrhagic stroke
  4. Intracranial venous sinus thrombosis
  5. Thalamic infarction




  1. Drug ineffective
  2. Femoral neck fracture
  3. Hallucination
  4. Hip fracture
  5. Hyperparathyroidism
  6. Lymphoedema
  7. Osteoporosis
  8. Thyroid neoplasm


  1. Sepsis
  2. Mucosal inflammation
  3. Deep vein thrombosis
  4. Dehydration
  5. Hypotension
  6. Renal failure chronic
  7. Bk virus infection
  8. Cystitis haemorrhagic
  9. Cytomegalovirus infection
  10. Hyperbilirubinaemia


  1. Osteomyelitis
  2. Pain in extremity
  3. Vomiting
  4. Allodynia
  5. Arthritis bacterial
  6. Asthenia
  7. Blood albumin decreased
  8. Blood calcium decreased
  9. Blood glucose increased
  10. Blood magnesium decreased


  1. Headache
  2. Convulsion
  3. Pain in extremity
  4. Rib fracture
  5. Vomiting
  6. Abdominal pain
  7. Actinomycosis
  8. Activated partial thromboplastin time prolonged
  9. Angina pectoris
  10. Aortic stenosis

Common conditions people have *:

  1. Headache (pain in head): 9 people, 21.95%
  2. Nausea (feeling of having an urge to vomit): 8 people, 19.51%
  3. Multiple Myeloma (cancer of the plasma cells): 8 people, 19.51%
  4. Depression: 8 people, 19.51%
  5. Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 8 people, 19.51%
  6. High Blood Pressure: 7 people, 17.07%
  7. Diarrhea: 7 people, 17.07%
  8. Febrile Neutropenia (fever with reduced white blood cells): 6 people, 14.63%
  9. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 6 people, 14.63%
  10. Allergies: 6 people, 14.63%

* Approximation only. Some reports may have incomplete information.

Do you take Phenytoin and Dilaudid?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

  • Wandalkar P, Daswani BR, Pandit PT, Ghongane BB, "A case of Phenytoin toxicity", INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY, 2014 Jan .

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Common Phenytoin and Dilaudid interactions:

Browse all drug interactions of Phenytoin and Dilaudid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Phenytoin interactions:

Browse all interactions between Phenytoin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Dilaudid interactions:

Browse all interactions between Dilaudid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on phenytoin and hydromorphone hydrochloride (the active ingredients of Phenytoin and Dilaudid, respectively), and Phenytoin and Dilaudid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Phenytoin and Dilaudid.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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