Pitocin and Benadryl drug interactions - a phase IV clinical study of FDA data


Drug interactions are reported among 17 people who take Pitocin and Benadryl. Common interactions include headache among females.

The phase IV clinical study analyzes what interactions people who take Pitocin and Benadryl have. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

What are phase IV trials?

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

17 people who take Pitocin and Benadryl together, and have interactions are studied.

What is Pitocin?

Pitocin has active ingredients of oxytocin. It is used in labor induction. Currently, eHealthMe is studying from 714 Pitocin users.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is used in allergies. Currently, eHealthMe is studying from 99,368 Benadryl users.

Number of Pitocin and Benadryl reports submitted per year:

Pitocin and Benadryl drug interactions.

Common Pitocin and Benadryl drug interactions by gender *:


  1. Headache
  2. Maternal exposure during pregnancy
  3. Abdominal pain upper
  4. Aggression
  5. Back pain
  6. Blood cholesterol increased
  7. Blood pressure increased
  8. Bradyarrhythmia
  9. Cardio-respiratory arrest
  10. Cardiomegaly



Common Pitocin and Benadryl drug interactions by age *:


  1. Foetal exposure during pregnancy
  2. Premature baby
  3. Apparent life threatening event
  4. Bradycardia
  5. Cardiac murmur
  6. Craniosynostosis
  7. Gastrooesophageal reflux disease
  8. Hypothermia
  9. Joint range of motion decreased






  1. Atelectasis
  2. Atrial fibrillation
  3. Blindness
  4. Blindness unilateral
  5. Blood calcium decreased
  6. Blood carbon dioxide decreased
  7. Blood fibrinogen decreased
  8. Blood glucose increased
  9. Blood potassium increased
  10. Blood pressure decreased


  1. Maternal exposure during pregnancy
  2. Pre-eclampsia
  3. Blighted ovum
  4. Drug ineffective
  5. Foetal exposure during pregnancy
  6. Haematochezia
  7. Hypotension
  8. Maternal exposure during delivery
  9. Nausea
  10. Post lumbar puncture syndrome







Common conditions people have *:

  1. Nausea (feeling of having an urge to vomit): 5 people, 29.41%
  2. Asthma: 4 people, 23.53%
  3. Pain: 4 people, 23.53%
  4. Birth Control: 3 people, 17.65%
  5. Type 1 Diabetes: 3 people, 17.65%
  6. Urinary Tract Infection: 2 people, 11.76%
  7. Stress And Anxiety: 2 people, 11.76%
  8. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 11.76%
  9. Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 11.76%
  10. Procedural Pain: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Pitocin and Benadryl?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Common Benadryl side effects:

Browse all side effects of Benadryl:

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Common Benadryl interactions:

Browse all interactions between Benadryl and drugs from A to Z:

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How the study uses the data?

The study uses data from the FDA. It is based on oxytocin and diphenhydramine hydrochloride (the active ingredients of Pitocin and Benadryl, respectively), and Pitocin and Benadryl (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Pitocin and Benadryl.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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