Premarin and Paraflex drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among 2 people who take Premarin and Paraflex. Common interactions include anaphylactic reaction among females.
The phase IV clinical study analyzes what interactions people who take Premarin and Paraflex have. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
2 people who take Premarin and Paraflex together, and have interactions are studied.
What is Premarin?
Premarin has active ingredients of estrogens, conjugated. It is used in hormone replacement therapy. Currently, eHealthMe is studying from 97,936 Premarin users.
What is Paraflex?
Paraflex has active ingredients of chlorzoxazone. Currently, eHealthMe is studying from 229 Paraflex users.
Number of Premarin and Paraflex reports submitted per year:

Common Premarin and Paraflex drug interactions by gender *:
female:
- Anaphylactic reaction
- Body temperature increased
- Incoherent
- Influenza like illness
- Rash
- Splenomegaly
- Tryptase increased
- Abdominal distension
- Drug hypersensitivity
- Hepatic cirrhosis
male:
n/a
Common Premarin and Paraflex drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Anaphylactic reaction
- Body temperature increased
- Incoherent
- Influenza like illness
- Rash
- Splenomegaly
- Tryptase increased
- Abdominal distension
- Drug hypersensitivity
- Hepatic cirrhosis
60+:
n/a
* Approximation only. Some reports may have incomplete information.
Do you take Premarin and Paraflex?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Drug side effects by duration, gender and age:
- Premarin side effects (97,936 reports)
- Paraflex side effects (229 reports)
Common Premarin drug interactions:
- Premarin and Provera: 28,154 reports
- Premarin and Prempro: 19,571 reports
- Premarin and Synthroid: 8,169 reports
- Premarin and Medroxyprogesterone acetate: 7,059 reports
- Premarin and Aspirin: 4,550 reports
- Premarin and Cycrin: 4,375 reports
- Premarin and Prednisone: 4,323 reports
- Premarin and Lipitor: 4,088 reports
- Premarin and Prilosec: 3,963 reports
- Premarin and Vioxx: 3,487 reports
Browse interactions between Premarin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse interactions between Paraflex and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on estrogens, conjugated and chlorzoxazone (the active ingredients of Premarin and Paraflex, respectively), and Premarin and Paraflex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Premarin and Paraflex.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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