Primidone and Pristiq drug interactions - from FDA reports


Drug interactions are reported among people who take Primidone and Pristiq together. This study is created by eHealthMe based on reports of 21 people who take Primidone and Pristiq from FDA, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on primidone and desvenlafaxine succinate (the active ingredients of Primidone and Pristiq, respectively), and Primidone and Pristiq (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. (latest outcomes from Primidone 6,115 users)

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. (latest outcomes from Pristiq 18,846 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Mar, 22, 2019

21 people who take Primidone, Pristiq are studied.

Number of reports submitted per year:

Primidone and Pristiq drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Condition
  2. Diarrhoea
  3. Dizziness
  4. Dysuria (painful or difficult urination)
  5. Micturition disorder (disease of passing urine)
1 - 6 months:


6 - 12 months:
  1. Drug effect decreased
1 - 2 years:
  1. Gastric disorder (disease of stomach)
2 - 5 years:


5 - 10 years:


10+ years:


not specified:
  1. Blood potassium decreased
  2. Heart rate irregular
  3. Lower limb fracture
  4. Pain
  5. Renal failure acute (rapid kidney dysfunction)
  6. Thrombosis (formation of a blood clot inside a blood vessel)
  7. Tinnitus (a ringing in the ears)
  8. Condition
  9. Fatigue (feeling of tiredness)
  10. Arthropod sting (arthropod bite)

Most common drug interactions by gender *:

  1. Lower limb fracture
  2. Renal failure acute (rapid kidney dysfunction)
  3. Fatigue (feeling of tiredness)
  4. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  5. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  6. Headache (pain in head)
  7. Muscular weakness (muscle weakness)
  8. Visual impairment
  9. Antipsychotic drug level increased
  10. Chronic inflammatory demyelinating polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord)

Most common drug interactions by age *:









  1. Abnormal dreams
  2. Condition
  3. Drug ineffective
  4. Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  1. Blood glucose decreased
  2. Blood glucose increased
  3. Blood potassium decreased
  4. Heart rate irregular
  5. Lower limb fracture
  6. Pain
  7. Renal failure acute (rapid kidney dysfunction)
  8. Thrombosis (formation of a blood clot inside a blood vessel)
  9. Tinnitus (a ringing in the ears)
  10. Arthropod sting (arthropod bite)
  1. Condition
  2. Diarrhoea
  3. Hypersomnia (excessive daytime sleepiness (eds))
  4. Metastases to bone (cancer spreads to bone)
  5. Metastases to liver (cancer spreads to liver)
  6. Nausea (feeling of having an urge to vomit)
  7. Sinusitis (inflammation of sinus)
  8. Somnolence (a state of near-sleep, a strong desire for sleep)
  9. Stomatitis (inflammation of mucous membrane of mouth)
  10. Abdominal pain

* Approximation only. Some reports may have incomplete information.

Do you take Primidone and Pristiq?

You are not alone:

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Interactions between Primidone and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Pristiq and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Primidone and Pristiq
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Primidone and Pristiq (4,096 reports studied)

FDA reports used in this study

Recent updates

Recent general studies
Recent personal studies

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.