Protonix and Pennsaid drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Protonix and Pennsaid. Common interactions include chronic kidney disease among females and chronic kidney disease among males.
The phase IV clinical study analyzes what interactions people who take Protonix and Pennsaid have. It is created by eHealthMe based on reports of 72 people who take Protonix and Pennsaid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
72 people who take Protonix and Pennsaid together, and have interactions are studied.
What is Protonix?
Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 127,294 Protonix users for its effectiveness, alternative drugs and more.
What is Pennsaid?
Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,623 Pennsaid users for its effectiveness, alternative drugs and more.
Number of Protonix and Pennsaid reports submitted per year:

Common Protonix and Pennsaid drug interactions by gender *:
female:
- Chronic kidney disease
- Renal failure
- Pain
- Pain in extremity
- Tubulointerstitial nephritis
- Arthralgia
- Atrial fibrillation
- Cardiovascular disorder
- Hypertension
- Dementia
male:
- Chronic kidney disease
- Renal failure
- Renal injury
- Dyspepsia
- Nephrogenic anaemia
- Tubulointerstitial nephritis
- Renal artery stenosis
- Renal impairment
- Renal artery arteriosclerosis
- Nasopharyngitis
Common Protonix and Pennsaid drug interactions by age *:
0-1:
n/a
2-9:
- Depression
- Multiple fractures
- Osteonecrosis
- Osteoporosis
- Pain in extremity
- Ruptured cerebral aneurysm
- Scoliosis
- Foetal exposure during pregnancy
- Foot fracture
- Renal failure
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Dyskinesia
- Dysphagia
- Exercise tolerance decreased
- Fatigue
- Headache
- Hyperchlorhydria
- Hypersomnia
- Hypokinesia
- Infection
- Insomnia
50-59:
- Chronic kidney disease
- Renal failure
- Tubulointerstitial nephritis
- Renal injury
- Atrial fibrillation
- Cardiovascular disorder
- Hypertension
- Dyspepsia
- Nephrogenic anaemia
- Suicidal ideation
60+:
- Chronic kidney disease
- Renal failure
- Diarrhoea
- Drug ineffective
- Dysaesthesia
- Hyperlipidaemia
- Hypoaesthesia
- Impaired fasting glucose
- Intervertebral disc degeneration
- Migraine
Common conditions people have *:
- Pain: 26 people, 36.11%
- Stress And Anxiety: 18 people, 25.00%
- Depression: 17 people, 23.61%
- High Blood Cholesterol: 16 people, 22.22%
- Neuralgia (pain in one or more nerves): 14 people, 19.44%
- Muscle Spasms (muscle contraction): 13 people, 18.06%
- High Blood Pressure: 11 people, 15.28%
- Asthma: 10 people, 13.89%
- Inflammation: 10 people, 13.89%
- Osteoarthritis (a joint disease caused by cartilage loss in a joint): 10 people, 13.89%
* Approximation only. Some reports may have incomplete information.
Do you take Protonix and Pennsaid?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
Browse all drug interactions of Protonix and Pennsaid:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Protonix side effects:
- Chronic kidney disease: 41,674 reports
- Acute kidney failure: 15,351 reports
- Pain: 6,681 reports
- Fatigue (feeling of tiredness): 6,431 reports
- Breathing difficulty: 5,536 reports
- Diarrhea: 5,532 reports
Browse all side effects of Protonix:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Pennsaid side effects:
- Rashes (redness): 257 reports
- Drug ineffective: 253 reports
- Pain: 173 reports
- Joint pain: 128 reports
- Itching: 118 reports
Browse all side effects of Pennsaid:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Protonix interactions:
- Protonix and Nexium: 47,449 reports
- Protonix and Prilosec: 44,471 reports
- Protonix and Prevacid: 42,574 reports
- Protonix and Nexium 24hr: 29,743 reports
- Protonix and Dexilant: 28,649 reports
- Protonix and Prevacid 24 hr: 23,707 reports
- Protonix and Prilosec otc: 23,198 reports
- Protonix and Aspirin: 19,201 reports
- Protonix and Omeprazole: 15,717 reports
- Protonix and Lisinopril: 13,604 reports
Browse all interactions between Protonix and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Pennsaid interactions:
- Pennsaid and Gabapentin: 203 reports
- Pennsaid and Aspirin: 198 reports
- Pennsaid and Vitamin d: 191 reports
- Pennsaid and Prednisone: 181 reports
- Pennsaid and Omeprazole: 170 reports
- Pennsaid and Tramadol: 165 reports
- Pennsaid and Lyrica: 157 reports
- Pennsaid and Methotrexate: 147 reports
- Pennsaid and Cymbalta: 144 reports
- Pennsaid and Synthroid: 143 reports
Browse all interactions between Pennsaid and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on pantoprazole sodium and diclofenac sodium (the active ingredients of Protonix and Pennsaid, respectively), and Protonix and Pennsaid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Protonix and Pennsaid.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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