Rybelsus and Xigduo xr drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported only by a few people who take Rybelsus and Xigduo xr together.
The phase IV clinical study analyzes what interactions people who take Rybelsus and Xigduo xr have. It is created by eHealthMe based on reports of 5 people who take the same drugs from the FDA, and is updated regularly.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
5 people who take Rybelsus and Xigduo xr together, and have interactions are studied.
What is Rybelsus?
Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 1,902 Rybelsus users for its effectiveness, alternative drugs and more.
What is Xigduo xr?
Xigduo xr has active ingredients of dapagliflozin propanediol; metformin hydrochloride. eHealthMe is studying from 2,219 Xigduo xr users for its effectiveness, alternative drugs and more.
Number of Rybelsus and Xigduo xr reports submitted per year:

Common Rybelsus and Xigduo Xr drug interactions by gender *:
female:
- Necrotising fasciitis
- Vision blurred
male:
- Constipation
- Diarrhoea
- Faecaloma
- Injection site pruritus
- Ketosis
- Nausea
- Nodule
- Vomiting
Common Rybelsus and Xigduo Xr drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Ketosis
- Nausea
- Vomiting
30-39:
n/a
40-49:
n/a
50-59:
- Injection site pruritus
- Necrotising fasciitis
- Nodule
60+:
- Constipation
- Diarrhoea
- Faecaloma
- Vision blurred
* Approximation only. Some reports may have incomplete information.
Do you take Rybelsus and Xigduo xr?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
Browse all drug interactions of Rybelsus and Xigduo xr:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Rybelsus side effects:
- Diarrhea: 145 reports
Browse all side effects of Rybelsus:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Xigduo xr side effects:
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 251 reports
- Fatigue (feeling of tiredness): 126 reports
- Weight decreased: 119 reports
Browse all side effects of Xigduo xr:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Rybelsus interactions:
- Rybelsus and Metformin: 237 reports
Browse all interactions between Rybelsus and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Xigduo xr interactions:
- Xigduo xr and Metformin: 335 reports
- Xigduo xr and Lisinopril: 169 reports
- Xigduo xr and Trulicity: 165 reports
- Xigduo xr and Aspirin: 162 reports
- Xigduo xr and Bydureon: 109 reports
- Xigduo xr and Farxiga: 107 reports
Browse all interactions between Xigduo xr and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on semaglutide and dapagliflozin propanediol; metformin hydrochloride (the active ingredients of Rybelsus and Xigduo xr, respectively), and Rybelsus and Xigduo xr (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Rybelsus and Xigduo xr.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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