Simbrinza and Xtandi drug interactions - from FDA reports


Drug interactions are reported among people who take Simbrinza and Xtandi together. This study is created by eHealthMe based on reports of 13 people who take Simbrinza and Xtandi from FDA, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on brimonidine tartrate; brinzolamide and enzalutamide (the active ingredients of Simbrinza and Xtandi, respectively), and Simbrinza and Xtandi (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Simbrinza?

Simbrinza has active ingredients of brimonidine tartrate; brinzolamide. (latest outcomes from Simbrinza 1,535 users)

What is Xtandi?

Xtandi has active ingredients of enzalutamide. (latest outcomes from Xtandi 39,997 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Mar, 24, 2019

13 people who take Simbrinza, Xtandi are studied.

Number of reports submitted per year:

Simbrinza and Xtandi drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Drug ineffective
  2. Hypertension (high blood pressure)
1 - 6 months:
  1. Asthenia (weakness)
  2. Communication disorder (speech and language disorder)
  3. Weight decreased
  4. Confusional state
  5. Drug ineffective
  6. Failure to thrive (inadequate weight gain and physical growth in children)
  7. Fatigue (feeling of tiredness)
  8. General physical health deterioration (weak health status)
  9. Pain in extremity
  10. Prostatic specific antigen increased
6 - 12 months:


1 - 2 years:


2 - 5 years:


5 - 10 years:


10+ years:


not specified:
  1. Prostatic specific antigen increased
  2. Decreased appetite
  3. Nausea (feeling of having an urge to vomit)
  4. Asthenia (weakness)
  5. Fatigue (feeling of tiredness)
  6. Anaemia (lack of blood)
  7. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  8. Eye infection
  9. Gout (uric acid crystals building up in the body)
  10. Macular degeneration (painless eye condition that leads to the gradual loss of central vision)

Most common drug interactions by gender *:



Most common drug interactions by age *:















  1. Fatigue (feeling of tiredness)
  2. Prostatic specific antigen increased
  3. Nausea (feeling of having an urge to vomit)
  4. Renal artery stenosis (narrowing of renal artery)
  5. Renal impairment (severely reduced kidney function)
  6. Vertigo
  7. Deafness unilateral
  8. Speech disorder
  9. Anxiety
  10. Back disorder

* Approximation only. Some reports may have incomplete information.

Do you take Simbrinza and Xtandi?

You are not alone, use our "Ginger Health" app to:

  • connect with people like you who take Simbrinza and Xtandi
  • use your healthcare experience to help people like you, and be rewarded

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Interactions between Simbrinza and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Xtandi and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Simbrinza and Xtandi
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Simbrinza and Xtandi (738.0 reports studied)

FDA reports used in this study

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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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