Sinemet and Dilantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sinemet and Dilantin. Common interactions include ammonia increased among females and stevens-johnson syndrome among males.

The phase IV clinical study analyzes what interactions people who take Sinemet and Dilantin have. It is created by eHealthMe based on reports of 74 people who take Sinemet and Dilantin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Dec, 02, 2022

74 people who take Sinemet and Dilantin together, and have interactions are studied.


What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 26,820 Sinemet users for its effectiveness, alternative drugs and more.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,839 Dilantin users for its effectiveness, alternative drugs and more.

Number of Sinemet and Dilantin reports submitted per year:

Sinemet and Dilantin drug interactions.

Common Sinemet and Dilantin drug interactions by gender *:

female:

  1. Ammonia increased
  2. Blood thyroid stimulating hormone increased
  3. Cardiac failure congestive
  4. Cerebrovascular accident
  5. Coma
  6. Confusion
  7. Dementia of the alzheimer's type
  8. Depressed level of consciousness
  9. Dizziness
  10. Eye haemorrhage

male:

  1. Stevens-johnson syndrome
  2. Hepatic enzyme increased
  3. Loss of consciousness
  4. Pyrexia
  5. Sepsis
  6. Staphylococcal infection
  7. Thrombocytopenia
  8. Urinary tract infection
  9. Dysphagia
  10. Hypokinesia

Common Sinemet and Dilantin drug interactions by age *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Dysphagia
  2. Hypokinesia

40-49:

  1. Stevens-johnson syndrome
  2. Hepatic enzyme increased
  3. Pyrexia
  4. Deep vein thrombosis
  5. Device occlusion
  6. Oedema
  7. Pelvic venous thrombosis
  8. Thrombophlebitis superficial
  9. Vena cava thrombosis

50-59:

  1. Hiatus hernia
  2. Influenza
  3. Influenza like illness
  4. Injection site mass
  5. Injection site pain
  6. Injection site vesicles
  7. Malaise
  8. Muscle cramp
  9. Muscle fatigue
  10. Nasopharyngitis

60+:

  1. Convulsion
  2. Blood glucose increased
  3. Visual acuity reduced
  4. Ammonia increased
  5. Disorientation
  6. Drug rash with eosinophilia and systemic symptoms
  7. Ecchymosis
  8. Eye irritation
  9. Fall
  10. Hyponatraemia

Common conditions people have *:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 10.81%
  2. High Blood Pressure: 7 people, 9.46%
  3. Psoriasis (immune-mediated disease that affects the skin): 6 people, 8.11%
  4. Pain: 6 people, 8.11%
  5. High Blood Cholesterol: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and Dilantin?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Common Sinemet and Dilantin interactions:

Browse all drug interactions of Sinemet and Dilantin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Sinemet interactions:

Browse all interactions between Sinemet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Dilantin interactions:

Browse all interactions between Dilantin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa and phenytoin sodium (the active ingredients of Sinemet and Dilantin, respectively), and Sinemet and Dilantin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Sinemet and Dilantin.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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