Spironolactone and Amlodipine drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Spironolactone and Amlodipine together. This study is created by eHealthMe based on reports of 3,511 people who take Spironolactone and Amlodipine from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on spironolactone and amlodipine besylate (the active ingredients of Spironolactone and Amlodipine, respectively), and Spironolactone and Amlodipine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. (latest outcomes from Spironolactone 61,531 users)

What is Amlodipine?

Amlodipine has active ingredients of amlodipine besylate. It is often used in high blood pressure. (latest outcomes from Amlodipine 158,215 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Mar, 04, 2019

3,511 people who take Spironolactone, Amlodipine are studied.


Number of reports submitted per year:

Spironolactone and Amlodipine drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Diarrhoea
  2. Pruritus (severe itching of the skin)
  3. Blood urea increased
  4. C-reactive protein increased
  5. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  6. Anaemia (lack of blood)
  7. Hyperkalaemia (damage to or disease of the kidney)
  8. Incision site pain
  9. Lymphocyte count decreased
  10. Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
1 - 6 months:
  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Abdominal pain
  3. Sepsis (a severe blood infection that can lead to organ failure and death)
  4. Septic shock (shock due to blood infection)
  5. Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
  6. Constipation
  7. Lower respiratory tract infection
  8. Neutropenia (an abnormally low number of neutrophils)
  9. Pneumonia
  10. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
6 - 12 months:
  1. Hypotension (abnormally low blood pressure)
  2. Abdominal pain
  3. Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Back pain
  6. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  7. Constipation
  8. Lower respiratory tract infection
  9. Neuropathy peripheral (surface nerve damage)
  10. Neutropenia (an abnormally low number of neutrophils)
1 - 2 years:
  1. Hypotension (abnormally low blood pressure)
  2. Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
  3. Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
  4. Sinus bradycardia (an unusually slow heartbeat due to heart disease)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Anaemia (lack of blood)
  7. Hallucination (an experience involving the perception of something not present)
  8. Skin tightness
  9. Diarrhoea
  10. Thrombocytopenia (decrease of platelets in blood)
2 - 5 years:
  1. Chest pain
  2. Dehydration (dryness resulting from the removal of water)
  3. Head injury
  4. Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
  5. Hyperbilirubinaemia (excess of bilirubin in the blood)
  6. Large cell carcinoma of the respiratory tract stage unspecified (lung cancer of large cells unspecified)
  7. Loss of consciousness
  8. Nephropathy (damage to or disease of a kidney)
  9. Pancreatitis acute (sudden inflammation of pancreas)
  10. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
5 - 10 years:
  1. Chronic kidney disease
  2. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  3. Renal failure acute (rapid kidney dysfunction)
  4. Anaemia (lack of blood)
  5. Renal failure (kidney dysfunction)
  6. Bradyarrhythmia (heart slowness)
  7. Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
  8. Gastric ulcer (stomach ulcer)
  9. Renal impairment (severely reduced kidney function)
  10. Weight decreased
10+ years:
  1. Dizziness
  2. Hypotension (abnormally low blood pressure)
  3. Fluid overload (too much fluid in the blood)
  4. Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
  5. Cardiac failure congestive
  6. Cardiomegaly (increased size of heart than normal)
  7. Gastric bypass
  8. Pneumonia
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
not specified:
  1. Dyspnoea (difficult or laboured respiration)
  2. Nausea (feeling of having an urge to vomit)
  3. Diarrhoea
  4. Fatigue (feeling of tiredness)
  5. Dizziness
  6. Fall
  7. Drug ineffective
  8. Hypotension (abnormally low blood pressure)
  9. Anaemia (lack of blood)
  10. Pneumonia

Most common drug interactions by gender *:

female:
  1. Pneumonia
  2. Arthralgia (joint pain)
  3. Vomiting
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Anaemia (lack of blood)
  6. Drug ineffective
  7. Gait disturbance
  8. Headache (pain in head)
  9. Asthenia (weakness)
  10. Peripheral swelling
male:
  1. Dyspnoea (difficult or laboured respiration)
  2. Diarrhoea
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Anaemia (lack of blood)
  5. Asthenia (weakness)
  6. Renal impairment (severely reduced kidney function)
  7. Death
  8. Chest pain
  9. Cardiac failure
  10. Renal failure acute (rapid kidney dysfunction)

Most common drug interactions by age *:

0-1:
  1. Drug ineffective
  2. Lung disorder (lung disease)
  3. Respiratory failure (inadequate gas exchange by the respiratory system)
  4. Thrombocytopenia (decrease of platelets in blood)
  5. Proteinuria (presence of protein in the urine)
  6. Pulmonary embolism (blockage of the main artery of the lung)
  7. Anaemia (lack of blood)
  8. Disease progression
  9. Dyspnoea (difficult or laboured respiration)
  10. Hepatomegaly (abnormal enlargement of the liver)
2-9:
  1. Drug ineffective
  2. Brain natriuretic peptide increased
  3. Cardiac failure
  4. Cardiomegaly (increased size of heart than normal)
  5. Condition
  6. Disease progression
  7. Face oedema (swelling of face)
  8. General physical health deterioration (weak health status)
  9. Generalised oedema (swelling all over the body)
  10. Hepatomegaly (abnormal enlargement of the liver)
10-19:
  1. Pain in extremity
  2. Nasopharyngitis (inflammation of the nasopharynx)
  3. Dyspnoea (difficult or laboured respiration)
  4. Dyspnoea exertional (breathlessness or shortness of breath)
  5. Abdominal distension
  6. Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
  7. Fatigue (feeling of tiredness)
  8. Headache (pain in head)
  9. Heart rate increased
  10. Influenza
30-39:
  1. Headache (pain in head)
  2. Nausea (feeling of having an urge to vomit)
  3. Alanine aminotransferase increased
  4. Chest pain
  5. Dizziness
  6. Dyspnoea (difficult or laboured respiration)
  7. Erythema (redness of the skin)
  8. Palpitations (feelings or sensations that your heart is pounding or racing)
  9. Pruritus (severe itching of the skin)
  10. Rash
40-49:
  1. Headache (pain in head)
  2. Nausea (feeling of having an urge to vomit)
  3. Haemoglobin decreased
  4. Chest pain
  5. Drug ineffective
  6. Fatigue (feeling of tiredness)
  7. Pain
  8. Pain in extremity
  9. Pulmonary embolism (blockage of the main artery of the lung)
  10. Diarrhoea
50-59:
  1. Diarrhoea
  2. Rectal haemorrhage (bleeding from anus)
  3. Vomiting
  4. Asthenia (weakness)
  5. Pain
  6. Fatigue (feeling of tiredness)
  7. Renal impairment (severely reduced kidney function)
  8. Dizziness
  9. Anaemia (lack of blood)
  10. Malaise (a feeling of general discomfort or uneasiness)
60+:
  1. Dyspnoea (difficult or laboured respiration)
  2. Nausea (feeling of having an urge to vomit)
  3. Cardiac failure
  4. Oedema peripheral (superficial swelling)
  5. Asthenia (weakness)
  6. Renal failure (kidney dysfunction)
  7. Vomiting
  8. Drug ineffective
  9. Renal impairment (severely reduced kidney function)
  10. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and Amlodipine?


You are not alone:




Related publications that referenced our studies

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Spironolactone and drugs from A to Z
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Interactions between Amlodipine and drugs from A to Z
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Browse all drug interactions of Spironolactone and Amlodipine
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What would happen?

Predict new side effects and undetected conditions when you take Spironolactone and Amlodipine (42,613 reports studied)



FDA reports used in this study


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