St. john's wort and Excedrin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported only by a few people who take St. john's wort and Excedrin together.
The phase IV clinical study analyzes what interactions people who take St. john's wort and Excedrin have. It is created by eHealthMe based on reports of 3 people who take the same drugs from the FDA, and is updated regularly.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
3 people who take St. john's wort and Excedrin together, and have interactions are studied.
What is St. john's wort?
St. john's wort has active ingredients of st. john's wort. It is often used in depression. eHealthMe is studying from 692 St. john's wort users for its effectiveness, alternative drugs and more.
What is Excedrin?
Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 20,744 Excedrin users for its effectiveness, alternative drugs and more.
Number of St. john's wort and Excedrin reports submitted per year:

Common St. John'S Wort and Excedrin drug interactions by gender *:
female:
- Gastrointestinal haemorrhage
- Ill-defined disorder
- Peptic ulcer
male:
- Aura
- Burning sensation
- Urethral disorder
- Arthritis
- Back disorder
- Bursitis
- Coma
- Crying
- Dislocation of vertebra
- Drug abuse
Common St. John'S Wort and Excedrin drug interactions by age *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
n/a
60+:
- Gastrointestinal haemorrhage
- Ill-defined disorder
- Peptic ulcer
* Approximation only. Some reports may have incomplete information.
Do you take St. john's wort and Excedrin?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
Alternative drugs to, pros and cons of the 2 drugs:
- St. john's wort (692 reports)
- Excedrin (20,744 reports)
Browse all drug interactions of St. john's wort and Excedrin:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Excedrin side effects:
- Drug ineffective: 4,396 reports
- Headache (pain in head): 1,522 reports
- Fatigue (feeling of tiredness): 867 reports
- Pain: 823 reports
- Dizziness: 819 reports
- Migraine (headache): 745 reports
- Nausea and vomiting: 666 reports
Browse all side effects of Excedrin:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Excedrin interactions:
- Excedrin and Ibu: 1,327 reports
- Excedrin and Profen: 1,317 reports
- Excedrin and Tylenol: 1,168 reports
- Excedrin and Aspirin: 983 reports
- Excedrin and Vitamin d: 927 reports
- Excedrin and Xyrem: 863 reports
- Excedrin and Omeprazole: 741 reports
- Excedrin and Gabapentin: 654 reports
- Excedrin and Prednisone: 640 reports
- Excedrin and Lisinopril: 567 reports
Browse all interactions between Excedrin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on st. john's wort and acetaminophen; aspirin; caffeine (the active ingredients of St. john's wort and Excedrin, respectively), and St. john's wort and Excedrin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides St. john's wort and Excedrin.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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