Treximet and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Treximet and Methotrexate. Common interactions include dizziness among females and injection site mass among males.

The phase IV clinical study analyzes what interactions people who take Treximet and Methotrexate have. It is created by eHealthMe based on reports of 25 people who take Treximet and Methotrexate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Oct, 01, 2022

25 people who take Treximet and Methotrexate together, and have interactions are studied.


What is Treximet?

Treximet has active ingredients of naproxen sodium; sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 1,852 Treximet users for its effectiveness, alternative drugs and more.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 521,798 Methotrexate users for its effectiveness, alternative drugs and more.

Number of Treximet and Methotrexate reports submitted per year:

Treximet and Methotrexate drug interactions.

Common Treximet and Methotrexate drug interactions by gender *:

female:

  1. Dizziness
  2. Anaemia
  3. Anxiety
  4. Biliary dyskinesia
  5. Depression
  6. Dry mouth
  7. Dyspnoea
  8. Fungal infection
  9. Gallbladder disorder
  10. Gastrointestinal disorder

male:

  1. Injection site mass

Common Treximet and Methotrexate drug interactions by age *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Biliary dyskinesia
  2. Gallbladder disorder
  3. Organ failure
  4. Injury
  5. Pain

30-39:

  1. Fear of disease
  2. Injury
  3. Pain
  4. Pleural effusion
  5. Pleuritic pain
  6. Pneumonia
  7. Pulmonary embolism
  8. Pulmonary fibrosis

40-49:

  1. Dizziness
  2. Abdominal discomfort
  3. Fatigue
  4. Headache
  5. Tongue discolouration
  6. Malaise
  7. Rash
  8. Stress
  9. Hepatic enzyme increased
  10. Injection site inflammation

50-59:

  1. Asthenia
  2. Diarrhoea
  3. Drug ineffective
  4. Foot fracture
  5. Injection site pain
  6. Somnolence
  7. Therapeutic response unexpected

60+:

  1. Abdominal discomfort
  2. Adverse drug reaction
  3. Injection site pruritus
  4. Nausea
  5. Osteoarthritis
  6. Physical disability
  7. Vomiting
  8. Chondropathy
  9. Cold sweat
  10. Dizziness

Common conditions people have *:

  1. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 12.00%
  2. Pain: 3 people, 12.00%
  3. Insomnia (sleeplessness): 3 people, 12.00%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
  5. Depression: 3 people, 12.00%
  6. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.00%
  7. Gingival Infection (gum infection): 2 people, 8.00%
  8. Birth Control: 2 people, 8.00%
  9. Amenorrhea (absence of a menstrual period in a woman of reproductive age): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Treximet and Methotrexate?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



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Alternative drugs to, pros and cons of the 2 drugs:

Browse all drug interactions of Treximet and Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Treximet interactions:

Browse all interactions between Treximet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common Methotrexate interactions:

Browse all interactions between Methotrexate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on naproxen sodium; sumatriptan succinate and methotrexate sodium (the active ingredients of Treximet and Methotrexate, respectively), and Treximet and Methotrexate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study. Patients in the study may take other drugs besides Treximet and Methotrexate.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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