Trokendi xr and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trokendi xr and Metformin. Common interactions include headache among females and choking among males.

The phase IV clinical study analyzes what interactions people who take Trokendi xr and Metformin have. It is created by eHealthMe based on reports of 38 people who take Trokendi xr and Metformin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 09, 2023

38 people who take Trokendi xr and Metformin together, and have interactions are studied.

What is Trokendi xr?

Trokendi xr has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 1,636 Trokendi xr users for its effectiveness, alternative drugs and more.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 406,224 Metformin users for its effectiveness, alternative drugs and more.

Number of Trokendi xr and Metformin reports submitted per year:

Common Trokendi Xr and Metformin drug interactions by gender *:

female:

Headache
Drug ineffective
Urticaria
Cough
Hypoaesthesia
Insomnia
Anxiety
Eye pain
Herpes zoster
Hypersensitivity

male:

Choking
Cough
Drug administration error
Oropharyngeal pain
Drug ineffective
Seizure

Common Trokendi Xr and Metformin drug interactions by age *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Confusional state
Drug withdrawal convulsions
Dysgeusia
Headache
Injection site erythema
Injection site pain
Injection site reaction
Paraesthesia
Urticaria

40-49:

Chronic kidney disease
Drug ineffective
Nausea
Asthenia
Chest discomfort
Dizziness
Dysphemia
Dyspnoea
Fatigue
Fluid retention

50-59:

Cough
Therapeutic response unexpected
Weight decreased
Weight increased
Adjustment disorder with depressed mood
Blood glucose increased
Multiple sclerosis relapse
Skin warm
Surgery
Abdominal pain

60+:

Abdominal discomfort
Diarrhoea
Blood disorder
Chest discomfort
Dry mouth
Flatulence
Gait disturbance
Vascular injury
Malaise
Alopecia

Common conditions people have *:

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 10.53%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.53%
Weight Decreased: 3 people, 7.89%
Neuralgia (pain in one or more nerves): 3 people, 7.89%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 7.89%
Headache (pain in head): 3 people, 7.89%
Stress And Anxiety: 2 people, 5.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.26%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 5.26%
Pain: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Trokendi xr and Metformin?

Personalize this study to your gender and age

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .

Related studies

Alternative drugs to, pros and cons of the 2 drugs:

Trokendi xr (1,636 reports)
Metformin (406,224 reports)