Ultram and Melatonin drug interactions - from FDA reports


Drug interactions are reported among people who take Ultram and Melatonin together. This study is created by eHealthMe based on reports of 165 people who take Ultram and Melatonin from FDA, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on tramadol hydrochloride and melatonin (the active ingredients of Ultram and Melatonin, respectively), and Ultram and Melatonin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Ultram 22,088 users)

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 18,393 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Feb, 21, 2019

165 people who take Ultram, Melatonin are studied.

Number of reports submitted per year:

Ultram and Melatonin drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Cardiac failure
  3. Cardiogenic shock (inadequate circulation of blood)
  4. Cellulitis (infection under the skin)
  5. Dizziness
  6. Dyspnoea (difficult or laboured respiration)
  7. Fluid overload (too much fluid in the blood)
  8. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  9. Haematuria (presence of blood in urine)
  10. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
1 - 6 months:


6 - 12 months:


1 - 2 years:


2 - 5 years:
  1. Cellulitis (infection under the skin)
  2. Fungal skin infection
  3. Nausea (feeling of having an urge to vomit)
  4. Pneumonia
  5. Sepsis (a severe blood infection that can lead to organ failure and death)
  6. Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)
  7. Urinary tract infection
5 - 10 years:


10+ years:


not specified:
  1. Vision blurred
  2. Intervertebral disc protrusion (spinal disc protrusion)
  3. Psychomotor hyperactivity (feelings of extreme restlessness)
  4. Skin ulcer
  5. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  6. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
  7. Breast cellulitis (spreading, acute inflammation of beast skin)
  8. Burning sensation
  9. Diarrhoea haemorrhagic (bloody diarrhoea)
  10. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

Most common drug interactions by gender *:

  1. Weight increased
  2. Abdominal pain
  3. Heart rate increased
  4. Abdominal pain upper
  5. Hyperhidrosis (abnormally increased sweating)
  6. Pain in extremity
  7. Drug ineffective
  8. Fall
  9. Hypoaesthesia (reduced sense of touch or sensation)
  10. Asthenia (weakness)
  1. Dyspnoea (difficult or laboured respiration)
  2. Condition
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Peripheral swelling
  5. Sepsis (a severe blood infection that can lead to organ failure and death)
  6. Sinusitis (inflammation of sinus)
  7. Tenderness (pain or discomfort when an affected area is touched)
  8. Asthenia (weakness)
  9. Abdominal distension
  10. Chills (felling of cold)

Most common drug interactions by age *:





  1. Arthralgia (joint pain)
  2. Gait disturbance
  3. Headache (pain in head)
  4. Abdominal pain upper
  5. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  6. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  7. Anxiety
  8. Constipation
  9. Dyspepsia (indigestion)
  10. Dyspnoea (difficult or laboured respiration)
  1. Nausea (feeling of having an urge to vomit)
  2. Vomiting
  3. Abdominal pain
  4. Diarrhoea
  5. Pneumonia
  6. Anaemia (lack of blood)
  7. Chills (felling of cold)
  8. Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
  9. Constipation
  10. Electrocardiogram qt prolonged
  1. Arthralgia (joint pain)
  2. Depression
  3. Psychomotor hyperactivity (feelings of extreme restlessness)
  4. Headache (pain in head)
  5. Accident at work
  6. Anger
  7. Blood creatinine increased
  8. Cervicobrachial syndrome (pain in neck and arm with changing location)
  9. Lumbar radiculopathy (radicular pain in the low back and legs)
  10. Menstrual disorder (disease of menstrual cycle)
  1. Nausea (feeling of having an urge to vomit)
  2. Arthralgia (joint pain)
  3. Fatigue (feeling of tiredness)
  4. Constipation
  5. Headache (pain in head)
  6. Heart rate increased
  7. Dysphagia (condition in which swallowing is difficult or painful)
  8. Dyspnoea (difficult or laboured respiration)
  9. Hyperhidrosis (abnormally increased sweating)
  10. Weight increased
  1. Urinary tract infection
  2. Arthralgia (joint pain)
  3. Fatigue (feeling of tiredness)
  4. Gait disturbance
  5. Migraine (headache)
  6. Pulmonary hypertension (increase in blood pressure in the lung artery)
  7. Vomiting
  8. Weight increased
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  10. Cardiogenic shock (inadequate circulation of blood)
  1. Dyspnoea (difficult or laboured respiration)
  2. Asthenia (weakness)
  3. Pain in extremity
  4. Vomiting
  5. Anxiety
  6. Fatigue (feeling of tiredness)
  7. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  8. Hypotension (abnormally low blood pressure)
  9. Osteonecrosis of jaw (death of bone of jaw)
  10. Abdominal pain upper

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and Melatonin?

You are not alone:

Related publications that referenced our studies

Related studies

Browse interactions by gender and age

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Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Interactions between Ultram and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Melatonin and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Ultram and Melatonin
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Ultram and Melatonin

FDA reports used in this study

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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