Vitamin c and Vitamin b12 drug interactions - from FDA reports


Drug interactions are reported among people who take Vitamin c and Vitamin b12 together. This study is created by eHealthMe based on reports of 5,652 people who take Vitamin c and Vitamin b12 from FDA, and is updated regularly.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.

Who is eHealthMe: we are a data analysis company who specializes in health care industry. Our original studies have been referenced on 500+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and EANO. On eHealthMe, you can research drugs and monitor them (see testimonials). If you find eHealthMe useful, please help us to spread the words below or leave us a testimonial.



On Jan, 10, 2019

5,652 people who take Vitamin c, Vitamin b12 are studied.


Number of reports submitted per year:

Vitamin c and Vitamin b12 drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Depression
  2. Anxiety
  3. Cerebral disorder (brain disease)
  4. Ascites (accumulation of fluid in the abdominal cavity)
  5. Back pain
  6. Dyspnoea (difficult or laboured respiration)
  7. General physical health deterioration (weak health status)
  8. Malignant neoplasm of pleura (cancer tumour of lung covering)
  9. Malignant neoplasm progression (cancer tumour came back)
  10. Pleural effusion (water on the lungs)
1 - 6 months:
  1. Back pain
  2. Abdominal distension
  3. Confusional state
  4. Dehydration (dryness resulting from the removal of water)
  5. Immunodeficiency
  6. Memory impairment
  7. Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
  8. Opportunistic infection (a microorganism that normally does not cause disease but becomes pathogenic when the body's immune system is impaired and unable to fight)
  9. Oral candidiasis (fungal infection of mouth)
  10. Rash
6 - 12 months:
  1. Dyspepsia (indigestion)
  2. Live birth
  3. Maternal exposure during pregnancy (use of substance during pregnancy)
  4. Pain in extremity
  5. Placental disorder
  6. Respiratory tract infection
  7. Retained placenta or membranes (placenta in uterus)
  8. Anaphylactic reaction (serious allergic reaction)
  9. Anxiety
  10. Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
1 - 2 years:
  1. Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
  2. Respiratory failure (inadequate gas exchange by the respiratory system)
  3. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  4. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  5. Depression
  6. Suicidal ideation
  7. Feeling abnormal
  8. Memory impairment
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  10. Blood pressure increased
2 - 5 years:
  1. Hypoxia (low oxygen in tissues)
  2. Blood glucose increased
  3. Cardiac failure congestive
  4. Death
  5. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  6. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  7. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  8. Ovarian cyst (fluid filled sac of the ovary)
  9. Pre-existing condition improved
  10. Procedural pain
5 - 10 years:
  1. Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
  2. Death
  3. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  4. Hyperhidrosis (abnormally increased sweating)
  5. Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Weight decreased
10+ years:
  1. Bowen's disease (early stage of skin cancer)
  2. Drug ineffective
  3. C-reactive protein increased
  4. Cardiac murmur (an heart sound in valve abnormality)
  5. Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
  6. Constipation
  7. Delirium (wild excitement)
  8. Dry eye (lack of adequate tears)
  9. Dry mouth
  10. Dry skin
not specified:
  1. Diarrhoea
  2. Nausea (feeling of having an urge to vomit)
  3. Drug ineffective
  4. Headache (pain in head)
  5. Pain
  6. Dizziness
  7. Asthenia (weakness)
  8. Fall
  9. Dyspnoea (difficult or laboured respiration)
  10. Arthralgia (joint pain)

Most common drug interactions by gender *:

female:
  1. Dizziness
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Pain in extremity
  4. Asthenia (weakness)
  5. Dyspnoea (difficult or laboured respiration)
  6. Arthralgia (joint pain)
  7. Gait disturbance
  8. Insomnia (sleeplessness)
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Depression
male:
  1. Diarrhoea
  2. Drug ineffective
  3. Headache (pain in head)
  4. Fall
  5. Pain in extremity
  6. Pneumonia
  7. Decreased appetite
  8. Vomiting
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Death

Most common drug interactions by age *:

0-1:
  1. Cardiac failure congestive
  2. Cardiac murmur (an heart sound in valve abnormality)
  3. Cardiac output decreased
  4. Congenital cardiovascular anomaly (birth defect of heart vessels)
  5. Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
  6. Erythema (redness of the skin)
  7. Failure to thrive (inadequate weight gain and physical growth in children)
  8. Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Immature respiratory system
2-9:
  1. Febrile neutropenia (fever with reduced white blood cells)
  2. Weight decreased
  3. Cystitis (inflammation of the wall of the bladder)
  4. Kidney infection
10-19:
  1. Alopecia (absence of hair from areas of the body)
  2. Anxiety
  3. Arthralgia (joint pain)
  4. Dizziness
  5. Dyspnoea exertional (breathlessness or shortness of breath)
  6. Headache (pain in head)
  7. Hypotension (abnormally low blood pressure)
  8. Migraine (headache)
  9. Muscular weakness (muscle weakness)
  10. Nausea (feeling of having an urge to vomit)
20-29:
  1. Anxiety
  2. Pain
  3. Diarrhoea
  4. Nausea (feeling of having an urge to vomit)
  5. Back pain
  6. Feeling abnormal
  7. Abdominal pain upper
  8. Scar
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Pyrexia (fever)
30-39:
  1. Nausea (feeling of having an urge to vomit)
  2. Depression
  3. Headache (pain in head)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Fall
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  7. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  8. Hypertension (high blood pressure)
  9. Pneumonia
  10. Blood pressure fluctuation
40-49:
  1. Headache (pain in head)
  2. Nausea (feeling of having an urge to vomit)
  3. Pain
  4. Diarrhoea
  5. Dizziness
  6. Asthenia (weakness)
  7. Depression
  8. Insomnia (sleeplessness)
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Vomiting
50-59:
  1. Arthralgia (joint pain)
  2. Drug ineffective
  3. Vomiting
  4. Gait disturbance
  5. Anxiety
  6. Dyspnoea (difficult or laboured respiration)
  7. Depression
  8. Insomnia (sleeplessness)
  9. Hypoaesthesia (reduced sense of touch or sensation)
  10. Asthenia (weakness)
60+:
  1. Diarrhoea
  2. Nausea (feeling of having an urge to vomit)
  3. Pain in extremity
  4. Fall
  5. Weight decreased
  6. Pneumonia
  7. Somnolence (a state of near-sleep, a strong desire for sleep)
  8. Constipation
  9. Cough
  10. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



Do you take Vitamin c and Vitamin b12?


You are not alone:




Related studies

Vitamin c

Vitamin c has active ingredients of l-ascorbic acid. It is often used in vitamin supplementation. (latest outcomes from Vitamin c 35,692 users)

Vitamin b12

Vitamin b12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. (latest outcomes from Vitamin b12 52,249 users)


Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Vitamin c and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Interactions between Vitamin b12 and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Vitamin c and Vitamin b12
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Vitamin c and Vitamin b12 (8,958 reports studied)

Recent updates

Recent general studies
Recent personal studies

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Submit your testimonial

  • Please fill in your Testimonial.
  • Please enter a minimum of 10 characters for your Testimonial.
  • Please fill in your Name.

Please wait...

{progressItem}

Thank you!