Xeljanz and Synthroid drug interactions - from FDA reports

Drug interactions are reported among people who take Xeljanz and Synthroid together. This study is created by eHealthMe based on reports of 951 people who take Xeljanz and Synthroid from FDA, and is updated regularly.

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On Jan, 22, 2019

951 people who take Xeljanz, Synthroid are studied.

Number of reports submitted per year:

Xeljanz and Synthroid drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Headache (pain in head)
  2. Nasopharyngitis (inflammation of the nasopharynx)
  3. Cough
  4. Diarrhoea
  5. Pain
  6. Arthralgia (joint pain)
  7. Blood pressure increased
  8. Condition
  9. Sinusitis (inflammation of sinus)
  10. Vomiting
1 - 6 months:
  1. Fatigue (feeling of tiredness)
  2. Diarrhoea
  3. Cough
  4. Dizziness
  5. Pyrexia (fever)
  6. Oropharyngeal pain
  7. Throat irritation
  8. Urinary tract infection
  9. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  10. Rhinorrhoea (watery mucus discharge from the nose)
6 - 12 months:
  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Cataract (clouding of the lens inside the eye)
  3. Disease recurrence
  4. Dizziness
  5. Fall
  6. Kidney infection
  7. Lower respiratory tract infection
  8. Muscular weakness (muscle weakness)
  9. Peripheral swelling
  10. Platelet count decreased
2 - 5 years:
  1. Hepatic enzyme increased
  2. Back pain
  3. Blood creatine phosphokinase increased
  4. Condition
  5. Constipation
  6. Dehydration (dryness resulting from the removal of water)
  7. Delirium (wild excitement)
  8. Fungal infection
  9. Hypokinesia (decreased bodily movement)
  10. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
10+ years:


not specified:
  1. Drug ineffective
  2. Condition
  3. Joint swelling
  4. Arthralgia (joint pain)
  5. Pain
  6. Synovitis (inflammation of the synovial membrane)
  7. Fatigue (feeling of tiredness)
  8. Herpes zoster
  9. Blood cholesterol increased
  10. Arthritis (form of joint disorder that involves inflammation of one or more joints)

Most common drug interactions by gender *:

  1. Nausea (feeling of having an urge to vomit)
  2. Weight increased
  3. Sinusitis (inflammation of sinus)
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Anaemia (lack of blood)
  6. Cough
  7. Fall
  8. Nasopharyngitis (inflammation of the nasopharynx)
  9. Leukopenia (less number of white blood cells in blood)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  1. Drug ineffective
  2. Insomnia (sleeplessness)
  3. Myalgia (muscle pain)
  4. Anaemia of chronic disease
  5. Blood prolactin decreased
  6. Blood thyroid stimulating hormone decreased
  7. Constipation
  8. Essential hypertension (primary hypertension)
  9. Fibromyalgia (a long-term condition which causes pain all over the body)
  10. Herpes zoster

Most common drug interactions by age *:





  1. Cardiac arrest
  2. Acidosis (build-up of carbon dioxide in the blood)
  3. Memory impairment
  4. Oxygen saturation decreased
  5. Nausea (feeling of having an urge to vomit)
  6. Herpes zoster
  7. Hypersensitivity
  8. Infection
  9. Acne (skin problems that cause pimples)
  10. Arthralgia (joint pain)
  1. Drug ineffective
  2. Myalgia (muscle pain)
  3. Bone erosion
  4. Gait disturbance
  5. Synovitis (inflammation of the synovial membrane)
  6. Condition
  7. Muscle fatigue (a condition in which muscles cannot exert their normal force)
  8. Pelvic fracture
  9. Drug intolerance (drug sensitivity)
  10. Hypersensitivity
  1. Influenza
  2. Muscle spasms (muscle contraction)
  3. Pyrexia (fever)
  4. Sinusitis (inflammation of sinus)
  5. Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
  6. Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
  7. Pustular psoriasis (raised bumps on the skin that are filled with pus)
  8. Diarrhoea
  9. Abdominal pain upper
  10. Asthenia (weakness)
  1. Drug ineffective
  2. Arthralgia (joint pain)
  3. Pain in extremity
  4. Cough
  5. Diarrhoea
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  7. Nasopharyngitis (inflammation of the nasopharynx)
  8. Blood cholesterol increased
  9. Dizziness
  10. Sinusitis (inflammation of sinus)

* Approximation only. Some reports may have incomplete information.

Do you take Xeljanz and Synthroid?

You are not alone:

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What would happen?

Predict new side effects and undetected conditions when you take Xeljanz and Synthroid

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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