Xeloda and Benadryl drug interactions - from FDA reports


Drug interactions are reported among people who take Xeloda and Benadryl together. This study is created by eHealthMe based on reports of 442 people who take Xeloda and Benadryl from FDA, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on capecitabine and diphenhydramine hydrochloride (the active ingredients of Xeloda and Benadryl, respectively), and Xeloda and Benadryl (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Xeloda?

Xeloda has active ingredients of capecitabine. It is often used in breast cancer metastatic. (latest outcomes from Xeloda 35,541 users)

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 57,530 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Feb, 17, 2019

442 people who take Xeloda, Benadryl are studied.

Number of reports submitted per year:

Xeloda and Benadryl drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Diarrhoea
  2. Dyspnoea (difficult or laboured respiration)
  3. Nausea (feeling of having an urge to vomit)
  4. Death
  5. Dizziness
  6. Vomiting
  7. Asthenia (weakness)
  8. Chest pain
  9. Pyrexia (fever)
  10. Stomatitis (inflammation of mucous membrane of mouth)
1 - 6 months:
  1. Abdominal pain
  2. Syncope (loss of consciousness with an inability to maintain postural tone)
  3. Arthralgia (joint pain)
  4. Bone disorder
  5. Fatigue (feeling of tiredness)
  6. Impaired healing
  7. Pain in jaw
  8. Pleural effusion (water on the lungs)
  9. Animal bite
  10. Benign neoplasm of thyroid gland (benign (non-cancerous) tumours of the thyroid gland)
6 - 12 months:
  1. Abdominal pain
  2. Arthralgia (joint pain)
  3. Back pain
  4. Death
  5. Diarrhoea
  6. Disease progression
  7. Fatigue (feeling of tiredness)
  8. Metastases to liver (cancer spreads to liver)
  9. Abdominal discomfort
  10. Abdominal distension
1 - 2 years:
  1. Diarrhoea
  2. Alveolitis allergic (inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts)
  3. Muscle spasms (muscle contraction)
  4. Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
  5. Nausea (feeling of having an urge to vomit)
  6. Neoplasm (tumour)
  7. Oral herpes (viral infection of mouth)
  8. Platelet count decreased
  9. Prealbumin decreased
  10. Protein total decreased
2 - 5 years:


5 - 10 years:


10+ years:


not specified:
  1. Diarrhoea
  2. Death
  3. Fatigue (feeling of tiredness)
  4. Nausea (feeling of having an urge to vomit)
  5. Pain
  6. Dyspnoea (difficult or laboured respiration)
  7. Constipation
  8. Cough
  9. Back pain
  10. Vomiting

Most common drug interactions by gender *:

  1. Cough
  2. Metastases to bone (cancer spreads to bone)
  3. Constipation
  4. Vomiting
  5. Back pain
  6. Asthenia (weakness)
  7. Anaemia (lack of blood)
  8. Osteonecrosis of jaw (death of bone of jaw)
  9. Pleural effusion (water on the lungs)
  10. Weight decreased
  1. Death
  2. Diarrhoea
  3. Back pain
  4. Decreased appetite
  5. Dehydration (dryness resulting from the removal of water)
  6. Abdominal distension
  7. Pain
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Pulmonary embolism (blockage of the main artery of the lung)
  10. Hypertension (high blood pressure)

Most common drug interactions by age *:







  1. Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
  2. Blindness transient (sudden loss of vision)
  3. Cardiac failure congestive
  4. Cardiomyopathy acute (emotional or physical stress can cause rapid and severe heart muscle weakness)
  5. Chest pain
  6. Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
  7. Dyspnoea (difficult or laboured respiration)
  8. Ejection fraction decreased (systolic heart failure)
  9. Headache (pain in head)
  10. Muscle rigidity (muscle stiffness)
  1. Fatigue (feeling of tiredness)
  2. Dyspnoea (difficult or laboured respiration)
  3. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  4. Death
  5. Hypoaesthesia (reduced sense of touch or sensation)
  6. Lethargy (tiredness)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
  9. Nausea (feeling of having an urge to vomit)
  10. Pain
  1. Pain
  2. Pain in jaw
  3. Dyspnoea (difficult or laboured respiration)
  4. Fatigue (feeling of tiredness)
  5. Impaired healing
  6. Cough
  7. Decreased appetite
  8. Diarrhoea
  9. Asthenia (weakness)
  10. Abdominal pain
  1. Hypotension (abnormally low blood pressure)
  2. Nausea (feeling of having an urge to vomit)
  3. Anaemia (lack of blood)
  4. Back pain
  5. Dehydration (dryness resulting from the removal of water)
  6. Dizziness
  7. Fall
  8. Fatigue (feeling of tiredness)
  9. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  10. Anxiety
  1. Diarrhoea
  2. Nausea (feeling of having an urge to vomit)
  3. Pyrexia (fever)
  4. Back pain
  5. Weight decreased
  6. Metastases to bone (cancer spreads to bone)
  7. Dyspnoea (difficult or laboured respiration)
  8. Oedema peripheral (superficial swelling)
  9. Disease progression
  10. Epistaxis (bleed from the nose)

* Approximation only. Some reports may have incomplete information.

Do you take Xeloda and Benadryl?

You are not alone:

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Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Interactions between Xeloda and drugs from A to Z
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Interactions between Benadryl and drugs from A to Z
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Browse all drug interactions of Xeloda and Benadryl
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What would happen?

Predict new side effects and undetected conditions when you take Xeloda and Benadryl (20,662 reports studied)

FDA reports used in this study

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