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A study for a 68 year old woman who takes Letrozole - from FDA reports


6,177 females aged 68 (±5) who take the same drug are studied. This is a personalized study for a 68 year old female patient who has Her2-Positive Breast Cancer. The study is created by eHealthMe based on reports from FDA.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.


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On Feb, 11, 2019

6,177 females aged 68 (±5) who take Letrozole are studied.


Number of reports submitted per year:

Letrozole for a 68-year old woman.

Information of the patient in this study:

  • Age: 68
  • Gender: female
  • Conditions: Her2-Positive Breast Cancer
  • Drugs taken:
    • Letrozole (letrozole)

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

  • Sleeplessness(a sleep disorder in which there is an inability to fall asleep or to stay asleep as long as desired): 111 (1.8% of females aged 68 (±5) who take the drug)
  • Inflammation: 8 (0.13% of females aged 68 (±5) who take the drug)

As an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea

As an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea

Most common side effects over time

< 1 month:
  1. Joint pain
  2. Rashes (redness)
  3. Pain in extremity
  4. Hypotension (abnormally low blood pressure)
  5. Bone pain
  6. Itching
  7. Fatigue (feeling of tiredness)
  8. Pneumonia
  9. Death
  10. Oedema peripheral (superficial swelling)
1 - 6 months:
  1. Joint pain
  2. Fatigue (feeling of tiredness)
  3. Nausea (feeling of having an urge to vomit)
  4. Aspartate aminotransferase increased
  5. Alanine aminotransferase increased
  6. Weakness
  7. Muscle aches (muscle pain)
  8. Urinary tract infection
  9. Headache (pain in head)
  10. Dizziness
6 - 12 months:
  1. Joint pain
  2. Malignant neoplasm progression (cancer tumour came back)
  3. Bone pain
  4. Breathing difficulty
  5. Cough
  6. Weakness
  7. Fatigue (feeling of tiredness)
  8. Anaemia (lack of blood)
  9. Metastases to bone (cancer spreads to bone)
  10. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
1 - 2 years:
  1. Thrombocytosis
  2. Joint pain
  3. Fatigue (feeling of tiredness)
  4. Malignant neoplasm progression (cancer tumour came back)
  5. High blood pressure
  6. Hair loss
  7. Metastases to bone (cancer spreads to bone)
  8. Headache (pain in head)
  9. Death
  10. Fall
2 - 5 years:
  1. Joint pain
  2. Osteonecrosis of jaw (death of bone of jaw)
  3. Muscle aches (muscle pain)
  4. Weakness
  5. Metastases to bone (cancer spreads to bone)
  6. Bone pain
  7. Fatigue (feeling of tiredness)
  8. Lichen sclerosus (a skin disorder that causes the skin to become thin, whitened, wrinkled, and can cause itching and pain)
  9. Malignant neoplasm progression (cancer tumour came back)
  10. Axonal neuropathy (dysfunction of axon nerves)
5 - 10 years:
  1. Metastases to lung (cancer spreads to lung)
  2. Breathing difficulty
  3. Osteonecrosis of jaw (death of bone of jaw)
  4. Hair loss
  5. Hair texture abnormal
  6. Lumbar vertebral fracture
  7. Metastases to bone (cancer spreads to bone)
  8. Hair color changes
  9. Thoracic vertebral fracture
  10. Hair disorder
10+ years:
  1. Gallstones (stone formation by bile component)
  2. Splenomegaly (enlargement of spleen)
  3. Liver disorder (liver diseases)
  4. Death
  5. Pvt
not specified:
  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Pain
  4. White blood cell count decreased
  5. Diarrhea
  6. Hair loss
  7. Stress and anxiety
  8. Joint pain
  9. Weakness
  10. Breathing difficulty

Top conditions involved for these people *:

  1. Breast Cancer Female : 494 people, 8.00%
  2. High Blood Pressure : 419 people, 6.78%
  3. Metastases To Bone (cancer spreads to bone): 378 people, 6.12%
  4. Pain : 243 people, 3.93%
  5. High Blood Cholesterol : 233 people, 3.77%
  6. Neoplasm Malignant (cancer tumour): 193 people, 3.12%
  7. Breast Cancer Stage Iv : 142 people, 2.30%
  8. Depression : 134 people, 2.17%
  9. Osteoporosis (bones weak and more likely to break): 126 people, 2.04%
  10. Preventive Health Care : 125 people, 2.02%

Top co-used drugs for these people *:

  1. Ibrance (1,949 people, 31.55%)
  2. Zometa (662 people, 10.72%)
  3. Faslodex (268 people, 4.34%)
  4. Aredia (263 people, 4.26%)
  5. Calcium (260 people, 4.21%)
  6. Xgeva (258 people, 4.18%)
  7. Vitamin D (241 people, 3.90%)
  8. Metformin (237 people, 3.84%)
  9. Synthroid (221 people, 3.58%)
  10. Xeloda (212 people, 3.43%)

* Some reports may have incomplete information.

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FDA reports used in this study


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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