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A study for a 50 year old man who takes Flexeril, Gabapentin, Tramadol, Lisinopril - from FDA reports

304 males aged 50 (±5) who take the same drugs are studied. This is a personalized study for a 50 year old male patient who has Htn, Muscle Cramps, Chronic Pain, Neuropathy. The study is created by eHealthMe based on reports from FDA.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Peer support for this study is available on our Ginger Health app. It's free, anonymous and secure. The app is ideal for people taking multiple medications or having multiple conditions.

On Feb, 11, 2019

304 males aged 50 (±5) who take Flexeril, Gabapentin, Tramadol, Lisinopril are studied.

Number of reports submitted per year:

Flexeril, Gabapentin, Tramadol, Lisinopril for a 50-year old man.

Information of the patient in this study:

  • Age: 50
  • Gender: male
  • Conditions: Htn, Muscle Cramps, Chronic Pain, Neuropathy
  • Drugs taken:
    • Lisinopril (lisinopril)
    • Flexeril (cyclobenzaprine hydrochloride)
    • Tramadol (tramadol hydrochloride)
    • Gabapentin (gabapentin)

eHealthMe real world results:

Most common drug interactions over time

< 1 month:
  1. Angioedema (rapid swelling of the dermis)
  2. Hallucinations (sensations that appear real but are created by your mind)
  3. Polyarthritis (arthritis which involves 5 or more joints simultaneously)
  4. Lip swelling
  5. Swelling face
  6. Throat irritation
1 - 6 months:
  1. Anaemia (lack of blood)
  2. Renal cyst (kidney cyst)
  3. Nausea (feeling of having an urge to vomit)
  4. Abnormal behavior
  5. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  6. Nosebleed (bleeding from nose)
  7. Aggression
  8. Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
  9. Poor quality sleep
  10. Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
6 - 12 months:
  1. Dizziness
  2. Bone disorder
  3. Compression fracture (fracture due to pressure caused by injury)
  4. Muscle swelling
  5. Prostate cancer metastatic
  6. Skin swelling
  7. Osteonecrosis of jaw (death of bone of jaw)
  8. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  9. Constipation
  10. Haematochezia (passage of stools containing blood)
1 - 2 years:
  1. Chronic kidney disease
  2. Sleep apnea syndrome
  3. Asthma
  4. Spinal column stenosis (narrowing of spinal column)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Nausea (feeling of having an urge to vomit)
  7. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
  8. Abdominal pain
  9. Weight decreased
  10. Stress and anxiety
2 - 5 years:
  1. Depression
  2. Obstructive airways disorder (a progressive disease that makes it hard to breathe)
  3. Fever
  4. Suicidal ideation
  5. Productive cough
  6. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
  7. Inflammation
  8. Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
  9. Completed suicide (act of taking one's own life)
  10. Neck pain
5 - 10 years:
  1. Nightmares (unpleasant dreams)
  2. Drug ineffective
  3. Insomnia (sleeplessness)
  4. Fatigue (feeling of tiredness)
  5. Chronic kidney disease
  6. Acute kidney failure
  7. Cuts and puncture wounds
  8. Fever
  9. Limb injury
  10. Memory loss
10+ years:
  1. Pulmonary embolism (blockage of the main artery of the lung)
not specified:
  1. Fatigue (feeling of tiredness)
  2. Pneumonia
  3. Dizziness
  4. Drug ineffective
  5. Abdominal pain
  6. Breathing difficulty
  7. Depression
  8. Weakness
  9. Insomnia (sleeplessness)
  10. Nausea (feeling of having an urge to vomit)

Top conditions involved for these people *:

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 39 people, 12.83%
  2. Depression : 39 people, 12.83%
  3. High Blood Cholesterol : 35 people, 11.51%
  4. Stress And Anxiety : 26 people, 8.55%
  5. Diabetes : 24 people, 7.89%
  6. Sleep Disorder : 19 people, 6.25%
  7. Insomnia (sleeplessness): 17 people, 5.59%
  8. Muscle Relaxant Therapy : 17 people, 5.59%
  9. Bipolar Disorder (mood disorder): 16 people, 5.26%
  10. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 5.26%

Top co-used drugs for these people *:

  1. Nexium (41 people, 13.49%)
  2. Prilosec (39 people, 12.83%)
  3. Metformin (36 people, 11.84%)
  4. Lyrica (36 people, 11.84%)
  5. Protonix (31 people, 10.20%)
  6. Seroquel (31 people, 10.20%)
  7. Percocet (30 people, 9.87%)
  8. Cymbalta (27 people, 8.88%)
  9. Ambien (26 people, 8.55%)
  10. Vitamin D3 (26 people, 8.55%)

* Some reports may have incomplete information.

You are not alone:

What are the drugs?

What are the conditions?

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FDA reports used in this study

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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