A study for a 42 year old woman who takes Cymbalta, Sam-E, Topamax - from FDA reports


846 females aged 42 (±5) who take the same drugs are studied. This is a personalized study for a 42 year old female patient who has Depression, Headaches. The study is created by eHealthMe based on reports from FDA.

How to use this study: bring a copy to your health teams to ensure drug risks and benefits are fully discussed and understood.


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On Feb, 17, 2019

846 females aged 42 (±5) who take Cymbalta, Sam-E, Topamax are studied.


Number of reports submitted per year:

Cymbalta, Sam-E, Topamax for a 42-year old woman.

Information of the patient in this study:

  • Age: 42
  • Gender: female
  • Conditions: Depression, Headaches
  • Drugs taken:
    • Cymbalta (duloxetine hydrochloride)
    • Sam-E (same)
    • Topamax (topiramate)

eHealthMe real world results:

Most common drug interactions over time

< 1 month:
  1. Urticaria (rash of round, red welts on the skin that itch intensely)
  2. Angioedema (rapid swelling of the dermis)
  3. Suicidal ideation
  4. Panic disorder
  5. Alanine aminotransferase increased
  6. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  7. Dizziness
  8. Drug ineffective
  9. Feeling abnormal
  10. Spinal fusion surgery
1 - 6 months:
  1. Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat)
  2. Weight decreased
  3. Lipoma (a growth of fatty tissue that slowly develops just under your skin)
  4. Pain
  5. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Swallowing difficulty
  8. Feeling abnormal
  9. Apathy
  10. Muscle spasms (muscle contraction)
6 - 12 months:
  1. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  2. Heart palpitations (feelings or sensations that your heart is pounding or racing)
  3. Dizziness
  4. Nausea and vomiting
  5. Breathing difficulty
  6. Fall
  7. Vision blurred
  8. Feeling abnormal
  9. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
  10. Feeling cold
1 - 2 years:
  1. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  2. Drug ineffective
  3. Cerebral infarction (less blood supply to brain resulting tissue damage)
  4. Dizziness
  5. Pain
  6. Emotional distress
  7. Weight increased
  8. Memory loss
  9. Injury
  10. Cleft palate (birth defect (congenital) of the upper part of the mouth)
2 - 5 years:
  1. Anaemia (lack of blood)
  2. Intervertebral disc protrusion (spinal disc protrusion)
  3. Nausea and vomiting
  4. Kidney stones
  5. Confusional state
  6. Hyperthyroidism (over activity of the thyroid gland)
  7. Feeling abnormal
  8. Incontinence (lack of moderation or self-control)
  9. Irritability
  10. Gastrointestinal disorder (functional problems of gastrointestinal tract)
5 - 10 years:
  1. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  2. Abdominal pain
  3. Abdominal discomfort
  4. Nausea and vomiting
  5. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  6. Fatigue (feeling of tiredness)
  7. Weight decreased
  8. Nausea (feeling of having an urge to vomit)
  9. Insomnia (sleeplessness)
  10. Suicidal ideation
10+ years:
  1. Stem cell transplant
  2. Peripheral swelling
  3. Joint swelling
  4. Fatigue (feeling of tiredness)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Swelling face
  7. Muscle spasms (muscle contraction)
  8. Tooth extraction
  9. Drowsiness
  10. Pain
not specified:
  1. Pain
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Memory loss
  5. Diarrhea
  6. Drug ineffective
  7. Dizziness
  8. Nausea and vomiting
  9. Fall
  10. Weakness

Top conditions involved for these people *:

  1. Pain : 108 people, 12.77%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 104 people, 12.29%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 76 people, 8.98%
  4. Sleep Disorder : 54 people, 6.38%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 44 people, 5.20%
  6. Bipolar Disorder (mood disorder): 43 people, 5.08%
  7. High Blood Pressure : 40 people, 4.73%
  8. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 38 people, 4.49%
  9. Muscle Spasms (muscle contraction): 36 people, 4.26%
  10. Insomnia (sleeplessness): 32 people, 3.78%

Top co-used drugs for these people *:

  1. Lyrica (156 people, 18.44%)
  2. Xanax (98 people, 11.58%)
  3. Neurontin (95 people, 11.23%)
  4. Klonopin (89 people, 10.52%)
  5. Ambien (88 people, 10.40%)
  6. Synthroid (82 people, 9.69%)
  7. Xyrem (81 people, 9.57%)
  8. Seroquel (74 people, 8.75%)
  9. Lamictal (71 people, 8.39%)
  10. Zanaflex (69 people, 8.16%)

* Some reports may have incomplete information.

You are not alone:

What are the drugs?

What are the conditions?



Related studies:

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FDA reports used in this study


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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