Acetaminophen and codeine phosphate side effects - from FDA reports


In this review, we analyze Acetaminophen and codeine phosphate side effects by the time on the drug, gender and age of the people who have side effects while taking Acetaminophen and codeine phosphate. The review is based on 2,908 people who have side effects while taking the drug from FDA, and is updated regularly.

Acetaminophen And Codeine Phosphate

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. (latest outcomes from Acetaminophen and codeine phosphate 3,208 users)


On Jun, 05, 2018

2,908 people who take Acetaminophen And Codeine Phosphate are studied.


Number of reports submitted per year:

Acetaminophen and codeine phosphate side effects.

Most common side effects over time *:

< 1 month:
  • Vomiting
  • Acidosis (build-up of carbon dioxide in the blood)
  • Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
  • Furuncle (infection of the hair follicle)
  • Death
  • Dehydration (dryness resulting from the removal of water)
  • Dyspnoea (difficult or laboured respiration)
  • Lip swelling
  • Myalgia (muscle pain)
  • Osteonecrosis (death of bone)
1 - 6 months:
  • Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  • Mouth ulceration (mouth ulcers)
  • Arthralgia (joint pain)
  • Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  • Cytolytic hepatitis (dissolution or destruction of a liver cell)
  • Glomerular filtration rate decreased
  • Hyperkalaemia (damage to or disease of the kidney)
  • Muscular weakness (muscle weakness)
  • Toxic skin eruption (skin breakdown due to toxic substance)
  • Acute myocardial infarction (acute heart attack)
6 - 12 months:
  • Colitis ulcerative (inflammation of colon with ulcer)
  • Abdominal distension
  • Drug ineffective
  • Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
1 - 2 years:
  • Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
  • Hip dysplasia (abnormal formation of the hip socket)
  • Angioedema (rapid swelling of the dermis)
  • Calciphylaxis (is a syndrome with vascular calcium accumulation)
2 - 5 years:
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Cellulitis (infection under the skin)
  • Circulatory collapse
  • Hallucination, visual (seeing things that aren't there)
  • Tooth infection
5 - 10 years:
  • Pneumonia
  • Proteinuria (presence of protein in the urine)
not specified:
  • Completed suicide (act of taking one's own life)
  • Vomiting
  • Abdominal pain
  • Death
  • Overdose
  • Diarrhoea
  • Drug exposure during pregnancy
  • Dyspnoea (difficult or laboured respiration)
  • Anaphylactic reaction (serious allergic reaction)
  • Pyrexia (fever)

Most common side effects by gender *:

female:
  • Completed suicide (act of taking one's own life)
  • Vomiting
  • Anaphylactic reaction (serious allergic reaction)
  • Diarrhoea
  • Epistaxis (bleed from the nose)
  • Headache (pain in head)
  • Abdominal pain
  • Abdominal pain upper
  • Cardiac failure
  • Drug toxicity
male:
  • Vomiting
  • Psoriasis (immune-mediated disease that affects the skin)
  • Abdominal pain
  • Completed suicide (act of taking one's own life)
  • Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  • Dyspnoea (difficult or laboured respiration)
  • Tremor (trembling or shaking movements in one or more parts of your body)
  • Death
  • Erectile dysfunction
  • Weight increased

Most common side effects by age *:

0-1:
  • Drug exposure during pregnancy
  • Drug level above therapeutic
  • Insomnia (sleeplessness)
  • Maternal exposure during pregnancy (use of substance during pregnancy)
  • Respiratory distress (difficulty in breathing)
  • Therapeutic agent toxicity (poisoning by ability to cure substance)
2-9:
  • Acute hepatic failure
  • Vomiting
  • Agitation (state of anxiety or nervous excitement)
  • Coma (state of unconsciousness lasting more than six hours)
  • Death
  • Drug level increased
  • Hallucination, auditory (perceiving sounds without auditory stimulus)
  • Hepatic enzyme increased
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Presyncope
10-19:
  • Completed suicide (act of taking one's own life)
  • Intra-uterine death
  • Apnoea (suspension of external breathing)
  • Drug exposure during pregnancy
  • Multiple drug overdose intentional
  • Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
  • Respiratory depression (respiration has a rate below 12 breaths)
  • Tumour haemorrhage (bleeding from tumour)
  • Unresponsive to stimuli
  • Urticaria (rash of round, red welts on the skin that itch intensely)
20-29:
  • Overdose
  • Drug toxicity
  • Erectile dysfunction
  • Mouth cyst (a fluid filled sac in mouth)
  • Pregnancy
  • Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  • Completed suicide (act of taking one's own life)
  • Loss of libido (loss of sexual urge)
  • Accidental overdose
  • Aphthous stomatitis (mouth ulcer)
30-39:
  • Maternal exposure during pregnancy (use of substance during pregnancy)
  • Intra-uterine death
  • Abortion spontaneous (naturally occurring miscarriage)
  • Completed suicide (act of taking one's own life)
  • Loss of consciousness
  • Nausea (feeling of having an urge to vomit)
  • Acidosis (build-up of carbon dioxide in the blood)
  • Alopecia (absence of hair from areas of the body)
  • Dependence
  • Drug exposure during pregnancy
40-49:
  • Completed suicide (act of taking one's own life)
  • Neutropenia (an abnormally low number of neutrophils)
  • Pancreatitis (inflammation of pancreas)
  • Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
  • Drug abuse
  • Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
  • Anaphylactic reaction (serious allergic reaction)
  • Dependence
  • Erythrodermic psoriasis (generalized redness of the skin)
  • Abdominal wall abscess (abdominal wall infection)
50-59:
  • Completed suicide (act of taking one's own life)
  • Abdominal pain
  • Anaphylactic reaction (serious allergic reaction)
  • Erectile dysfunction
  • Headache (pain in head)
  • Dyspnoea (difficult or laboured respiration)
  • Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  • Vena cava thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart)
  • Weight increased
  • Alopecia (absence of hair from areas of the body)
60+:
  • Completed suicide (act of taking one's own life)
  • Vomiting
  • Diarrhoea
  • Arthralgia (joint pain)
  • Cardiac failure
  • Death
  • Epistaxis (bleed from the nose)
  • Weight decreased
  • Abdominal pain
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

* Approximation only. Some reports may have incomplete information.

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