Artesunate side effects by duration, gender and age - a phase IV clinical study of FDA data

< 1 month:

1. Coombs test positive
2. Death
3. Disseminated intravascular coagulation (systemic activation of blood coagulation)
4. Encephalopathy (functioning of the brain is affected by some agent or condition)
5. Intentional self-injury
6. Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
7. Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
8. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
9. Haemolytic anaemia (anaemia due to haemolysis)
10. Anaemia (lack of blood)

1 - 6 months:

1. Alanine aminotransferase increased
2. Asthenia (weakness)
3. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)

6 - 12 months:

n/a

1 - 2 years:

n/a

2 - 5 years:

n/a

5 - 10 years:

n/a

10+ years:

n/a

not specified:

1. Drug ineffective
2. Abdominal discomfort
3. Alanine aminotransferase increased
4. Cytomegalovirus infection
5. Encephalitis (inflammation of the brain)
6. Febrile neutropenia (fever with reduced white blood cells)
7. Haemolytic anaemia (anaemia due to haemolysis)
8. Hyperthermia (body temperature greatly above normal)
9. Malaria (a parasitic disease due to mosquito bite)
10. Acute respiratory distress syndrome

female:

1. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
2. Alanine aminotransferase increased
3. Asthenia (weakness)
4. Drug ineffective
5. Haemolytic anaemia (anaemia due to haemolysis)
6. Agitation (state of anxiety or nervous excitement)
7. Anaemia (lack of blood)
8. Apgar score low
9. Coombs test positive
10. Cytomegalovirus infection

male:

1. Drug ineffective
2. Haemolytic anaemia (anaemia due to haemolysis)
3. Encephalopathy (functioning of the brain is affected by some agent or condition)
4. Hyperthermia (body temperature greatly above normal)
5. Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
6. Myelosuppression (a decrease in the production of blood cells)
7. Renal failure (kidney dysfunction)
8. Staphylococcal infection (an infection with staphylococcus bacteria)
9. Encephalitis (inflammation of the brain)
10. Febrile neutropenia (fever with reduced white blood cells)

0-1:

1. Acute respiratory distress syndrome
2. Hyperthermia (body temperature greatly above normal)

2-9:

1. Drug ineffective
2. Disease progression
3. Haemolytic anaemia (anaemia due to haemolysis)
4. Hyperthermia (body temperature greatly above normal)
5. Myelosuppression (a decrease in the production of blood cells)

10-19:

1. Encephalitis (inflammation of the brain)
2. Febrile neutropenia (fever with reduced white blood cells)
3. Disseminated intravascular coagulation (systemic activation of blood coagulation)
4. Haemolytic anaemia (anaemia due to haemolysis)
5. Intentional self-injury
6. Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
7. Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)
8. Staphylococcal infection (an infection with staphylococcus bacteria)

20-29:

1. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
2. Agitation (state of anxiety or nervous excitement)
3. Drug ineffective
4. Haemolytic anaemia (anaemia due to haemolysis)
5. Malaria (a parasitic disease due to mosquito bite)

30-39:

1. Drug ineffective
2. Coombs positive haemolytic anaemia
3. Coombs test positive
4. Cytomegalovirus infection
5. Foetal death (death of foetus)
6. Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

1. Drug ineffective
2. Haemolytic anaemia (anaemia due to haemolysis)
3. Encephalopathy (functioning of the brain is affected by some agent or condition)

50-59:

1. Anuria (failure of the kidneys to produce urine)
2. Haemolytic anaemia (anaemia due to haemolysis)
3. Renal failure (kidney dysfunction)

60+:

1. Alanine aminotransferase increased
2. Asthenia (weakness)
3. Acidosis (build-up of carbon dioxide in the blood)
4. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
5. Anaemia (lack of blood)
6. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)