Ibuprofen side effects - from FDA reports


In this review, we analyze Ibuprofen side effects by the time on the drug, gender and age of the people who have side effects while taking Ibuprofen. The review is based on 125,169 people who have side effects while taking the drug from FDA, and is updated regularly.

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Ibuprofen

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from Ibuprofen 130,381 users)


On Mar, 17, 2019

125,169 people who take Ibuprofen are studied.


Number of reports submitted per year:

Ibuprofen side effects.

Most common side effects over time *:

< 1 month:
  • Vomiting
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Renal failure acute (rapid kidney dysfunction)
  • Suicide attempt
  • Rash
  • Melaena (the passage of black, tarry stools)
  • Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Somnolence (a state of near-sleep, a strong desire for sleep)
  • Thrombocytopenia (decrease of platelets in blood)
1 - 6 months:
  • Weight decreased
  • Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  • Gastric haemorrhage (bleeding stomach)
  • Hyperkalaemia (damage to or disease of the kidney)
  • Lethargy (tiredness)
  • Haematemesis (vomiting of blood)
  • Melaena (the passage of black, tarry stools)
  • Tremor (trembling or shaking movements in one or more parts of your body)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Pancreatitis acute (sudden inflammation of pancreas)
6 - 12 months:
  • Renal failure acute (rapid kidney dysfunction)
  • Death
  • Melaena (the passage of black, tarry stools)
  • Renal failure (kidney dysfunction)
  • Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital))
  • Drug ineffective
  • Wound
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Renal impairment (severely reduced kidney function)
  • Vomiting
1 - 2 years:
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Haematemesis (vomiting of blood)
  • Melaena (the passage of black, tarry stools)
  • Renal failure acute (rapid kidney dysfunction)
  • Weight decreased
  • Rectal haemorrhage (bleeding from anus)
  • Loose tooth
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Skin toxicity (skin damage due to toxin/poison)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
2 - 5 years:
  • Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  • Renal failure (kidney dysfunction)
  • Vomiting
  • Liver function test abnormal
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
  • Chronic kidney disease
  • Depression
  • Drug ineffective
  • Thrombosis (formation of a blood clot inside a blood vessel)
5 - 10 years:
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Renal impairment (severely reduced kidney function)
  • Anxiety
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Weight decreased
  • Chronic kidney disease
  • Electrocardiogram qt prolonged
  • Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  • Abortion spontaneous (naturally occurring miscarriage)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
10+ years:
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Vomiting
  • Weight decreased
  • Blood cholesterol increased
  • Blood pressure decreased
  • Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  • Dyspnoea (difficult or laboured respiration)
  • Emotional distress
  • Gallbladder disorder
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
not specified:
  • Vomiting
  • Drug ineffective
  • Weight decreased
  • Drug hypersensitivity
  • Nausea (feeling of having an urge to vomit)
  • Weight increased
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Completed suicide (act of taking one's own life)
  • Death

Most common side effects by gender *:

female:
  • Vomiting
  • Drug ineffective
  • Weight decreased
  • Drug hypersensitivity
  • Nausea (feeling of having an urge to vomit)
  • Weight increased
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Rash
  • Urinary tract infection
male:
  • Vomiting
  • Weight decreased
  • Rash
  • Weight increased
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Suicide attempt
  • Somnolence (a state of near-sleep, a strong desire for sleep)
  • Syncope (loss of consciousness with an inability to maintain postural tone)
  • Thrombocytopenia (decrease of platelets in blood)
  • Tremor (trembling or shaking movements in one or more parts of your body)

Most common side effects by age *:

0-1:
  • Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
  • Vomiting
  • Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)
  • Neonatal hypoxia (lack of oxygen in neonate)
  • Premature baby
  • Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital))
  • Intestinal perforation (complete penetration of the wall of the intestine)
  • Drug ineffective
  • Wheezing (a high-pitched whistling sound made while you breath)
  • Rash
2-9:
  • Vomiting
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  • Pyrexia (fever)
  • Angioedema (rapid swelling of the dermis)
  • Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
  • Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  • Drug hypersensitivity
  • Renal failure acute (rapid kidney dysfunction)
  • Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
10-19:
  • Vomiting
  • Suicide attempt
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Completed suicide (act of taking one's own life)
  • Angioedema (rapid swelling of the dermis)
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Nausea (feeling of having an urge to vomit)
  • Weight decreased
  • Drug hypersensitivity
  • Abdominal pain
20-29:
  • Tremor (trembling or shaking movements in one or more parts of your body)
  • Overdose
  • Vomiting
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Uterine perforation (accidental puncture of the uterus)
  • Completed suicide (act of taking one's own life)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Suicide attempt
  • Nausea (feeling of having an urge to vomit)
30-39:
  • Vomiting
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Weight increased
  • Nausea (feeling of having an urge to vomit)
  • Completed suicide (act of taking one's own life)
  • Weight decreased
  • Pyrexia (fever)
  • Drug ineffective
40-49:
  • Vomiting
  • Weight increased
  • Weight decreased
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Completed suicide (act of taking one's own life)
  • Nausea (feeling of having an urge to vomit)
  • Drug ineffective
  • Drug hypersensitivity
  • Somnolence (a state of near-sleep, a strong desire for sleep)
  • Death
50-59:
  • Vomiting
  • Weight decreased
  • Drug ineffective
  • Drug hypersensitivity
  • Nausea (feeling of having an urge to vomit)
  • Weight increased
  • Death
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Rash
  • Completed suicide (act of taking one's own life)
60+:
  • Vomiting
  • Weight decreased
  • Drug ineffective
  • Drug hypersensitivity
  • Renal failure acute (rapid kidney dysfunction)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Nausea (feeling of having an urge to vomit)
  • Urinary tract infection
  • Weight increased
  • Death

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study

You are not alone:

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On eHealthMe, Ibuprofen (ibuprofen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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