Ibuprofen side effects - from FDA reports


In this review, we analyze Ibuprofen side effects by the time on the drug, gender and age of the people who have side effects while taking Ibuprofen. The review is based on 120,126 people who have side effects while taking the drug from FDA, and is updated regularly.

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Ibuprofen

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from Ibuprofen 125,338 users)


On Sep, 03, 2018

120,126 people who take Ibuprofen are studied.


Number of reports submitted per year:

Ibuprofen side effects.

Most common side effects over time *:

< 1 month:
  • Vomiting
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Renal failure acute (rapid kidney dysfunction)
  • Suicide attempt
  • Rash
  • Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Melaena (the passage of black, tarry stools)
  • Somnolence (a state of near-sleep, a strong desire for sleep)
  • Thrombocytopenia (decrease of platelets in blood)
1 - 6 months:
  • Renal failure acute (rapid kidney dysfunction)
  • Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
  • Vomiting
  • Drug ineffective
  • Renal impairment (severely reduced kidney function)
  • Anaemia (lack of blood)
  • Weight decreased
  • Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  • Gastric haemorrhage (bleeding stomach)
  • Hyperkalaemia (damage to or disease of the kidney)
6 - 12 months:
  • Renal failure acute (rapid kidney dysfunction)
  • Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital))
  • Death
  • Drug ineffective
  • Melaena (the passage of black, tarry stools)
  • Renal failure (kidney dysfunction)
  • Wound
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Renal impairment (severely reduced kidney function)
  • Vomiting
1 - 2 years:
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Haematemesis (vomiting of blood)
  • Melaena (the passage of black, tarry stools)
  • Renal failure acute (rapid kidney dysfunction)
  • Weight decreased
  • Loose tooth
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Death
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
2 - 5 years:
  • Vomiting
  • Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  • Liver function test abnormal
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Renal failure (kidney dysfunction)
  • Drug ineffective
  • Thrombosis (formation of a blood clot inside a blood vessel)
  • Colonic polyp (extra part of colon tissue grow in intestine)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Depression
5 - 10 years:
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Renal impairment (severely reduced kidney function)
  • Anxiety
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Weight decreased
  • Electrocardiogram qt prolonged
  • Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
  • Abortion spontaneous (naturally occurring miscarriage)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • General physical health deterioration (weak health status)
10+ years:
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Vomiting
  • Perforated ulcer
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Liver disorder (liver diseases)
  • Chronic kidney disease
  • Coarctation of the aorta (narrowing of the part of aorta)
  • Injury
  • Renal failure (kidney dysfunction)
  • Syncope (loss of consciousness with an inability to maintain postural tone)
not specified:
  • Vomiting
  • Drug ineffective
  • Weight decreased
  • Drug hypersensitivity
  • Nausea (feeling of having an urge to vomit)
  • Weight increased
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Completed suicide (act of taking one's own life)
  • Death

Most common side effects by gender *:

female:
  • Vomiting
  • Drug ineffective
  • Weight decreased
  • Drug hypersensitivity
  • Nausea (feeling of having an urge to vomit)
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Weight increased
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Rash
  • Urinary tract infection
male:
  • Vomiting
  • Weight decreased
  • Drug ineffective
  • Death
  • Renal failure acute (rapid kidney dysfunction)
  • Completed suicide (act of taking one's own life)
  • Pyrexia (fever)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Nausea (feeling of having an urge to vomit)
  • Drug hypersensitivity

Most common side effects by age *:

0-1:
  • Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
  • Vomiting
  • Premature baby
  • Neonatal hypoxia (lack of oxygen in neonate)
  • Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital))
  • Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)
  • Intestinal perforation (complete penetration of the wall of the intestine)
  • Drug ineffective
  • Wheezing (a high-pitched whistling sound made while you breath)
  • Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
2-9:
  • Vomiting
  • Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Pyrexia (fever)
  • Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
  • Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  • Renal failure acute (rapid kidney dysfunction)
  • Angioedema (rapid swelling of the dermis)
  • Drug hypersensitivity
  • Renal tubular necrosis (death of kidney tubules)
10-19:
  • Vomiting
  • Suicide attempt
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Completed suicide (act of taking one's own life)
  • Angioedema (rapid swelling of the dermis)
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Nausea (feeling of having an urge to vomit)
  • Weight decreased
  • Abdominal pain
  • Renal failure acute (rapid kidney dysfunction)
20-29:
  • Vomiting
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Uterine perforation (accidental puncture of the uterus)
  • Completed suicide (act of taking one's own life)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Suicide attempt
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Nausea (feeling of having an urge to vomit)
  • Cholecystitis chronic (long lasting infection of gallbladder)
  • Weight decreased
30-39:
  • Vomiting
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Weight increased
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Nausea (feeling of having an urge to vomit)
  • Completed suicide (act of taking one's own life)
  • Weight decreased
  • Pyrexia (fever)
  • Drug ineffective
40-49:
  • Vomiting
  • Weight increased
  • Weight decreased
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Completed suicide (act of taking one's own life)
  • Nausea (feeling of having an urge to vomit)
  • Drug ineffective
  • Drug hypersensitivity
  • Somnolence (a state of near-sleep, a strong desire for sleep)
  • Death
50-59:
  • Vomiting
  • Weight decreased
  • Drug ineffective
  • Drug hypersensitivity
  • Nausea (feeling of having an urge to vomit)
  • Weight increased
  • Death
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Rash
  • Completed suicide (act of taking one's own life)
60+:
  • Vomiting
  • Weight decreased
  • Drug ineffective
  • Renal failure acute (rapid kidney dysfunction)
  • Drug hypersensitivity
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Nausea (feeling of having an urge to vomit)
  • Death
  • Urinary tract infection
  • Weight increased

* Approximation only. Some reports may have incomplete information.

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Want to find out more about the FDA reports used in the study? You can request them from FDA.

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On eHealthMe, Ibuprofen (ibuprofen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

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