Isoniazid side effects - from FDA reports


In this review, we analyze Isoniazid side effects by the time on the drug, gender and age of the people who have side effects while taking Isoniazid. The review is based on 10,753 people who have side effects while taking the drug from FDA, and is updated regularly.

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Isoniazid

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from Isoniazid 11,054 users)


On Aug, 19, 2018

10,753 people who take Isoniazid are studied.


Number of reports submitted per year:

Isoniazid side effects.

Most common side effects over time *:

< 1 month:
  • Pyrexia (fever)
  • Renal failure acute (rapid kidney dysfunction)
  • Vomiting
  • Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
  • Hepatic function abnormal
  • Interstitial lung disease
  • Rash
  • Weight decreased
  • Hepatitis (inflammation of the liver)
  • Thrombocytopenia (decrease of platelets in blood)
1 - 6 months:
  • Vomiting
  • Hepatitis (inflammation of the liver)
  • Interstitial lung disease
  • Pneumonia
  • Liver disorder (liver diseases)
  • Hepatic function abnormal
  • Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  • Death
  • Weight decreased
  • Arthralgia (joint pain)
6 - 12 months:
  • Renal failure (kidney dysfunction)
  • Vomiting
  • Death
  • Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
  • Neutropenia (an abnormally low number of neutrophils)
  • Pyrexia (fever)
  • Cerebral haemorrhage (bleeding within the brain)
  • Interstitial lung disease
  • Pulmonary mass
  • Visual acuity reduced (reduced clearness of vision)
1 - 2 years:
  • Neoplasm malignant (cancer tumour)
  • Renal failure (kidney dysfunction)
  • Gastrointestinal necrosis (destruction of gastrointestinal organ)
  • Haemorrhage subcutaneous (bleeding from skin)
  • Cataract (clouding of the lens inside the eye)
  • Large cell carcinoma of the respiratory tract stage unspecified (lung cancer of large cells unspecified)
  • Neck mass (mass in neck)
  • Arthralgia (joint pain)
  • Cerebral infarction (less blood supply to brain resulting tissue damage)
  • Herpes zoster
2 - 5 years:
  • Shock haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding)
  • Angioedema (rapid swelling of the dermis)
  • Arthralgia (joint pain)
  • Cardiac failure
  • Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  • Colitis ulcerative (inflammation of colon with ulcer)
  • Cytomegalovirus gastroenteritis (virus infection of stomach and intestine)
  • Erythroblast count decreased
  • Thyroid cancer
  • Cerebral haemorrhage (bleeding within the brain)
5 - 10 years:
  • Anaemia (lack of blood)
  • Malignant ascites (a condition in which a person with cancer has an accumulation of fluid in the abdomen)
  • Nausea (feeling of having an urge to vomit)
  • Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
10+ years:
  • Respiratory failure (inadequate gas exchange by the respiratory system)
  • Drug resistance (reduction in effectiveness of a drug)
  • Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  • Weight decreased
not specified:
  • Vomiting
  • Pyrexia (fever)
  • Weight decreased
  • Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  • Thrombocytopenia (decrease of platelets in blood)
  • White blood cell count decreased
  • Paradoxical drug reaction
  • Pneumonia
  • Rash
  • Liver function test abnormal

Most common side effects by gender *:

female:
  • Vomiting
  • Pyrexia (fever)
  • Weight decreased
  • White blood cell count decreased
  • Rash
  • Thrombocytopenia (decrease of platelets in blood)
  • Pneumonia
  • Interstitial lung disease
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • White blood cell count increased
male:
  • Vomiting
  • Pyrexia (fever)
  • Weight decreased
  • Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  • Renal failure acute (rapid kidney dysfunction)
  • Thrombocytopenia (decrease of platelets in blood)
  • Liver function test abnormal
  • Death
  • Pneumonia
  • White blood cell count decreased

Most common side effects by age *:

0-1:
  • Vomiting
  • Trisomy 21 (a chromosomal disorder that results in the presence of an additional third chromosome 21)
  • Drug resistance (reduction in effectiveness of a drug)
  • Premature baby
  • Respiratory failure (inadequate gas exchange by the respiratory system)
  • Acute hepatic failure
  • Death
  • Hepatic failure (liver failure)
  • Pyrexia (fever)
  • Bovine tuberculosis (tuberculosis caused by mycobacterium bovis is a slow-growing (16 to 20 hour generation time), aerobic bacterium)
2-9:
  • Vomiting
  • Paradoxical drug reaction
  • Tuberculoma of central nervous system (a tumour-like mass that is not a cancer in brain, a complication of tuberculosis)
  • Drug resistance (reduction in effectiveness of a drug)
  • Acute hepatic failure
  • Ocular icterus (presence of jaundice seen in the sclera of the eye)
  • Optic neuritis (optic nerve inflammation)
  • Transaminases increased
  • Alanine aminotransferase increased
  • Blood lactate dehydrogenase abnormal
10-19:
  • Vomiting
  • Acute hepatic failure
  • Thrombocytopenia (decrease of platelets in blood)
  • Tuberculoma of central nervous system (a tumour-like mass that is not a cancer in brain, a complication of tuberculosis)
  • Weight decreased
  • Hepatotoxicity (chemical-driven liver damage)
  • Paradoxical drug reaction
  • Pyrexia (fever)
  • Transaminases increased
  • Abdominal pain
20-29:
  • Vomiting
  • Pyrexia (fever)
  • Weight decreased
  • Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  • Hepatotoxicity (chemical-driven liver damage)
  • Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  • Hepatitis (inflammation of the liver)
  • Abdominal pain upper
  • Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
  • Nausea (feeling of having an urge to vomit)
30-39:
  • Vomiting
  • Pyrexia (fever)
  • White blood cell count decreased
  • Spermatozoa progressive motility decreased
  • Hepatitis (inflammation of the liver)
  • Spermatozoa progressive motility abnormal
  • Hepatitis toxic
  • Hepatotoxicity (chemical-driven liver damage)
  • Thrombocytopenia (decrease of platelets in blood)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
40-49:
  • Vomiting
  • Pyrexia (fever)
  • Death
  • Thrombocytopenia (decrease of platelets in blood)
  • Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  • Paradoxical drug reaction
  • Transaminases increased
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Weight decreased
  • Headache (pain in head)
50-59:
  • Vomiting
  • Weight decreased
  • Pyrexia (fever)
  • Liver function test abnormal
  • White blood cell count decreased
  • Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  • Renal failure acute (rapid kidney dysfunction)
  • Rash
  • Skin disorder (skin disease)
  • Nausea (feeling of having an urge to vomit)
60+:
  • Vomiting
  • Interstitial lung disease
  • Pneumonia
  • Pyrexia (fever)
  • Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  • White blood cell count decreased
  • Weight decreased
  • Respiratory failure (inadequate gas exchange by the respiratory system)
  • Skin disorder (skin disease)
  • Thrombocytopenia (decrease of platelets in blood)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Want to find out more about the FDA reports used in the study? You can request them from FDA.

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On eHealthMe, Isoniazid (isoniazid) is often used to treat tuberculosis. Find out below the conditions the drugs are used for and how effective they are.

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