Lupron side effects - from FDA reports


In this review, we analyze Lupron side effects by the time on the drug, gender and age of the people who have side effects while taking Lupron. The review is based on 23,900 people who have side effects while taking the drug from FDA, and is updated regularly.


Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA since 1977. Our original studies have been referenced on 400+ peer-reviewed medical publications, including: The Lancet, and Mayo Clinic Proceedings.


Lupron

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. (latest outcomes from Lupron 24,385 users)


On Apr, 24, 2018

23,900 people who take Lupron are studied.


Number of reports submitted per year:

Lupron side effects.

Most common side effects over time *:

< 1 month:
  • Weight increased
  • Vaginal haemorrhage (vaginal bleeding)
  • Hot flush (sudden feelings of heat)
  • Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
  • Pelvic pain
  • Vomiting
  • Death
  • Pain
  • Weight decreased
  • Mood swings (an extreme or rapid change in mood)
1 - 6 months:
  • Weight increased
  • Vaginal haemorrhage (vaginal bleeding)
  • Pelvic pain
  • Hot flush (sudden feelings of heat)
  • Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
  • Pain
  • Drug ineffective
  • Vomiting
  • Weight decreased
  • Headache (pain in head)
6 - 12 months:
  • Death
  • Weight increased
  • Hot flush (sudden feelings of heat)
  • Weight decreased
  • Pelvic pain
  • Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
  • Drug ineffective
  • Vaginal haemorrhage (vaginal bleeding)
  • Pain
  • Renal failure (kidney dysfunction)
1 - 2 years:
  • Death
  • Hot flush (sudden feelings of heat)
  • Prostatic specific antigen increased
  • Vomiting
  • Pelvic pain
  • Prostate cancer metastatic
  • Weight increased
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Pain
  • Pneumonia
2 - 5 years:
  • Death
  • Prostate cancer metastatic
  • Prostatic specific antigen increased
  • Weight decreased
  • Pain
  • Vomiting
  • Hot flush (sudden feelings of heat)
  • Neoplasm malignant (cancer tumour)
  • Weight increased
  • Fall
5 - 10 years:
  • Death
  • Fall
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Weight decreased
  • Hot flush (sudden feelings of heat)
  • Prostate cancer metastatic
  • Vomiting
  • General physical health deterioration (weak health status)
  • Injection site discomfort
  • Neoplasm malignant (cancer tumour)
10+ years:
  • Death
  • Weight decreased
  • Prostate cancer metastatic
  • Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
  • Abortion spontaneous (naturally occurring miscarriage)
  • Anaemia (lack of blood)
  • Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
  • Back pain
  • Blood testosterone decreased
  • Cardiac failure congestive
not specified:
  • Hot flush (sudden feelings of heat)
  • Vaginal haemorrhage (vaginal bleeding)
  • Weight increased
  • Weight decreased
  • Headache (pain in head)
  • Death
  • Pain
  • Vomiting
  • Pelvic pain
  • Nausea (feeling of having an urge to vomit)

Most common side effects by gender *:

female:
  • Vaginal haemorrhage (vaginal bleeding)
  • Hot flush (sudden feelings of heat)
  • Weight increased
  • Pelvic pain
  • Headache (pain in head)
  • Pain
  • Vomiting
  • Weight decreased
  • Nausea (feeling of having an urge to vomit)
  • Drug ineffective
male:
  • Death
  • Weight decreased
  • Prostatic specific antigen increased
  • Hot flush (sudden feelings of heat)
  • Vomiting
  • Prostate cancer metastatic
  • Malignant neoplasm progression (cancer tumour came back)
  • Fatigue (feeling of tiredness)
  • Weight increased
  • Pain

Most common side effects by age *:

0-1:
  • Injection site pain
  • Liver function test abnormal
  • Maternal drugs affecting foetus (chemical affecting the baby before birth taken by mother)
  • Tachypnoea (condition of rapid breathing over 20 per minute)
  • Umbilical cord vascular disorder
  • Febrile neutropenia (fever with reduced white blood cells)
  • Heart rate decreased
  • Hepatomegaly (abnormal enlargement of the liver)
  • Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
  • Neonatal aspiration (aspiration by neonate)
2-9:
  • Injection site pain
  • Injection site swelling
  • Injection site abscess
  • Weight increased
  • Pyrexia (fever)
  • Vomiting
  • Drug ineffective
  • Headache (pain in head)
  • Mood swings (an extreme or rapid change in mood)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
10-19:
  • Injection site pain
  • Vaginal haemorrhage (vaginal bleeding)
  • Vomiting
  • Weight decreased
  • Hot flush (sudden feelings of heat)
  • Pain
  • Depression
  • Pelvic pain
  • Weight increased
  • Suicidal ideation
20-29:
  • Vaginal haemorrhage (vaginal bleeding)
  • Pelvic pain
  • Weight increased
  • Hot flush (sudden feelings of heat)
  • Vomiting
  • Pain
  • Nausea (feeling of having an urge to vomit)
  • Weight decreased
  • Abdominal pain
  • Mood swings (an extreme or rapid change in mood)
30-39:
  • Vaginal haemorrhage (vaginal bleeding)
  • Weight increased
  • Hot flush (sudden feelings of heat)
  • Pelvic pain
  • Vomiting
  • Weight decreased
  • Nausea (feeling of having an urge to vomit)
  • Headache (pain in head)
  • Pain
  • Metrorrhagia (uterine bleeding at irregular intervals)
40-49:
  • Vaginal haemorrhage (vaginal bleeding)
  • Weight increased
  • Hot flush (sudden feelings of heat)
  • Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  • Pain
  • Pelvic pain
  • Headache (pain in head)
  • Vomiting
  • Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
  • Weight decreased
50-59:
  • Vaginal haemorrhage (vaginal bleeding)
  • Hot flush (sudden feelings of heat)
  • Weight increased
  • Weight decreased
  • Drug ineffective
  • Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  • Death
  • Headache (pain in head)
  • Pelvic pain
  • Pain
60+:
  • Death
  • Weight decreased
  • Prostatic specific antigen increased
  • Vomiting
  • Hot flush (sudden feelings of heat)
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Fatigue (feeling of tiredness)
  • Malignant neoplasm progression (cancer tumour came back)
  • Prostate cancer metastatic
  • Pyrexia (fever)

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Subscribe to the study: get notified of updates to the study.

Do you have side effects when taking Lupron? Share you experience to help people like you.

Want to find out more about the FDA reports used in the study? You can request them from FDA.

Expand the study to include reports from both FDA and eHealthMe

Lupron side effects from FDA and eHealthMe reports

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All Lupron side effects from A to Z

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On eHealthMe, Lupron (leuprolide acetate) is often used to treat endometriosis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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