Metformin hydrochloride side effects - from FDA reports


In this review, we analyze Metformin hydrochloride side effects by the time on the drug, gender and age of the people who have side effects while taking Metformin hydrochloride. The review is based on 21,816 people who have side effects while taking the drug from FDA, and is updated regularly.

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Metformin Hydrochloride

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin hydrochloride 25,529 users)


On Feb, 19, 2019

21,816 people who take Metformin Hydrochloride are studied.


Number of reports submitted per year:

Metformin hydrochloride side effects.

Most common side effects over time *:

< 1 month:
  • Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Vomiting
  • Diarrhoea
  • Nausea (feeling of having an urge to vomit)
  • Renal failure acute (rapid kidney dysfunction)
  • Intentional self-injury
  • Pruritus (severe itching of the skin)
  • Pyrexia (fever)
  • Somnolence (a state of near-sleep, a strong desire for sleep)
1 - 6 months:
  • Premature delivery
  • Premature baby
  • Vomiting
  • Pancreatitis acute (sudden inflammation of pancreas)
  • Tremor (trembling or shaking movements in one or more parts of your body)
  • Weight decreased
  • Pemphigoid (tense blisters on the skin)
  • Renal impairment (severely reduced kidney function)
  • Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  • Hepatic function abnormal
6 - 12 months:
  • Lactic acidosis (low ph in body tissues)
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Nausea (feeling of having an urge to vomit)
  • Presyncope
  • Renal failure acute (rapid kidney dysfunction)
  • Vomiting
  • Pain in extremity
  • Vitamin b12 deficiency
  • Weight decreased
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
1 - 2 years:
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)
  • Renal failure (kidney dysfunction)
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Renal failure acute (rapid kidney dysfunction)
  • Vomiting
  • Weight decreased
  • Death
  • Lactic acidosis (low ph in body tissues)
  • Drug ineffective
2 - 5 years:
  • Vomiting
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Lactic acidosis (low ph in body tissues)
  • Cardiac failure
  • Renal failure acute (rapid kidney dysfunction)
  • Nephropathy (damage to or disease of a kidney)
  • Facial palsy (paralysis of face nerve)
  • Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)
  • Tachypnoea (condition of rapid breathing over 20 per minute)
5 - 10 years:
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Vomiting
  • Weight decreased
  • Decreased appetite
  • Lactic acidosis (low ph in body tissues)
  • Renal failure acute (rapid kidney dysfunction)
  • Diarrhoea
  • Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
  • Liver disorder (liver diseases)
10+ years:
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Multi-organ failure (multisystem organ failure)
  • Oedema peripheral (superficial swelling)
  • Renal disorder (kidney disease)
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Sinusitis (inflammation of sinus)
  • Syncope (loss of consciousness with an inability to maintain postural tone)
  • Vitreous haemorrhage (intraocular (inside the eye) bleeding)
  • Cardiac failure
not specified:
  • Vomiting
  • Lactic acidosis (low ph in body tissues)
  • Weight decreased
  • Blood glucose increased
  • Renal failure acute (rapid kidney dysfunction)
  • Drug ineffective
  • Completed suicide (act of taking one's own life)
  • Nausea (feeling of having an urge to vomit)
  • Diarrhoea
  • Hypoglycaemia (deficiency of glucose in the bloodstream)

Most common side effects by gender *:

female:
  • Vomiting
  • Lactic acidosis (low ph in body tissues)
  • Weight decreased
  • Nausea (feeling of having an urge to vomit)
  • Renal failure acute (rapid kidney dysfunction)
  • Diarrhoea
  • Weight increased
  • Drug ineffective
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Blood glucose increased
male:
  • Vomiting
  • Lactic acidosis (low ph in body tissues)
  • Renal failure (kidney dysfunction)
  • Death
  • Diarrhoea
  • Nausea (feeling of having an urge to vomit)
  • Weight increased
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Pancreatitis (inflammation of pancreas)
  • Pancreatitis acute (sudden inflammation of pancreas)

Most common side effects by age *:

0-1:
  • Premature baby
  • Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
  • Accidental poisoning
  • Hypoglycaemia neonatal (deficiency of glucose in the bloodstream in neonatal)
  • Large for dates baby (a baby looks older than gestational period by weight and appearance)
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Osteogenesis imperfecta (a genetic disorder in which bones break easily)
  • Patent ductus arteriosus (condition in which the ductus arteriosus does not close)
  • Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
  • Seizure (abnormal excessive or synchronous neuronal activity in the brain)
2-9:
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • White blood cell count increased
  • Accidental overdose
  • Attention deficit/hyperactivity disorder
  • Hypertriglyceridaemia (excess of triglycerides in the blood)
  • Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
  • Pulmonary hypoplasia (incomplete development of the lungs)
  • Renal failure (kidney dysfunction)
10-19:
  • Vomiting
  • Suicide attempt
  • Completed suicide (act of taking one's own life)
  • Lactic acidosis (low ph in body tissues)
  • Pancreatitis acute (sudden inflammation of pancreas)
  • Intentional overdose
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Pancreatitis (inflammation of pancreas)
  • Tachypnoea (condition of rapid breathing over 20 per minute)
  • Type i hypersensitivity
20-29:
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Completed suicide (act of taking one's own life)
  • Vomiting
  • Suicide attempt
  • Overdose
  • Intentional overdose
  • Maternal exposure during pregnancy (use of substance during pregnancy)
  • Weight increased
  • Malaise (a feeling of general discomfort or uneasiness)
  • Nausea (feeling of having an urge to vomit)
30-39:
  • Completed suicide (act of taking one's own life)
  • Suicide attempt
  • Lactic acidosis (low ph in body tissues)
  • Vomiting
  • Weight decreased
  • Agitation (state of anxiety or nervous excitement)
  • Maternal exposure during pregnancy (use of substance during pregnancy)
  • Pancreatitis acute (sudden inflammation of pancreas)
  • Angina pectoris (chest pain due to ischemia of the heart muscle)
  • Headache (pain in head)
40-49:
  • Vomiting
  • Completed suicide (act of taking one's own life)
  • Weight decreased
  • Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  • Lactic acidosis (low ph in body tissues)
  • Vision blurred
  • Pancreatitis acute (sudden inflammation of pancreas)
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Sepsis (a severe blood infection that can lead to organ failure and death)
  • Rash
50-59:
  • Vomiting
  • Lactic acidosis (low ph in body tissues)
  • Completed suicide (act of taking one's own life)
  • Weight decreased
  • Renal failure acute (rapid kidney dysfunction)
  • Weight increased
  • Blood glucose increased
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Pancreatitis (inflammation of pancreas)
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
60+:
  • Vomiting
  • Lactic acidosis (low ph in body tissues)
  • Renal failure acute (rapid kidney dysfunction)
  • Weight decreased
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Nausea (feeling of having an urge to vomit)
  • Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  • Renal failure (kidney dysfunction)
  • Renal impairment (severely reduced kidney function)
  • Weight increased

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study

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On eHealthMe, Metformin hydrochloride (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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