Methotrexate: effectiveness, side effects, alternatives
Summary:
Methotrexate: methotrexate sodium
We study 521,868 Methotrexate users. The information eHealthMe analyzes includes:
- Effectiveness of Methotrexate- 88 alternative drugs to Methotrexate
- 11,805 Methotrexate side effects and drug interactions
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
Number of reports submitted per year:

How effective is Methotrexate?
- Rheumatoid arthritis - reported by 1,427 people
- Psoriatic arthritis - reported by 316 people
- Arthritis - reported by 159 people
- Psoriasis - reported by 155 people
- Systemic lupus erythematosus - reported by 78 people
- Ankylosing spondylitis - reported by 55 people
- Crohn's disease - reported by 45 people
- Juvenile rheumatoid arthritis - reported by 31 people
- Sarcoidosis - reported by 30 people
- Rheumatoid factor negative - reported by 29 people
- Rheumatoid factor positive - reported by 27 people
- Dermatomyositis - reported by 22 people
- Autoimmune disorder - reported by 22 people
- Psoriatic arthropathy - reported by 21 people
- Mixed connective tissue disease - reported by 18 people
- Uveitis - reported by 17 people
- Eczema - reported by 15 people
- Reiter syndrome - reported by 13 people
- Inflammatory pain - reported by 12 people
- Sjogren syndrome - reported by 11 people
- Wegener's granulomatosis - reported by 11 people
- Osteoarthritis - reported by 10 people
- Spondyloarthropathy - reported by 10 people
- Ulcerative colitis - reported by 9 people
- Systemic sclerosis (scleroderma) - reported by 9 people
- Ectopic pregnancy - reported by 8 people
- Polymyositis - adult - reported by 8 people
- Psoriasis - guttate - reported by 8 people
- Joint pain - reported by 6 people
- Pulmonary sarcoidosis - reported by 6 people
- Inflammation - reported by 4 people
- Pain - reported by 3 people
- Pustular psoriasis - reported by 3 people
Alternative drugs to the conditions Methotrexate treats:
- Rheumatoid arthritis
- Psoriatic arthritis
- Arthritis
- Psoriasis
- Systemic lupus erythematosus
- Ankylosing spondylitis
- Crohn's disease
- Juvenile rheumatoid arthritis
- Sarcoidosis
- Rheumatoid factor negative
- Rheumatoid factor positive
- Dermatomyositis
- Autoimmune disorder
- Psoriatic arthropathy
- Mixed connective tissue disease
- Uveitis
- Eczema
- Reiter syndrome
- Inflammatory pain
- Sjogren syndrome
- Wegener's granulomatosis
- Osteoarthritis
- Spondyloarthropathy
- Ulcerative colitis
- Systemic sclerosis (scleroderma)
- Ectopic pregnancy
- Polymyositis - adult
- Psoriasis - guttate
- Joint pain
- Pulmonary sarcoidosis
- Inflammation
- Pain
- Pustular psoriasis
Compare Methotrexate with similar drugs, by side effects and effectiveness:
- Methotrexate vs. Acetaminophen
- Methotrexate vs. Actemra
- Methotrexate vs. Advil
- Methotrexate vs. Aleve
- Methotrexate vs. Arava
- Methotrexate vs. Arthrotec
- Methotrexate vs. Aspirin
- Methotrexate vs. Azathioprine
- Methotrexate vs. Azulfidine
- Methotrexate vs. Azulfidine en-tabs
- Methotrexate vs. Calcium
- Methotrexate vs. Celebrex
- Methotrexate vs. Cimzia
- Methotrexate vs. Cortisone acetate
- Methotrexate vs. Curcumin
- Methotrexate vs. Cyclobenzaprine hydrochloride
- Methotrexate vs. Cymbalta
- Methotrexate vs. Diclofenac sodium
- Methotrexate vs. Enbrel
- Methotrexate vs. Ergocalciferol
- Methotrexate vs. Etodolac
- Methotrexate vs. Fish oil
- Methotrexate vs. Flexeril
- Methotrexate vs. Flurbiprofen
- Methotrexate vs. Folate
- Methotrexate vs. Folic acid
- Methotrexate vs. Gabapentin
- Methotrexate vs. Humira
- Methotrexate vs. Hydrocodone bitartrate and acetaminophen
- Methotrexate vs. Hydroxychloroquine sulfate
- Methotrexate vs. Ibu
- Methotrexate vs. Ibuprofen
- Methotrexate vs. Imuran
- Methotrexate vs. Indomethacin
- Methotrexate vs. Ketoprofen
- Methotrexate vs. Kineret
- Methotrexate vs. Leflunomide
- Methotrexate vs. Leucovorin calcium
- Methotrexate vs. Lodine
- Methotrexate vs. Lortab
- Methotrexate vs. Lyrica
- Methotrexate vs. Medrol
- Methotrexate vs. Meloxicam
- Methotrexate vs. Methylprednisolone
- Methotrexate vs. Minocycline hydrochloride
- Methotrexate vs. Mobic
- Methotrexate vs. Morphine sulfate
- Methotrexate vs. Nabumetone
- Methotrexate vs. Naprosyn
- Methotrexate vs. Naproxen
- Methotrexate vs. Naproxen sodium
- Methotrexate vs. Neurontin
- Methotrexate vs. Norco
- Methotrexate vs. Nuvigil
- Methotrexate vs. Omeprazole
- Methotrexate vs. Orencia
- Methotrexate vs. Oxycodone and acetaminophen
- Methotrexate vs. Oxycontin
- Methotrexate vs. Paracetamol
- Methotrexate vs. Percocet
- Methotrexate vs. Piroxicam
- Methotrexate vs. Plaquenil
- Methotrexate vs. Potassium chloride
- Methotrexate vs. Prednisolone
- Methotrexate vs. Prednisolone sodium phosphate
- Methotrexate vs. Prednisone
- Methotrexate vs. Profen
- Methotrexate vs. Relafen
- Methotrexate vs. Remicade
- Methotrexate vs. Rituxan
- Methotrexate vs. Savella
- Methotrexate vs. Simponi
- Methotrexate vs. Sulfadiazine
- Methotrexate vs. Sulfapyridine
- Methotrexate vs. Sulfasalazine
- Methotrexate vs. Sulindac
- Methotrexate vs. Tizanidine hydrochloride
- Methotrexate vs. Tramadol
- Methotrexate vs. Tramadol hydrochloride
- Methotrexate vs. Turmeric
- Methotrexate vs. Tylenol
- Methotrexate vs. Ultram
- Methotrexate vs. Vicodin
- Methotrexate vs. Vimovo
- Methotrexate vs. Vitamin d
- Methotrexate vs. Voltaren
- Methotrexate vs. Xeljanz
- Methotrexate vs. Zorvolex
Common Methotrexate side effects:
- Drug ineffective (104,668 reports)
- Rheumatoid arthritis (52,705 reports)
- Joint pain (45,719 reports)
- Pain (44,785 reports)
- Fatigue (36,266 reports)
- Rashes (30,738 reports)
- Joint swelling (29,058 reports)
Methotrexate side effects by duration, gender and age:
- Methotrexate side effects (517,588 reports)
Browse all side effects of Methotrexate:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon Methotrexate interactions:
- Methotrexate and Enbrel (140,549 reports)
- Methotrexate and Humira (129,969 reports)
- Methotrexate and Prednisone (112,716 reports)
- Methotrexate and Remicade (59,697 reports)
- Methotrexate and Folic acid (54,751 reports)
- Methotrexate and Orencia (53,972 reports)
- Methotrexate and Sulfasalazine (51,755 reports)
- Methotrexate and Xeljanz (51,753 reports)
- Methotrexate and Actemra (50,659 reports)
- Methotrexate and Plaquenil (45,447 reports)
Browse all interactions between Methotrexate and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zDo you take Methotrexate?
- You can start a phase IV clinical trial to monitor Methotrexate safety and effectiveness.Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
Related publications that referenced our studies
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
How we gather our data?
Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference. Browse all drugs on eHealthMe.
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