Nicotine side effects by duration, gender and age - a phase IV clinical study of FDA data
Summary:
Side effects are reported by people who take Nicotine. Common side effects include drug ineffective among females and drug ineffective among males.
The phase IV clinical study is created by eHealthMe based on 16,521 reports from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.
16,521 people who take Nicotine and have side effects are studied.
What is Nicotine?
Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 16,817 Nicotine users for its effectiveness, alternative drugs and more.
Number of Nicotine reports submitted per year:

Nicotine side effects by time on the drug *:
Nicotine side effects by gender *:
Nicotine side effects by age *:
* Approximation only. Some reports may have incomplete information.
Do you take Nicotine?
Personalize this study to your gender and ageHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
How the study uses the data?
The study is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.
Related studies
Alternative drugs to, pros and cons of Nicotine:
- Nicotine (16,817 reports)
Common Nicotine side effects:
- Abdominal discomfort: 124 reports
- Abdominal distension: 111 reports
- Abdominal pain: 222 reports
- Abdominal pain upper: 188 reports
- Abnormal dreams: 281 reports
- Accidental overdose (therapeutic agent): 281 reports
- Acute kidney failure: 232 reports
- Aggression: 102 reports
- Agitation (state of anxiety or nervous excitement): 250 reports
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 104 reports
- Anaemia (lack of blood): 188 reports
- Anger: 140 reports
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 128 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 193 reports
- Application site erythema (redness of the skin at application site): 505 reports
- Application site irritation: 122 reports
- Application site pain: 236 reports
- Application site pruritus (application site severe itching of the skin): 455 reports
- Application site rash: 318 reports
- Application site reaction: 143 reports
- Application site swelling: 110 reports
- Arrhythmias (irregular heartbeat): 231 reports
- Asthma: 150 reports
- Back pain: 240 reports
- Blood creatinine increased: 106 reports
- Blood glucose increased: 137 reports
- Breathing difficulty: 736 reports
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 147 reports
- Cardiac arrest: 110 reports
- Cellulitis (infection under the skin): 107 reports
- Chest pain: 478 reports
- Chronic kidney disease: 213 reports
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 252 reports
- Completed suicide (act of taking one's own life): 168 reports
- Confusional state: 232 reports
- Constipation: 243 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 162 reports
- Cough: 269 reports
- Death: 282 reports
- Dehydration (dryness resulting from the removal of water): 141 reports
- Dependence: 119 reports
- Depressed mood: 126 reports
- Depression: 441 reports
- Diabetes: 112 reports
- Diarrhea: 451 reports
- Disturbance in attention: 111 reports
- Dizziness: 801 reports
- Drowsiness: 279 reports
- Drug abuse and dependence: 338 reports
- Drug administration error: 120 reports
- Drug dependence: 507 reports
- Drug hypersensitivity: 171 reports
- Drug ineffective: 1,456 reports
- Drug toxicity: 166 reports
- Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 231 reports
- Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 435 reports
- Dry mouth: 113 reports
- Emotional distress: 143 reports
- Fainting (loss of consciousness and postural tone): 152 reports
- Fall: 274 reports
- Fatigue (feeling of tiredness): 558 reports
- Fever: 312 reports
- Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 823 reports
- Gait disturbance: 173 reports
- Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 140 reports
- General physical health deterioration (weak health status): 106 reports
- Hallucinations (sensations that appear real but are created by your mind): 183 reports
- Headache (pain in head): 642 reports
- Head injury: 133 reports
- Heart attack: 245 reports
- Heart palpitations (feelings or sensations that your heart is pounding or racing): 278 reports
- Heart rate increased: 195 reports
- High blood cholesterol: 116 reports
- High blood pressure: 506 reports
- Hyperhidrosis (abnormally increased sweating): 264 reports
- Hypersensitivity: 254 reports
- Hypoaesthesia (reduced sense of touch or sensation): 185 reports
- Hypotension (abnormally low blood pressure): 383 reports
- Indigestion: 124 reports
- Injury: 153 reports
- Insomnia (sleeplessness): 474 reports
- Irritability: 219 reports
- Itching: 303 reports
- Jaundice neonatal (yellowing of skin in neonate): 122 reports
- Joint pain: 206 reports
- Loss of consciousness: 325 reports
- Low birth weight baby: 190 reports
- Malaise (a feeling of general discomfort or uneasiness): 527 reports
- Maternal exposure during pregnancy (use of substance during pregnancy): 485 reports
- Memory loss: 166 reports
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 101 reports
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 105 reports
- Mood swings (an extreme or rapid change in mood): 123 reports
- Multiple drug overdose: 147 reports
- Muscle aches (muscle pain): 135 reports
- Muscle spasms (muscle contraction): 122 reports
- Nausea (feeling of having an urge to vomit): 1,088 reports
- Nausea and vomiting: 589 reports
- Nervousness: 173 reports
- Nicotine dependence: 845 reports
- Nightmares (unpleasant dreams): 190 reports
- Oedema peripheral (superficial swelling): 169 reports
- Overdose: 826 reports
- Pain: 498 reports
- Pain in extremity: 301 reports
- Panic disorder: 136 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 233 reports
- Pleural effusion (water on the lungs): 137 reports
- Pneumonia: 391 reports
- Premature baby: 357 reports
- Premature delivery: 269 reports
- Pulmonary embolism (blockage of the main artery of the lung): 124 reports
- Pulmonary oedema (fluid accumulation in the lungs): 209 reports
- Quit smoking: 111 reports
- Rashes (redness): 644 reports
- Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 204 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 144 reports
- Sleep disorder: 161 reports
- Speech impairment (adult) (inability to speak (adult)): 136 reports
- Stress and anxiety: 762 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 149 reports
- Suicidal ideation: 214 reports
- Swelling: 111 reports
- Thrombocytopenia (decrease of platelets in blood): 136 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 296 reports
- Urinary tract infection: 169 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 166 reports
- Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital)): 122 reports
- Vision blurred: 156 reports
- Weakness: 412 reports
- Weight decreased: 246 reports
- Weight increased: 216 reports
- Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 137 reports
All Nicotine side effects from A to Z:
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With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
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