Nolvadex side effects - from FDA reports


In this review, we analyze Nolvadex side effects by the time on the drug, gender and age of the people who have side effects while taking Nolvadex. The review is based on 4,941 people who have side effects while taking the drug from FDA, and is updated regularly.

Nolvadex

Nolvadex has active ingredients of tamoxifen citrate. It is often used in breast cancer. (latest outcomes from Nolvadex 5,004 users)


On Jul, 21, 2018

4,941 people who take Nolvadex are studied.


Number of reports submitted per year:

Nolvadex side effects.

Most common side effects over time *:

< 1 month:
  • Upper respiratory tract inflammation
  • Pyrexia (fever)
  • White blood cell count decreased
  • Renal failure (kidney dysfunction)
  • Choroiditis (infection of vascular layer of eye)
  • Drug exposure during pregnancy
  • Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
  • Pleural effusion (water on the lungs)
  • Rash
  • Weight increased
1 - 6 months:
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  • Bone callus excessive (excessive bony deposit formed between and around the broken ends of bone fractures)
  • Visual acuity reduced (reduced clearness of vision)
  • Weight increased
  • Yellow skin
  • Alanine aminotransferase abnormal
  • Arthralgia (joint pain)
  • Bone disorder
  • Cerebral venous thrombosis (clot in brains venous blood system)
6 - 12 months:
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Thrombocytopenia (decrease of platelets in blood)
  • Acute leukaemia (blood cancer)
  • Cellulitis (infection under the skin)
  • Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
  • Pyrexia (fever)
  • Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  • Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
  • Arthralgia (joint pain)
  • Autoimmune neutropenia (autoimmune neutropenia is abnormally low level of neutrophils in the blood)
1 - 2 years:
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  • Metrorrhagia (uterine bleeding at irregular intervals)
  • Alopecia (absence of hair from areas of the body)
  • Hepatic steatosis (fatty liver disease)
  • Vaginal haemorrhage (vaginal bleeding)
  • Abscess oral (abscess in the mouth)
  • Anaemia (lack of blood)
  • Endometrial hypertrophy (enlargement of uterine wall from the increase in size of its cells)
  • Hepatic failure (liver failure)
2 - 5 years:
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Cerebral infarction (less blood supply to brain resulting tissue damage)
  • Endometrial hyperplasia (enlargement of uterus wall)
  • Cyst (a closed sac)
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Hepatic steatosis (fatty liver disease)
  • Tooth extraction
  • Arthralgia (joint pain)
  • Endometrial cancer
  • Uterine cancer
5 - 10 years:
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Weight increased
  • Osteoporosis (bones weak and more likely to break)
  • Pleural effusion (water on the lungs)
  • Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  • Vaginal cancer
  • Cataract (clouding of the lens inside the eye)
  • Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)
  • Wrist fracture
  • Endometrial hyperplasia (enlargement of uterus wall)
10+ years:
  • Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
  • Myalgia (muscle pain)
  • Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  • Cervix carcinoma (cancer of cervix)
  • Endometrial cancer
  • Haemolytic anaemia (anaemia due to haemolysis)
  • Neoplasm malignant (cancer tumour)
  • Vulvitis (inflammation of the vulva)
not specified:
  • Death
  • Weight increased
  • Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Vaginal haemorrhage (vaginal bleeding)
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Weight decreased
  • Breast cancer stage iv
  • Nausea (feeling of having an urge to vomit)
  • Thrombocytopenia (decrease of platelets in blood)

Most common side effects by gender *:

female:
  • Death
  • Weight increased
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Vaginal haemorrhage (vaginal bleeding)
  • Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
  • Weight decreased
  • Endometrial hyperplasia (enlargement of uterus wall)
  • Breast cancer stage iv
  • Thrombocytopenia (decrease of platelets in blood)
male:
  • Death
  • Osteoporosis (bones weak and more likely to break)
  • Toothache (tooth pain)
  • Prostate cancer
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Anxiety disorder
  • Malaise (a feeling of general discomfort or uneasiness)
  • Memory impairment
  • Weight increased
  • Lung disorder (lung disease)

Most common side effects by age *:

0-1:
  • Pleural effusion (water on the lungs)
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Vaginal haemorrhage (vaginal bleeding)
  • Cervical polyp (tumour on the surface of the cervical canal)
  • Laryngeal granuloma (a small area of inflammation due to tissue injury in larynx)
  • Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  • Osteoporosis (bones weak and more likely to break)
  • Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
  • Cerebral infarction (less blood supply to brain resulting tissue damage)
  • Cervix carcinoma (cancer of cervix)
2-9:
  • Accidental overdose
10-19:
  • Faecaloma (hard mass of fecal matter)
  • Tumour marker increased
20-29:
  • Vaginal haemorrhage (vaginal bleeding)
  • Anxiety disorder
  • Weight increased
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
  • Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  • Impaired healing
  • Multiple congenital abnormalities (more than one birth defects)
  • Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
  • Sleep disorder
30-39:
  • Death
  • Weight increased
  • Interstitial lung disease
  • Urinary retention (the inability to completely or partially empty the bladder)
  • Abasia (inability to walk)
  • Back pain
  • Drug exposure during pregnancy
  • Thrombotic thrombocytopenic purpura (a rare blood disorder characterized by clotting in small blood vessels of the body)
  • Tremor (trembling or shaking movements in one or more parts of your body)
  • Vulvovaginal dryness
40-49:
  • Death
  • Weight increased
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Anaemia (lack of blood)
  • Upper respiratory tract inflammation
  • Vaginal haemorrhage (vaginal bleeding)
  • Arthralgia (joint pain)
  • Cerebral infarction (less blood supply to brain resulting tissue damage)
50-59:
  • Weight increased
  • Death
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Endometrial hyperplasia (enlargement of uterus wall)
  • Pyrexia (fever)
  • Tooth extraction
  • Vaginal haemorrhage (vaginal bleeding)
  • Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
  • Thrombocytopenia (decrease of platelets in blood)
  • Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
60+:
  • Death
  • Pulmonary embolism (blockage of the main artery of the lung)
  • Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
  • Vaginal haemorrhage (vaginal bleeding)
  • Weight increased
  • Uterine polyp (a mass in the inner lining of the uterus)
  • Breast cancer stage iv
  • Weight decreased
  • Thrombocytopenia (decrease of platelets in blood)
  • Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Subscribe to the study: get notified of updates to the study.

Do you have side effects when taking Nolvadex? Share you experience to help people like you.

Want to find out more about the FDA reports used in the study? You can request them from FDA.

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On eHealthMe, Nolvadex (tamoxifen citrate) is often used to treat breast cancer. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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