Simvastatin side effects - from FDA reports


In this review, we analyze Simvastatin side effects by the time on the drug, gender and age of the people who have side effects while taking Simvastatin. The review is based on 170,126 people who have side effects while taking the drug from FDA, and is updated regularly.

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Simvastatin

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 176,727 users)


On Jan, 08, 2019

170,126 people who take Simvastatin are studied.


Number of reports submitted per year:

Simvastatin side effects.

Most common side effects over time *:

< 1 month:
  • Myalgia (muscle pain)
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Vomiting
  • Muscle spasms (muscle contraction)
  • Sopor (sleep)
  • Pain in extremity
  • Renal failure acute (rapid kidney dysfunction)
  • Panic attack
  • Rash
  • Vision blurred
1 - 6 months:
  • Pain
  • Pain in extremity
  • Vomiting
  • Renal failure acute (rapid kidney dysfunction)
  • Blood creatine phosphokinase increased
  • Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  • Swelling face
  • Cough
  • Nausea (feeling of having an urge to vomit)
  • Muscular weakness (muscle weakness)
6 - 12 months:
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Myalgia (muscle pain)
  • Rectal haemorrhage (bleeding from anus)
  • Myositis (inflammation of the muscles)
  • Pain in extremity
  • Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  • Blood creatine phosphokinase increased
  • Vomiting
  • Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  • Tendon rupture (tear of tendon)
1 - 2 years:
  • Myalgia (muscle pain)
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Weight decreased
  • Pain in extremity
  • Vomiting
  • Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  • Sleep disorder
  • Vertigo
  • Interstitial lung disease
  • Myopathy (a muscular disease in which the muscle fibres do not function)
2 - 5 years:
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Myalgia (muscle pain)
  • Muscular weakness (muscle weakness)
  • Pain in extremity
  • Myositis (inflammation of the muscles)
  • Vomiting
  • Sleep disorder
  • Weight decreased
  • Asthenia (weakness)
  • Muscle atrophy (a decrease in the mass of the muscle)
5 - 10 years:
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Pain in extremity
  • Myalgia (muscle pain)
  • Tendon rupture (tear of tendon)
  • Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  • Muscular weakness (muscle weakness)
  • Renal tubular necrosis (death of kidney tubules)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Weight decreased
  • Renal failure (kidney dysfunction)
10+ years:
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Myalgia (muscle pain)
  • Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
  • Pruritus generalised (generalized itching)
  • Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  • Back pain
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Renal failure (kidney dysfunction)
  • Renal failure acute (rapid kidney dysfunction)
  • Swollen tongue (swelling of tongue)
not specified:
  • Vomiting
  • Weight decreased
  • Drug ineffective
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Weight increased
  • Death
  • Nausea (feeling of having an urge to vomit)
  • Pneumonia
  • Rash
  • Pain

Most common side effects by gender *:

female:
  • Vomiting
  • Weight decreased
  • Weight increased
  • Drug ineffective
  • Nausea (feeling of having an urge to vomit)
  • Pain
  • Urinary tract infection
  • Pain in extremity
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Rash
male:
  • Weight decreased
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Syncope (loss of consciousness with an inability to maintain postural tone)
  • Pain in extremity
  • Renal failure acute (rapid kidney dysfunction)
  • Weight increased
  • Nausea (feeling of having an urge to vomit)
  • Dyspnoea (difficult or laboured respiration)
  • Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  • Renal failure (kidney dysfunction)

Most common side effects by age *:

0-1:
  • Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital))
  • Swollen tongue (swelling of tongue)
  • Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  • Skin necrosis (skin damage)
  • Underweight
  • Acute respiratory distress syndrome
  • Confusional state
  • Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  • Hypospadias (an abnormal condition in males in which the urethra opens on the under surface of the penis)
  • Weight decreased
2-9:
  • Accidental drug intake by child
  • Hypoglycaemia (deficiency of glucose in the bloodstream)
  • Nightmare (unpleasant dream)
  • Accidental exposure
  • Chest pain
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle)
  • Abnormal behaviour
  • Influenza like illness
  • Weight decreased
10-19:
  • Vomiting
  • Myositis (inflammation of the muscles)
  • Renal failure (kidney dysfunction)
  • Weight increased
  • Aspartate aminotransferase increased
  • Multiple drug overdose intentional
  • Rib fracture
  • Congestive cardiomyopathy (weakening of heart muscle)
  • Drug ineffective
  • Hyperkalaemia (damage to or disease of the kidney)
20-29:
  • Weight decreased
  • White blood cell count increased
  • Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  • Hyperthyroidism (over activity of the thyroid gland)
  • Renal failure (kidney dysfunction)
  • Blindness
  • Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
  • Pyrexia (fever)
  • Urticaria (rash of round, red welts on the skin that itch intensely)
  • Anaemia (lack of blood)
30-39:
  • Agitation (state of anxiety or nervous excitement)
  • Vomiting
  • Completed suicide (act of taking one's own life)
  • Weight increased
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Weight decreased
  • White blood cell count increased
  • Myalgia (muscle pain)
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Abdominal pain
40-49:
  • Vomiting
  • Myalgia (muscle pain)
  • Weight increased
  • Pain
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Weight decreased
  • Nausea (feeling of having an urge to vomit)
  • Somnolence (a state of near-sleep, a strong desire for sleep)
  • Drug ineffective
  • Vision blurred
50-59:
  • Vomiting
  • Weight decreased
  • Myalgia (muscle pain)
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Weight increased
  • Drug ineffective
  • Nausea (feeling of having an urge to vomit)
  • Pain in extremity
  • Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  • Pain
60+:
  • Vomiting
  • Weight decreased
  • Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  • Drug ineffective
  • Death
  • Nausea (feeling of having an urge to vomit)
  • Pneumonia
  • Myalgia (muscle pain)
  • Syncope (loss of consciousness with an inability to maintain postural tone)
  • Urinary tract infection

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study

You are not alone:

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On eHealthMe, Simvastatin (simvastatin) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for and how effective they are.

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