Accutane and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is reported only by a few people who take Accutane.

The phase IV clinical study analyzes which people take Accutane and have Dupuytren's contracture. It is created by eHealthMe based on reports of 31,306 people who have side effects while taking Accutane from the FDA, and is updated regularly.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 30, 2022

31,306 people reported to have side effects when taking Accutane.
Among them, 4 people (0.01%) have Dupuytren's contracture.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 32,871 Accutane users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 435 drugs and 194 conditions by eHealthMe.

Number of Accutane and Dupuytren's contracture reports submitted per year:

Could Accutane cause Dupuytren's contracture?

Time on Accutane when people have Dupuytren's contracture *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 75 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 25 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking Accutane *:

  • female: 25 %
  • male: 75 %

Age of people who have Dupuytren's contracture when taking Accutane *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 100 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Accutane *:

  1. Zometa: 1 person, 25.00%
  2. Finasteride: 1 person, 25.00%
  3. Amoxicillin: 1 person, 25.00%
  4. Aredia: 1 person, 25.00%
  5. Carvedilol: 1 person, 25.00%
  6. Celexa: 1 person, 25.00%
  7. Centrum Silver: 1 person, 25.00%
  8. Cephalexin: 1 person, 25.00%
  9. Colace: 1 person, 25.00%
  10. Cyclophosphamide: 1 person, 25.00%

Common side effects people have besides Dupuytren's contracture *:

  1. Chest Pain: 4 people, 100.00%
  2. Hypotension (abnormally low blood pressure): 4 people, 100.00%
  3. Cardiac Failure Congestive: 4 people, 100.00%
  4. Back Pain: 4 people, 100.00%
  5. Stress And Anxiety: 4 people, 100.00%
  6. Inflammatory Bowel Disease: 4 people, 100.00%
  7. Neuropathy Peripheral (surface nerve damage): 4 people, 100.00%
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 100.00%
  9. Upper Respiratory Tract Infection: 4 people, 100.00%
  10. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 100.00%

Common conditions people have *:

  1. Multiple Myeloma (cancer of the plasma cells): 1 person, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Accutane and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Accutane:

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of isotretinoin:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Accutane) and Accutane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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