Accutane and Premature menopause - a phase IV clinical study of FDA data


Premature menopause is found among people who take Accutane, especially for people who are 30-39 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Accutane and have Premature menopause. It is created by eHealthMe based on reports of 32,000 people who have side effects when taking Accutane from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On May, 08, 2023

32,000 people reported to have side effects when taking Accutane.
Among them, 17 people (0.05%) have Premature menopause.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 33,706 Accutane users for its effectiveness, alternative drugs and more.

What is Premature menopause?

Premature menopause is found to be associated with 479 drugs and 258 conditions by eHealthMe.

Number of Accutane and Premature menopause reports submitted per year:

Could Accutane cause Premature menopause?

Time on Accutane when people have Premature menopause *:

  • < 1 month: 33.33 %
  • 1 - 6 months: 66.67 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Age of people who have Premature menopause when taking Accutane *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 7.69 %
  • 30-39: 53.85 %
  • 40-49: 38.46 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Accutane *:

  1. Provera: 3 people, 17.65%
  2. Synthroid: 1 person, 5.88%
  3. Sotret: 1 person, 5.88%
  4. Sertraline: 1 person, 5.88%
  5. Seroquel: 1 person, 5.88%
  6. Prilosec: 1 person, 5.88%
  7. Prevacid: 1 person, 5.88%
  8. Metformin: 1 person, 5.88%
  9. Lipitor: 1 person, 5.88%
  10. Aleve: 1 person, 5.88%

Common side effects people have besides Premature menopause *:

  1. Fatigue (feeling of tiredness): 3 people, 17.65%
  2. Arthritis Reactive (autoimmune condition that develops in response to an infection in another part of the body): 3 people, 17.65%
  3. Constipation: 3 people, 17.65%
  4. Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 3 people, 17.65%
  5. Joint Pain: 3 people, 17.65%
  6. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 17.65%
  7. Tendonitis (a condition that causes pain and swelling of tendons): 3 people, 17.65%
  8. Back Pain: 2 people, 11.76%
  9. Birth Control: 2 people, 11.76%
  10. Plantar Fasciitis (painful inflammatory process of the plantar fascia): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Accutane and have Premature menopause?

Check whether Premature menopause is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Premature menopause and when was it recovered:

Expand to all the drugs that have ingredients of isotretinoin:

Alternative drugs to, pros and cons of Accutane:

Common Accutane side effects:

Browse all side effects of Accutane:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Premature menopause treatments and more:

COVID vaccines that are related to Premature menopause:

Common drugs associated with Premature menopause:

All the drugs that are associated with Premature menopause:

All the conditions that are associated with Premature menopause:

How the study uses the data?

The study uses data from the FDA. It is based on isotretinoin (the active ingredients of Accutane) and Accutane (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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