Acetaminophen and Diaphragmatic hernia - a phase IV clinical study of FDA data


Diaphragmatic hernia is found among people who take Acetaminophen, especially for people who are female, 30-39 old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Acetaminophen and have Diaphragmatic hernia. It is created by eHealthMe based on reports of 106,002 people who have side effects when taking Acetaminophen from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 17, 2022

106,002 people reported to have side effects when taking Acetaminophen.
Among them, 20 people (0.02%) have Diaphragmatic hernia.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 107,871 Acetaminophen users for its effectiveness, alternative drugs and more.

What is Diaphragmatic hernia?

Diaphragmatic hernia (defect or hole in the diaphragm that allows the abdominal contents to move into the chest cavity) is found to be associated with 432 drugs and 197 conditions by eHealthMe.

Number of Acetaminophen and Diaphragmatic hernia reports submitted per year:

Could Acetaminophen cause Diaphragmatic hernia?

Time on Acetaminophen when people have Diaphragmatic hernia *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Diaphragmatic hernia when taking Acetaminophen *:

  • female: 80 %
  • male: 20 %

Age of people who have Diaphragmatic hernia when taking Acetaminophen *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 5.26 %
  • 20-29: 0.0 %
  • 30-39: 63.16 %
  • 40-49: 0.0 %
  • 50-59: 21.05 %
  • 60+: 10.53 %

Common drugs people take besides Acetaminophen *:

  1. Levaquin: 17 people, 85.00%
  2. Ondansetron: 16 people, 80.00%
  3. Aredia: 16 people, 80.00%
  4. Ambien: 16 people, 80.00%
  5. Zofran: 15 people, 75.00%
  6. Duragesic-100: 15 people, 75.00%
  7. Pepcid: 14 people, 70.00%
  8. Percocet: 14 people, 70.00%
  9. Lisinopril: 14 people, 70.00%
  10. Zometa: 14 people, 70.00%

Common side effects people have besides Diaphragmatic hernia *:

  1. Anaemia (lack of blood): 18 people, 90.00%
  2. Weight Decreased: 17 people, 85.00%
  3. Stress And Anxiety: 17 people, 85.00%
  4. Haemorrhoids (a swollen vein or group of veins in the region of the anus): 17 people, 85.00%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 17 people, 85.00%
  6. Osteonecrosis Of Jaw (death of bone of jaw): 17 people, 85.00%
  7. Abdominal Pain: 17 people, 85.00%
  8. Urinary Tract Infection: 16 people, 80.00%
  9. Fall: 16 people, 80.00%
  10. Swallowing Difficulty: 16 people, 80.00%

Common conditions people have *:

  1. Metastases To Bone (cancer spreads to bone): 13 people, 65.00%
  2. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 13 people, 65.00%
  3. Breast Cancer: 10 people, 50.00%
  4. Multiple Myeloma (cancer of the plasma cells): 4 people, 20.00%
  5. Light Chain Analysis Increased: 3 people, 15.00%
  6. Post-Traumatic Epilepsy: 1 person, 5.00%
  7. Impaired Gastric Emptying: 1 person, 5.00%
  8. Endometrial Cancer: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and have Diaphragmatic hernia?

Check whether Diaphragmatic hernia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

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Common Acetaminophen side effects:

Browse all side effects of Acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Diaphragmatic hernia treatments and more:

COVID vaccines that are related to Diaphragmatic hernia:

All the drugs that are associated with Diaphragmatic hernia:

All the conditions that are associated with Diaphragmatic hernia:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Acetaminophen) and Acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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