Actonel and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Actonel, especially for people who are female, 40-49 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Actonel and have Dupuytren's contracture. It is created by eHealthMe based on reports of 27,432 people who have side effects when taking Actonel from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On May, 04, 2022

27,432 people reported to have side effects when taking Actonel.
Among them, 22 people (0.08%) have Dupuytren's contracture.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 27,865 Actonel users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 435 drugs and 194 conditions by eHealthMe.

Number of Actonel and Dupuytren's contracture reports submitted per year:

Could Actonel cause Dupuytren's contracture?

Time on Actonel when people have Dupuytren's contracture *:

  • < 1 month: 28.57 %
  • 1 - 6 months: 14.29 %
  • 6 - 12 months: 28.57 %
  • 1 - 2 years: 14.29 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 14.29 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking Actonel *:

  • female: 90.91 %
  • male: 9.09 %

Age of people who have Dupuytren's contracture when taking Actonel *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 52.63 %
  • 50-59: 15.79 %
  • 60+: 31.58 %

Common drugs people take besides Actonel *:

  1. Fosamax: 12 people, 54.55%
  2. Miacalcin: 10 people, 45.45%
  3. Hydrocortisone: 6 people, 27.27%
  4. Norvasc: 6 people, 27.27%
  5. Serevent: 2 people, 9.09%
  6. Claritin: 2 people, 9.09%
  7. Celebrex: 2 people, 9.09%
  8. Lipitor: 2 people, 9.09%
  9. Carafate: 2 people, 9.09%
  10. Boniva: 2 people, 9.09%

Common side effects people have besides Dupuytren's contracture *:

  1. Depression: 13 people, 59.09%
  2. Stress And Anxiety: 13 people, 59.09%
  3. Abdominal Pain: 12 people, 54.55%
  4. Migraine (headache): 11 people, 50.00%
  5. Osteomyelitis (infection of bone): 11 people, 50.00%
  6. Periodontitis (inflammation of the tissue around the teeth): 11 people, 50.00%
  7. Hair Loss: 10 people, 45.45%
  8. Plantar Fasciitis (painful inflammatory process of the plantar fascia): 10 people, 45.45%
  9. Adrenal Insufficiency (condition in which the adrenal glands do not produce adequate amounts of steroids): 10 people, 45.45%
  10. Breathing Difficulty: 10 people, 45.45%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.09%
  2. Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 9.09%
  3. Metastases To Prostate (cancer spreads to prostate): 1 person, 4.55%
  4. Asthma: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Alternative drugs to, pros and cons of Actonel:

Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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