Actonel and Oesophageal carcinoma - a phase IV clinical study of FDA data


Oesophageal carcinoma is found among people who take Actonel, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Actonel and have Oesophageal carcinoma. It is created by eHealthMe based on reports of 28,020 people who have side effects when taking Actonel from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

28,020 people reported to have side effects when taking Actonel.
Among them, 23 people (0.08%) have Oesophageal carcinoma.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 28,455 Actonel users for its effectiveness, alternative drugs and more.

What is Oesophageal carcinoma?

Oesophageal carcinoma (cancer tumour of oesophagus) is found to be associated with 759 drugs and 388 conditions by eHealthMe.

Number of Actonel and Oesophageal carcinoma reports submitted per year:

Could Actonel cause Oesophageal carcinoma?

Time on Actonel when people have Oesophageal carcinoma *:

  • < 1 month: 25.0 %
  • 1 - 6 months: 12.5 %
  • 6 - 12 months: 12.5 %
  • 1 - 2 years: 12.5 %
  • 2 - 5 years: 25.0 %
  • 5 - 10 years: 12.5 %
  • 10+ years: 0.0 %

Gender of people who have Oesophageal carcinoma when taking Actonel *:

  • female: 77.27 %
  • male: 22.73 %

Age of people who have Oesophageal carcinoma when taking Actonel *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 6.25 %
  • 50-59: 6.25 %
  • 60+: 87.5 %

Common drugs people take besides Actonel *:

  1. Calcium Citrate: 4 people, 17.39%
  2. Vitamin D: 3 people, 13.04%
  3. Crestor: 3 people, 13.04%
  4. Nicorette: 2 people, 8.70%
  5. Imuran: 1 person, 4.35%
  6. Fish Oil: 1 person, 4.35%
  7. Enbrel: 1 person, 4.35%
  8. Cellcept: 1 person, 4.35%
  9. Celebrex: 1 person, 4.35%
  10. Vitamin E: 1 person, 4.35%

Common side effects people have besides Oesophageal carcinoma *:

  1. Indigestion: 6 people, 26.09%
  2. Abdominal Discomfort: 4 people, 17.39%
  3. Joint Pain: 3 people, 13.04%
  4. Swallowing Difficulty: 3 people, 13.04%
  5. Device Dislocation: 3 people, 13.04%
  6. Death: 2 people, 8.70%
  7. Joint Crepitation: 2 people, 8.70%
  8. Muscle Aches (muscle pain): 2 people, 8.70%
  9. Oesophageal Mass: 2 people, 8.70%
  10. Oesophageal Stenosis (narrowing of oesophagus): 2 people, 8.70%

Common conditions people have *:

  1. Bone Density Decreased: 4 people, 17.39%
  2. Quit Smoking: 2 people, 8.70%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.35%
  4. Renal Cell Carcinoma (a kidney cancer): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Oesophageal carcinoma?

Check whether Oesophageal carcinoma is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Oesophageal carcinoma and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Alternative drugs to, pros and cons of Actonel:

Common Actonel side effects:

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Oesophageal carcinoma treatments and more:

COVID vaccines that are related to Oesophageal carcinoma:

Common drugs associated with Oesophageal carcinoma:

All the drugs that are associated with Oesophageal carcinoma:

Common conditions associated with Oesophageal carcinoma:

All the conditions that are associated with Oesophageal carcinoma:

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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