Actonel and Z-e syndrome - a phase IV clinical study of FDA data


Z-e syndrome is reported only by a few people who take Actonel.

The phase IV clinical study analyzes which people take Actonel and have Z-e syndrome. It is created by eHealthMe based on reports of 28,020 people who have side effects while taking Actonel from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jan, 13, 2023

28,020 people reported to have side effects when taking Actonel.
Among them, 2 people (0.01%) have Z-e syndrome.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 28,457 Actonel users for its effectiveness, alternative drugs and more.

What is Z-e syndrome?

Z-e syndrome (increased production of the hormone gastrin from a small tumour of pancreas) is found to be associated with 153 drugs and 167 conditions by eHealthMe.

Number of Actonel and Z-e syndrome reports submitted per year:

Could Actonel cause Z-e syndrome?

Gender of people who have Z-e syndrome when taking Actonel *:

  • female: 0.0 %
  • male: 100 %

Age of people who have Z-e syndrome when taking Actonel *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 100 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Actonel *:

  1. Crestor: 2 people, 100.00%
  2. Amaryl: 2 people, 100.00%
  3. Rabeprazole Sodium: 1 person, 50.00%

Common side effects people have besides Z-e syndrome *:

  1. The Flu (the flu is caused by an influenza virus): 2 people, 100.00%
  2. Purulence (containing pus): 2 people, 100.00%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 100.00%
  4. Diarrhea: 2 people, 100.00%
  5. Blood Gastrin Increased: 2 people, 100.00%
  6. Neoplasm Malignant (cancer tumour): 1 person, 50.00%
  7. Malignant Neoplasm Progression (cancer tumour came back): 1 person, 50.00%

Common conditions people have *:

  1. Taste - Impaired: 2 people, 100.00%
  2. Pancreatic Neuroendocrine Tumor: 2 people, 100.00%
  3. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 100.00%
  4. Hyperglycemia (high blood sugar): 2 people, 100.00%
  5. Hypercalcaemia (elevated calcium (ca+) level in the blood): 2 people, 100.00%
  6. Gastritis (inflammation of stomach): 2 people, 100.00%
  7. Diarrhea: 2 people, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Actonel and have Z-e syndrome?

Check whether Z-e syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Z-e syndrome and when was it recovered:

Expand to all the drugs that have ingredients of risedronate sodium:

Alternative drugs to, pros and cons of Actonel:

Common Actonel side effects:

Browse all side effects of Actonel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Z-e syndrome treatments and more:

COVID vaccines that are related to Z-e syndrome:

All the drugs that are associated with Z-e syndrome:

All the conditions that are associated with Z-e syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on risedronate sodium (the active ingredients of Actonel) and Actonel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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