Actos and Dupuytren's contracture - a phase IV clinical study of FDA data

Summary:

Dupuytren's contracture is reported only by a few people who take Actos.

The phase IV clinical study analyzes which people take Actos and have Dupuytren's contracture. It is created by eHealthMe based on reports of 48,025 people who have side effects while taking Actos from the FDA, and is updated regularly.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jun, 30, 2022

48,025 people reported to have side effects when taking Actos.
Among them, 3 people (0.01%) have Dupuytren's contracture.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 48,680 Actos users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 435 drugs and 194 conditions by eHealthMe.

Number of Actos and Dupuytren's contracture reports submitted per year:

Could Actos cause Dupuytren's contracture?

Gender of people who have Dupuytren's contracture when taking Actos *:

female: 66.67 %
male: 33.33 %

Age of people who have Dupuytren's contracture when taking Actos *:

Common drugs people take besides Actos *:

Fish Oil: 2 people, 66.67%
Xiaflex: 1 person, 33.33%
Sertraline Hydrochloride: 1 person, 33.33%
Niaspan: 1 person, 33.33%
Magnesium: 1 person, 33.33%
Lisinopril: 1 person, 33.33%
Jalyn: 1 person, 33.33%
Humalog: 1 person, 33.33%
Cosopt: 1 person, 33.33%
Coq10: 1 person, 33.33%

Common side effects people have besides Dupuytren's contracture *:

Swelling: 1 person, 33.33%
Post Procedural Complication: 1 person, 33.33%
Arthropathy: 1 person, 33.33%
Blindness: 1 person, 33.33%
Blood Glucose Increased: 1 person, 33.33%
Chorioretinopathy (collection of fluid under the retina that results in visual distortion): 1 person, 33.33%
Cuts And Puncture Wounds: 1 person, 33.33%
Disability: 1 person, 33.33%
Drug Ineffective: 1 person, 33.33%
Ecchymosis (a discoloration of the skin resulting from bleeding underneath): 1 person, 33.33%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Actos:

Actos (48,680 reports)

Dupuytren's contracture treatments and more:

Dupuytren's contracture (2,028 reports)

COVID vaccines that are related to Dupuytren's contracture:

How severe was Dupuytren's contracture and when was it recovered:

Dupuytren's contracture in Actos

Expand to all the drugs that have ingredients of pioglitazone hydrochloride:

Dupuytren's contracture and drugs with ingredients of pioglitazone hydrochloride

Common drugs associated with Dupuytren's contracture:

Xiaflex: 137 reports

All the drugs that are associated with Dupuytren's contracture:

Dupuytren's contracture (435 drugs)

All the conditions that are associated with Dupuytren's contracture:

Dupuytren's contracture (194 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.