Actos and Ischaemic stroke - a phase IV clinical study of FDA data


Ischaemic stroke is found among people who take Actos, especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Actos and have Ischaemic stroke. It is created by eHealthMe based on reports of 48,451 people who have side effects when taking Actos from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

48,451 people reported to have side effects when taking Actos.
Among them, 41 people (0.08%) have Ischaemic stroke.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,109 Actos users for its effectiveness, alternative drugs and more.

What is Ischaemic stroke?

Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain) is found to be associated with 1,452 drugs and 995 conditions by eHealthMe.

Number of Actos and Ischaemic stroke reports submitted per year:

Could Actos cause Ischaemic stroke?

Time on Actos when people have Ischaemic stroke *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Ischaemic stroke when taking Actos *:

  • female: 41.46 %
  • male: 58.54 %

Age of people who have Ischaemic stroke when taking Actos *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 2.86 %
  • 50-59: 37.14 %
  • 60+: 60.0 %

Common drugs people take besides Actos *:

  1. Plavix: 15 people, 36.59%
  2. Vioxx: 13 people, 31.71%
  3. Lisinopril: 12 people, 29.27%
  4. Humalog: 11 people, 26.83%
  5. Aspirin: 9 people, 21.95%
  6. Crestor: 8 people, 19.51%
  7. Ambien: 8 people, 19.51%
  8. Niaspan: 7 people, 17.07%
  9. Miralax: 7 people, 17.07%
  10. Zetia: 7 people, 17.07%

Common side effects people have besides Ischaemic stroke *:

  1. Confusional State: 7 people, 17.07%
  2. Speech Impairment (Adult) (inability to speak (adult)): 7 people, 17.07%
  3. Memory Loss: 6 people, 14.63%
  4. High Blood Pressure: 6 people, 14.63%
  5. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 6 people, 14.63%
  6. Heart Attack: 6 people, 14.63%
  7. Stable Angina (a constant chest pain): 5 people, 12.20%
  8. Speech Disorder: 5 people, 12.20%
  9. Cardiac Failure Congestive: 5 people, 12.20%
  10. Cerebral Infarction (less blood supply to brain resulting tissue damage): 5 people, 12.20%

Common conditions people have *:

  1. High Blood Cholesterol: 7 people, 17.07%
  2. Osteoporosis (bones weak and more likely to break): 5 people, 12.20%
  3. High Blood Pressure: 4 people, 9.76%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.76%
  5. Psoriasis (immune-mediated disease that affects the skin): 4 people, 9.76%
  6. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 9.76%
  7. Depression: 3 people, 7.32%
  8. Hypersensitivity: 3 people, 7.32%
  9. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 7.32%
  10. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

Do you take Actos and have Ischaemic stroke?

Check whether Ischaemic stroke is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Ischaemic stroke and when was it recovered:

Expand to all the drugs that have ingredients of pioglitazone hydrochloride:

Alternative drugs to, pros and cons of Actos:

Common Actos side effects:

Browse all side effects of Actos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Ischaemic stroke treatments and more:

COVID vaccines that are related to Ischaemic stroke:

Common drugs associated with Ischaemic stroke:

All the drugs that are associated with Ischaemic stroke:

Common conditions associated with Ischaemic stroke:

All the conditions that are associated with Ischaemic stroke:

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Actos) and Actos (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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