Acyclovir and Joint crepitation - a phase IV clinical study of FDA data


Joint crepitation is found among people who take Acyclovir, especially for people who are male, 40-49 old.

The phase IV clinical study analyzes which people take Acyclovir and have Joint crepitation. It is created by eHealthMe based on reports of 33,006 people who have side effects when taking Acyclovir from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 06, 2022

33,006 people reported to have side effects when taking Acyclovir.
Among them, 7 people (0.02%) have Joint crepitation.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 34,450 Acyclovir users for its effectiveness, alternative drugs and more.

What is Joint crepitation?

Joint crepitation is found to be associated with 1,109 drugs and 693 conditions by eHealthMe.

Number of Acyclovir and Joint crepitation reports submitted per year:

Could Acyclovir cause Joint crepitation?

Gender of people who have Joint crepitation when taking Acyclovir *:

  • female: 14.29 %
  • male: 85.71 %

Age of people who have Joint crepitation when taking Acyclovir *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 33.33 %
  • 40-49: 66.67 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Acyclovir *:

  1. Levaquin: 6 people, 85.71%
  2. Ziagen: 5 people, 71.43%
  3. Didanosine: 5 people, 71.43%
  4. Kaletra: 5 people, 71.43%
  5. Prednisolone Acetate: 5 people, 71.43%
  6. Ms Contin: 5 people, 71.43%
  7. Neurontin: 5 people, 71.43%
  8. Guaifenesin: 1 person, 14.29%
  9. Flagyl: 1 person, 14.29%
  10. Flovent: 1 person, 14.29%

Common side effects people have besides Joint crepitation *:

  1. Weakness: 6 people, 85.71%
  2. Pain In Extremity: 6 people, 85.71%
  3. Fever: 6 people, 85.71%
  4. Hepatomegaly (abnormal enlargement of the liver): 5 people, 71.43%
  5. Gallbladder Enlargement: 5 people, 71.43%
  6. Pain Of Skin: 5 people, 71.43%
  7. Skin Discoloration: 5 people, 71.43%
  8. Fluid Intake Reduced: 5 people, 71.43%
  9. Joint Injury: 5 people, 71.43%
  10. Burning Sensation: 5 people, 71.43%

Common conditions people have *:

  1. Sinusitis (inflammation of sinus): 5 people, 71.43%
  2. Pain: 5 people, 71.43%
  3. Neuropathy Peripheral (surface nerve damage): 5 people, 71.43%
  4. Hiv Infection: 5 people, 71.43%
  5. Fever: 5 people, 71.43%
  6. Infection: 2 people, 28.57%
  7. Cough: 2 people, 28.57%
  8. Nausea (feeling of having an urge to vomit): 1 person, 14.29%
  9. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Acyclovir and have Joint crepitation?

Check whether Joint crepitation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Joint crepitation and when was it recovered:

Expand to all the drugs that have ingredients of acyclovir:

Alternative drugs to, pros and cons of Acyclovir:

Common Acyclovir side effects:

Browse all side effects of Acyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Joint crepitation treatments and more:

COVID vaccines that are related to Joint crepitation:

Common drugs associated with Joint crepitation:

All the drugs that are associated with Joint crepitation:

Common conditions associated with Joint crepitation:

All the conditions that are associated with Joint crepitation:

How the study uses the data?

The study uses data from the FDA. It is based on acyclovir (the active ingredients of Acyclovir) and Acyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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