Adcal and Raynaud's phenomenon - a phase IV clinical study of FDA data


Raynaud's phenomenon is reported only by a few people who take Adcal.

The phase IV clinical study analyzes which people take Adcal and have Raynaud's phenomenon. It is created by eHealthMe based on reports of 4,488 people who have side effects while taking Adcal from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 18, 2023

4,488 people reported to have side effects when taking Adcal.
Among them, 2 people (0.04%) have Raynaud's phenomenon.

What is Adcal?

Adcal has active ingredients of calcium carbonate. eHealthMe is studying from 4,524 Adcal users for its effectiveness, alternative drugs and more.

What is Raynaud's phenomenon?

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) is found to be associated with 1,448 drugs and 909 conditions by eHealthMe.

Number of Adcal and Raynaud's phenomenon reports submitted per year:

Could Adcal cause Raynaud's phenomenon?

Gender of people who have Raynaud's phenomenon when taking Adcal *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Raynaud's phenomenon when taking Adcal *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Adcal *:

  1. Paracetamol: 2 people, 100.00%
  2. Humira: 2 people, 100.00%
  3. Amlodipine: 2 people, 100.00%

Common side effects people have besides Raynaud's phenomenon *:

  1. Microangiopathy (disease of the capillaries (very small blood vessels), in which the capillary walls become so thick and weak that they bleed, leak protein): 2 people, 100.00%
  2. Left Ventricular Failure (left ventricle fails to contract forcefully): 2 people, 100.00%
  3. Injury: 2 people, 100.00%
  4. Viral Infection: 1 person, 50.00%
  5. Urinary Tract Infection: 1 person, 50.00%
  6. Oedema Peripheral (superficial swelling): 1 person, 50.00%
  7. Neck Pain: 1 person, 50.00%
  8. Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1 person, 50.00%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Adcal and have Raynaud's phenomenon?

Check whether Raynaud's phenomenon is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Raynaud's phenomenon and when was it recovered:

Expand to all the drugs that have ingredients of calcium carbonate:

Alternative drugs to, pros and cons of Adcal:

Common Adcal side effects:

Browse all side effects of Adcal:

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Raynaud's phenomenon treatments and more:

COVID vaccines that are related to Raynaud's phenomenon:

Common drugs associated with Raynaud's phenomenon:

All the drugs that are associated with Raynaud's phenomenon:

Common conditions associated with Raynaud's phenomenon:

All the conditions that are associated with Raynaud's phenomenon:

How the study uses the data?

The study uses data from the FDA. It is based on calcium carbonate (the active ingredients of Adcal) and Adcal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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