Adderall and Parkinson's disease - a phase IV clinical study of FDA data

Summary:

We study 47,350 people who have side effects when taking Adderall. Parkinson's disease is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 2 years, also take Xyrem and have Cataplexy.

The phase IV clinical study analyzes which people take Adderall and have Parkinson's disease. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

47,350 people reported to have side effects when taking Adderall.
Among them, 41 people (0.09%) have Parkinson's disease.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is used in attention deficit hyperactivity disorder. Currently, eHealthMe is studying from 60,821 Adderall users.

What is Parkinson's disease?

Parkinson's disease is found to be associated with 2,053 drugs and 1,546 conditions by eHealthMe. Currently, we are studying 140,936 people who have Parkinson's disease.

Number of Adderall and Parkinson's disease reports submitted per year:

Could Adderall cause Parkinson's disease?

Time on Adderall when people have Parkinson's disease *:

Gender of people who have Parkinson's disease when taking Adderall *:

female: 60.98 %
male: 39.02 %

Age of people who have Parkinson's disease when taking Adderall *:

Common drugs people take besides Adderall *:

Common side effects people have besides Parkinson's disease *:

Fatigue (feeling of tiredness): 12 people, 29.27%
Movement - Uncontrolled Or Slow: 8 people, 19.51%
Tremor (trembling or shaking movements in one or more parts of your body): 8 people, 19.51%
Muscle Aches (muscle pain): 7 people, 17.07%
High Blood Pressure: 7 people, 17.07%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 6 people, 14.63%
Disability: 6 people, 14.63%
Stress And Anxiety: 6 people, 14.63%
Tardive Dyskinesia (a disorder that involves involuntary movements): 6 people, 14.63%
Catatonia (unresponsive to external stimuli): 5 people, 12.20%

Common conditions people have *:

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 21.95%
Drowsiness: 5 people, 12.20%
Back Pain: 4 people, 9.76%
Tardive Dyskinesia (a disorder that involves involuntary movements): 3 people, 7.32%
Belching (release of gas from the digestive tract): 3 people, 7.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 4.88%
Sleep Disorder: 2 people, 4.88%
Post-Traumatic Stress Disorder: 2 people, 4.88%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 4.88%
Type 2 Diabetes: 1 person, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Adderall and have Parkinson's disease?

Check whether Parkinson's disease is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Woulfe JM, Gray MT, Gray DA, Munoz DG, Middeldorp JM, "Hypothesis: a role for EBV-induced molecular mimicry in Parkinson's disease", Parkinsonism & related disorders, 2014 Jul .

Related studies

Adderall side effects by duration, gender and age:

Adderall side effects (60,821 reports)

Parkinson's disease treatments and more:

Parkinson's disease (140,936 reports)

Common drugs associated with Parkinson's disease:

All the drugs that are associated with Parkinson's disease:

Parkinson's disease (2,053 drugs)

Common conditions associated with Parkinson's disease:

Depression: 1,536 reports
High blood pressure: 1,074 reports
Schizophrenia: 904 reports
Hallucinations: 789 reports

All the conditions that are associated with Parkinson's disease:

Parkinson's disease (1,546 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Adderall) and Adderall (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.