Advil cold and sinus and Cough aggravated - a phase IV clinical study of FDA data


We study 1,364 people who have side effects when taking Advil cold and sinus. Cough aggravated is found, especially among people who are female, 60+ old, have been taking the drug for < 1 month, also take Claritin and have Nasopharyngitis.

The phase IV clinical study analyzes which people take Advil cold and sinus and have Cough aggravated. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2023

1,364 people reported to have side effects when taking Advil cold and sinus.
Among them, 20 people (1.47%) have Cough aggravated.

What is Advil cold and sinus?

Advil cold and sinus has active ingredients of ibuprofen; pseudoephedrine hydrochloride. It is used in sinus headache. Currently, eHealthMe is studying from 1,637 Advil cold and sinus users.

What is Cough aggravated?

Cough aggravated (worse cough) is found to be associated with 2,221 drugs and 816 conditions by eHealthMe. Currently, we are studying 279 people who have Cough aggravated.

Number of Advil cold and sinus and Cough aggravated reports submitted per year:

Could Advil cold and sinus cause Cough aggravated?

Time on Advil cold and sinus when people have Cough aggravated *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Cough aggravated when taking Advil cold and sinus *:

  • female: 63.16 %
  • male: 36.84 %

Age of people who have Cough aggravated when taking Advil cold and sinus *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 23.08 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 23.08 %
  • 60+: 53.85 %

Common drugs people take besides Advil cold and sinus *:

  1. Mucinex: 2 people, 10.00%
  2. Celebrex: 2 people, 10.00%
  3. Fentanyl: 2 people, 10.00%
  4. M.v.i.: 2 people, 10.00%
  5. Enbrel: 2 people, 10.00%
  6. Emend: 2 people, 10.00%
  7. Zantac: 2 people, 10.00%
  8. Nasonex: 2 people, 10.00%
  9. Compazine: 2 people, 10.00%
  10. Claritin: 2 people, 10.00%

Common side effects people have besides Cough aggravated *:

  1. Headache (pain in head): 6 people, 30.00%
  2. Rhinorrhea (watery mucus discharge from the nose): 4 people, 20.00%
  3. Breathing Difficulty: 4 people, 20.00%
  4. Diarrhea: 4 people, 20.00%
  5. Malaise (a feeling of general discomfort or uneasiness): 4 people, 20.00%
  6. Nausea (feeling of having an urge to vomit): 4 people, 20.00%
  7. Drug Ineffective: 4 people, 20.00%
  8. Feeling Abnormal: 4 people, 20.00%
  9. Face Oedema (swelling of face): 3 people, 15.00%
  10. Joint Pain: 3 people, 15.00%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 15.00%
  2. Nasopharyngitis (inflammation of the nasopharynx): 3 people, 15.00%
  3. Tuberculin Test Positive: 2 people, 10.00%
  4. Paranasal Sinus Hypersecretion: 2 people, 10.00%
  5. Headache (pain in head): 1 person, 5.00%
  6. Breathing Difficulty: 1 person, 5.00%
  7. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 5.00%
  8. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.00%
  9. Dry Eyes (lack of adequate tears): 1 person, 5.00%
  10. General Symptom: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Advil cold and sinus and have Cough aggravated?

Check whether Cough aggravated is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Advil cold and sinus side effects by duration, gender and age:

Cough aggravated treatments and more:

Common drugs associated with Cough aggravated:

All the drugs that are associated with Cough aggravated:

Common conditions associated with Cough aggravated:

All the conditions that are associated with Cough aggravated:

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen; pseudoephedrine hydrochloride (the active ingredients of Advil cold and sinus) and Advil cold and sinus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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