Alendronate sodium and Dupuytren's contracture - a phase IV clinical study of FDA data


Dupuytren's contracture is found among people who take Alendronate sodium, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Alendronate sodium and have Dupuytren's contracture. It is created by eHealthMe based on reports of 32,541 people who have side effects when taking Alendronate sodium from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trials. Phase IV trials are used to detect adverse drug outcomes and monitor effectiveness after drugs are approved to the market. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jun, 29, 2022

32,541 people reported to have side effects when taking Alendronate sodium.
Among them, 25 people (0.08%) have Dupuytren's contracture.

What is Alendronate sodium?

Alendronate sodium has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 33,167 Alendronate sodium users for its effectiveness, alternative drugs and more.

What is Dupuytren's contracture?

Dupuytren's contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers) is found to be associated with 443 drugs and 205 conditions by eHealthMe.

Number of Alendronate sodium and Dupuytren's contracture reports submitted per year:

Could Alendronate sodium cause Dupuytren's contracture?

Time on Alendronate sodium when people have Dupuytren's contracture *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 8.33 %
  • 6 - 12 months: 8.33 %
  • 1 - 2 years: 33.33 %
  • 2 - 5 years: 41.67 %
  • 5 - 10 years: 8.33 %
  • 10+ years: 0.0 %

Gender of people who have Dupuytren's contracture when taking Alendronate sodium *:

  • female: 87.5 %
  • male: 12.5 %

Age of people who have Dupuytren's contracture when taking Alendronate sodium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 33.33 %
  • 60+: 66.67 %

Common drugs people take besides Alendronate sodium *:

  1. Fosamax: 19 people, 76.00%
  2. Furosemide: 7 people, 28.00%
  3. Reclast: 4 people, 16.00%
  4. Enalapril Maleate: 2 people, 8.00%
  5. Methotrexate: 2 people, 8.00%
  6. Prednisone: 2 people, 8.00%
  7. Neurontin: 2 people, 8.00%
  8. Zolpidem: 1 person, 4.00%
  9. Finasteride: 1 person, 4.00%
  10. Ergocalciferol: 1 person, 4.00%

Common side effects people have besides Dupuytren's contracture *:

  1. Fall: 18 people, 72.00%
  2. Intervertebral Disc Protrusion (spinal disc protrusion): 15 people, 60.00%
  3. Femur Fracture: 15 people, 60.00%
  4. Intervertebral Disc Degeneration (spinal disc degeneration): 15 people, 60.00%
  5. Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 13 people, 52.00%
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 13 people, 52.00%
  7. Anaemia (lack of blood): 13 people, 52.00%
  8. Back Pain: 12 people, 48.00%
  9. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 12 people, 48.00%
  10. Depression: 12 people, 48.00%

Common conditions people have *:

  1. Swelling: 5 people, 20.00%
  2. Polymyalgia Rheumatica (pain in many muscles): 4 people, 16.00%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.00%
  4. Neuropathic Pain (pain due to nerve inflammation and damage): 2 people, 8.00%
  5. Type 2 Diabetes: 1 person, 4.00%
  6. Prostate Cancer: 1 person, 4.00%
  7. Indigestion: 1 person, 4.00%
  8. High Blood Pressure: 1 person, 4.00%
  9. High Blood Cholesterol: 1 person, 4.00%
  10. Bone Density Decreased: 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Alendronate sodium and have Dupuytren's contracture?

Check whether Dupuytren's contracture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Dupuytren's contracture and when was it recovered:

Expand to all the drugs that have ingredients of alendronate sodium:

Alternative drugs to, pros and cons of Alendronate sodium:

Common Alendronate sodium side effects:

Browse all side effects of Alendronate sodium:

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Dupuytren's contracture treatments and more:

COVID vaccines that are related to Dupuytren's contracture:

Common drugs associated with Dupuytren's contracture:

All the drugs that are associated with Dupuytren's contracture:

All the conditions that are associated with Dupuytren's contracture:

How the study uses the data?

The study uses data from the FDA. It is based on alendronate sodium (the active ingredients of Alendronate sodium) and Alendronate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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