Alendronate sodium and Ear popping - a phase IV clinical study of FDA data


Ear popping is found among people who take Alendronate sodium, especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Alendronate sodium and have Ear popping. It is created by eHealthMe based on reports of 36,457 people who have side effects when taking Alendronate sodium from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Dec, 10, 2022

36,457 people reported to have side effects when taking Alendronate sodium.
Among them, 45 people (0.12%) have Ear popping.

What is Alendronate sodium?

Alendronate sodium has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 37,110 Alendronate sodium users for its effectiveness, alternative drugs and more.

What is Ear popping?

Ear popping is found to be associated with 928 drugs and 569 conditions by eHealthMe.

Number of Alendronate sodium and Ear popping reports submitted per year:

Could Alendronate sodium cause Ear popping?

Time on Alendronate sodium when people have Ear popping *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 62.5 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 25.0 %
  • 2 - 5 years: 12.5 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Ear popping when taking Alendronate sodium *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Ear popping when taking Alendronate sodium *:

  • 0-1: 2.78 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 2.78 %
  • 40-49: 30.56 %
  • 50-59: 33.33 %
  • 60+: 30.56 %

Common drugs people take besides Alendronate sodium *:

  1. Fosamax: 45 people, 100.00%
  2. Seroquel: 9 people, 20.00%
  3. Lexapro: 9 people, 20.00%
  4. Prednisone: 9 people, 20.00%
  5. Celebrex: 8 people, 17.78%
  6. Vitamins: 7 people, 15.56%
  7. Enbrel: 7 people, 15.56%
  8. Actonel: 5 people, 11.11%
  9. Levoxyl: 4 people, 8.89%
  10. Celexa: 3 people, 6.67%

Common side effects people have besides Ear popping *:

  1. Femur Fracture: 25 people, 55.56%
  2. Impaired Healing: 24 people, 53.33%
  3. High Blood Cholesterol: 24 people, 53.33%
  4. Upper Respiratory Tract Infection: 23 people, 51.11%
  5. Sinusitis (inflammation of sinus): 23 people, 51.11%
  6. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 22 people, 48.89%
  7. Hyperlipidaemia (presence of excess lipids in the blood): 22 people, 48.89%
  8. Joint Pain: 21 people, 46.67%
  9. Cataract (clouding of the lens inside the eye): 20 people, 44.44%
  10. Osteonecrosis Of Jaw (death of bone of jaw): 19 people, 42.22%

Common conditions people have *:

  1. Bone Density Decreased: 10 people, 22.22%
  2. Psoriasis (immune-mediated disease that affects the skin): 10 people, 22.22%
  3. High Blood Cholesterol: 8 people, 17.78%
  4. Urticaria (rash of round, red welts on the skin that itch intensely): 7 people, 15.56%
  5. High Blood Pressure: 7 people, 15.56%
  6. Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 15.56%
  7. Inflammation: 7 people, 15.56%
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 11.11%
  9. Depression: 3 people, 6.67%
  10. Postmenopause: 2 people, 4.44%

* Approximation only. Some reports may have incomplete information.

Do you take Alendronate sodium and have Ear popping?

Check whether Ear popping is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Ear popping and when was it recovered:

Expand to all the drugs that have ingredients of alendronate sodium:

Alternative drugs to, pros and cons of Alendronate sodium:

Common Alendronate sodium side effects:

Browse all side effects of Alendronate sodium:

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Ear popping treatments and more:

COVID vaccines that are related to Ear popping:

Common drugs associated with Ear popping:

All the drugs that are associated with Ear popping:

Common conditions associated with Ear popping:

All the conditions that are associated with Ear popping:

How the study uses the data?

The study uses data from the FDA. It is based on alendronate sodium (the active ingredients of Alendronate sodium) and Alendronate sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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